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- 저자 : Aminu Musa (검색결과 3 건)
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Aminu Musa,Idris Maje,Chindo Ben,Mubarak Hussaini Ahmad 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.3
The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose (LD50) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic efects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed favonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral LD50 was above 5,000 mg/kg in mice. The EETG efectively (P<0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it signifcantly (P<0.05, P<0.01 and P<0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efciently (P<0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive efect elicited by the EETG in the formalinproduced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways.
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A bivariate statistical analysis for coal exploration within parts of the Anambra Basin in Nigeria
Adamu L. Musa,Andongma W. Tende,Jiriko N. Gajere,Mazadu D. Bako,Fatima Shinkafi,Mohammed D. Aminu 대한공간정보학회 2022 Spatial Information Research Vol.30 No.3
The Anambra Basin is rich in coal, and can be investigated regionally using predictive models developed with Geographic Information System (GIS). Several spatial and statistical approaches were employed in this study to determine the most prospective location for coal deposits, with a focus on accuracy and reliability. The relationship between coal occurrence and evidential data was assessed using the prediction area plot analysis, and coal predictive maps were developed using bivariate statistical models such as the Evidential Belief function (EBF), Statistical Index (SI), and Frequency Ratio (FR) models. The accuracy of all predictive models was assessed using the Receiver Operating/Area Under Curve (ROC/AUC) analysis. The application of prediction area plot analysis suggests a substantial correlation can be established between coal resources and spatial data on geology (0.75) and lineament density (0.74). Based on spatial data integration using bivariate models, the north-central and south-central parts of the study area have a high potential for coal occurrence. Comparatively, the very high potential class accounts for 5.3%, 3.64%, 7.14%, and 2.04%, respectively, in the EBF, Uncertainty, SI and FR models. Statistical validation using the ROC/AUC analysis demonstrated prediction accuracies of 83%, 79%, 78%, and 82%, respectively, for the belief, uncertainty, SI, and FR models. In general, GIS predictive modelling for coal resource exploration is strongly recommended in the Anambra Basin and other sedimentary basins with similar geological settings.
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Usman Abdulrasheed,Balogun Olayemi,Shuaib Bukhari Isah,Musa Bolanle O. P.,Yusuf Aminu Abba,Ajayi Ebenezer I. O. 대한감염학회 2023 Infection and Chemotherapy Vol.55 No.4
Background: Cytopenias serve as common indicators and crucial predictive tools for evaluating disease progression and therapeutic outcomes in individuals with human immunodeficiency virus (HIV) infection. This study aimed to assess the prevalence of cytopenias and their correlation with the level of immunosuppression in treatment-naive HIV-infected participants after initiating highly active combined antiretroviral drug therapy (cART24). Materials and Methods: This prospective study focused on evaluating cytopenia in 44 treatment-naive HIVinfected patients who consented to initiate cART and were consecutively enrolled. The research was conducted at the Nasara HIV Treatment & Care Centre of Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria, spanning from December 2016 to January 2018. Cytopenias, including anemia, leucopenia, lymphocytopenia, and thrombocytopenia, were defined and assessed according to World Health Organization guidelines. A combination of cross-sectional and longitudinal mixed-design two-step analysis was employed to validate our findings. Results: The median time from enrollment to cART initiation was 7 days, following the universal test and treat protocol. The prevalence of cytopenia was 75% at the baseline before treatment and increased to 84% after cART24 administration. There were no statistically significant differences in the median values of immuno-hematological parameters between baseline and after cART24 initiation (P >0.05). In terms of longitudinal assessment, the prevalence of anemia, leucopenia, lymphopenia, and thrombocytopenia at baseline were 66%, 23%, 0%, and 11%, respectively, and after cART24, the rates were 66%, 29%, 5%, and 20%. Notably, the prevalence of cytopenia correlated with declining CD4+ T cell counts. Among instances of unicytopenia, 58% exhibited isolated anemia, 6% had lone leucopenia, and 6% had solitary thrombocytopenia. Additionally, 27% demonstrated bi-cytopenia, and 3% exhibited pancytopenia. Interestingly, none of the study participants presented with lymphopenia. The most common combination was anemia and thrombocytopenia. Both longitudinal and cross-sectional analytical findings were consistent. Conclusion: In treatment-naive HIV-infected individuals, the prevalence of cytopenias, particularly anemia and thrombocytopenia, was substantial and correlated with the degree of immunosuppression as indicated by CD4+ T cell counts. These cytopenias persisted despite initiation of cART24, highlighting the complexity of hematological manifestations in HIV infection. Our study underscores the significant hematopathological impact of HIV and antiretroviral therapy, highlighting the necessity for preventive strategies to mitigate these adverse effects.
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