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RISS 인기검색어
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- 저자 : An Dingjie (검색결과 4 건)
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Bin Cheng,Dingjie Guan,Bingxue Jing 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.2
Small and medium-sized manufacturing enterprises involve a lot of customized products. The degree of adaptability should be noted while improving product design and manufacturing digital and intelligent levels. This paper presents a process sequencing method of manufacturing features based on the node importance of a complex network. The method is based on the adjacency matrix and connected graph to analyze the process constraint semantics of the product model. The adjacency matrix expresses the positioning dimensions between features. The connected graph is applied to define the constraint relationships between features and aggregate the multi-dimensional process dimension chain in all directions. Based on the processing sequence of node importance in a complex network, most of process planning can be realized. The method also can make adaptive decisions for different structural parts and monitor the machining of key features. Examples verify the validity and feasibility of the proposed method.
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Guan Yongchao,Zhang Meng,Wang Yingda,Liu Zhongzhuo,Zhao Zelin,Wang Hong,An Dingjie,Qian Aidong,Kang Yuanhuan,Sun Wuwen,Shan Xiaofeng 한국미생물학회 2022 The journal of microbiology Vol.60 No.12
Aeromonas veronii is a pathogen which can induce diseases in humans, animals and aquatic organisms, but its pathogenic mechanism and virulence factors are still elusive. In this study, we successfully constructed a mutant strain (ΔascP) by homologous recombination. The results showed that the deletion of the ascP gene significantly down-regulated the expression of associated effector proteins in A. veronii compared to its wild type. The adhesive and invasive abilities of ΔascP to EPC cells were 0.82-fold lower in contrast to the wild strain. The toxicity of ΔascP to cells was decreased by about 2.91-fold (1 h) and 1.74-fold (2 h). Furthermore, the LD50 of the mutant strain of crucian carp was reduced by 19.94-fold, and the virulence was considerably attenuated. In contrast to the wild strain, the ΔascP content in the liver and spleen was considerably lower. The titers of serum cytokines (IL-8, TNF-α, and IL-1β) in crucian carp after the infection of the ΔascP strain were considerably lower in contrast to the wild strain. Hence, the ascP gene is essential for the etiopathogenesis of A. veronii TH0426.
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Overexpression of Platelet-derived Growth Factor-D as a Poor Prognosticator in Endometrial Cancer
Ding, Jie,Li, Xiao-Mao,Liu, Sui-Ling,Zhang, Yu,Li, Tian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: Emerging evidence implicates the platelet-derived growth factor-D (PDGF-D) in many types of human solid tumors. We investigated whether PDGF-D plays an important role in endometrial cancer (EC) in relation to clinicopathologic phenotype, angiogenesis, and patient prognosis. Materials and Methods: We analyzed PDGF-D protein expression by Western blotting in twenty-seven human endometrial cancer tissues, and matched normal endometrial controls collected at the third Affiliated hospital of Sun Yat-sen University during 2012-2013 (n=27). Immunohistochemical staining was performed using a human PDGF-D antibody on the endometrial cancer patients collected in the same facility during January 2001 and October 2013 (n=152). Patients were followed from the time of primary surgery in 2001-2013 until death or last follow-up. We correlated the PDGF-D expression levels with clinicopathologic parameters and prognosis in human endometrial cancer patients. Results: Compared with matched normal endometrial cases, PDGF-D was up-regulated in endometrial cancer. Expression of PDGF-D protein, found in 78% of the cases, was associated with nonendometrioid histologic type (p=0.028), FIGO stage III/IV (p=0.039), >50% solid tumor growth (p=0.048), pelvic LN metastasis (p=0.035) and ER and PR negativity (p=0.04 and 0.002). PDGF-D expression was also significantly associated with expression of VEGF-A (p=0.021). In multivariate analysis, PDGF-D expression proved to be an independent prognostic factor in addition to histologic grade and FIGO stage. Patients with high expression levels of PDGF-D had a significantly poorer overall survival rate compared with patients with no expression. Conclusions: PDGF-D expression is frequently up-regulated in endometrial cancer, and is associated with aggressive features and poor prognosis.
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VALUE DISTRIBUTION OF DIFFERENCE OPERATOR ON MEROMORPHIC FUNCTIONS
Ding, Jie,Yang, Lian-Zhong Korean Mathematical Society 2014 대한수학회보 Vol.51 No.5
In this paper, we investigate the value distribution of the difference operator on meromorphic functions, and obtain a difference analogue of a theorem of Hayman on meromorphic functions.
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