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- 저자 : Andrés García-Sánchez (검색결과 2 건)
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Role of TRPV4 Channel in Human White Adipocytes Metabolic Activity
Julio C. Sánchez,Aníbal Valencia-Vásquez,Andrés M. García 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.5
Background: Intracellular calcium (Ca2+) homeostasis plays an essential role in adipocyte metabolism and its alteration is associatedwith obesity and related disorders. Transient receptor potential vanilloid 4 (TRPV4) channels are an important Ca2+ pathway in adipocytes and their activity is regulated by metabolic mediators such as insulin. In this study, we evaluated the role of TRPV4 channelsin metabolic activity and adipokine secretion in human white adipocytes. Methods: Human white adipocytes were freshly cultured and the effects of the activation and inhibition of TRPV4 channels on lipolysis, glucose uptake, lactate production, and leptin and adiponectin secretion were evaluated. Results: Under basal and isoproterenol-stimulated conditions, TRPV4 activation by GSK1016709A decreased lipolysis whereasHC067047, an antagonist, increased lipolysis. The activation of TRPV4 resulted in increased glucose uptake and lactate productionunder both basal conditions and insulin-stimulated conditions; in contrast HC067047 decreased both parameters. Leptin productionwas increased, and adiponectin production was diminished by TRPV4 activation and its inhibition had the opposite effect. Conclusion: Our results suggested that TRPV4 channels are metabolic mediators involved in proadipogenic processes and glucosemetabolism in adipocyte biology. TRPV4 channels could be a potential pharmacological target to treat metabolic disorders.
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Marycruz Barocio-Pantoja,Patricia Quezada-Fernández,David Cardona-Muller,Mayra B Jiménez-Cázarez,Mariana Larios-Cárdenas,Oscar I. González-Radillo,Andrés García-Sánchez,Jaime Carmona-Huerta,Ana N. Chá 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.12
One of the proposed mechanisms for the development of diabetic nephropathy (DN) is the increase of end products of advanced glycosylation (AGEs), which bind to its receptor (RAGE), favoring nephron cellular damage. An isoform of this receptor is soluble RAGE (sRAGE), which can antagonize AGE-altered intracellular signaling. It has known that green tea extract (GTE) increases the expression of sRAGE, but it is unknown whether this could improve kidney function. The objective of this study was to evaluate the effect of the administration of GTE on the concentrations of sRAGE, renal function, and metabolic profile in patients with type 2 diabetes mellitus (T2DM) and DN. A randomized, double-blinded, placebo-controlled clinical trial was carried out in 39 patients who received GTE (400 mg every 12 h) or placebo for 3 months. sRAGE levels, renal function, and metabolic parameters were determined before and after the intervention. In the GTE group, there were statistically significant increase on sRAGE (320.55 ± 157.63 pg/mL vs. 357.59 ± 144.99 pg/mL; P = .04) and glomerular filtration rate (GFR; 66.44 ± 15.17 mL/min/1.73 m2 vs. 71.70 ± 19.33 mL/min/1.73 m2; P = .04), and a statistically significant decrease in fasting serum glucose (7.62 ± 3.00 mmol/L vs. 5.86 ± 1.36 mmol/L; P ≤ .01) and triacylglycerols (1.91 ± 0.76 mmol/L vs. 1.58 ± 0.69; P = .02). Administration of GTE increases the serum concentration of sRAGE and the GFR and decreases the concentration of fasting serum glucose and triacylglycerols. The study was registered in ClinicalTrials.gov with the identifier NCT03622762.
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