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Derakhshan Ali Reza,Saeidinejat Shahin,Khadem-Rezaiyan Majid,Asnaashari Amir-Mohammad-Hashem,Mirsadraee Majid,Salari Roshanak,Jabbari-Azad Farahzad,Jalali Shima,Jalali Shabnam 대한약침학회 2022 Journal of pharmacopuncture Vol.25 No.3
Objectives: Asthma is a chronic disease, and the demand for herbal medicines in this field has increased in recent years. The new findings highlight the role of the gut-lung axis in the pathophysiology of asthma. Hence, this study will evaluate the safety and efficacy of Glasthma syrup, an herbal formula based on Persian medicine, in improving asthma and regulating intestinal permeability. The formula consists of five herbal ingredients that have anti-inflammatory effects on the respiratory tract, also known as gut tonics. Methods: The study will be conducted as a placebo-controlled, triple-blind, randomized trial. It will consist of a 4-week intervention followed by a 4-week follow-up period. The target sample size is 20 patients with moderate asthma aged 18 to 60 years. Eligible participants will be randomly assigned to either the experimental group or the control group in equal numbers. Patients in the experimental group will take Glasthma syrup (7.5 mL, twice a day), while patients in the control group will take a matching placebo. Both groups will receive a 4-week combination of a long-acting beta2 agonist and a leukotriene modulator as standard of care. Inhaled corticosteroids can be used as rescue medication as needed. Results: The primary outcomes are asthma symptom scale, lung function, and intestinal permeability. Secondary outcomes include quality of life, symptom recurrence rates, and blood tests. A safety assessment will also be conducted during the trial. Conclusion: In this trial, the effects of Glasthma syrup in patients with moderate asthma will be examined. The study will also assess the effects of the formulation on the gut-lung axis by simultaneously monitoring the gut permeability index, asthma symptoms, and lung function.
Simulation of drop deformation and breakup in simple shear flow
Derakhshan Saeed,Kamyabi Ata Allah,Mohebbi Ali 한국유변학회 2024 Korea-Australia rheology journal Vol.36 No.2
The behavior of drops in the emulsion is significant in transport phenomena and the oil and the petrochemical industry. In this study, the behavior of drops that are close to each other was investigated. These drops were studied at two viscosity ratios (0.5 and 0.9, which are the viscosity ratio of drops to fluid) and six capillary numbers (0.05, 0.11, 0.17, 0.42, 0.28, and 0.36). The results demonstrate the effect of drops on each other at a range of volume fractions. Also, at capillary numbers of 0.42, 0.82, and 0.36, there were volume fractions at which drops stuck to each other and broke after combining. In contrast, the single drop at these new capillary numbers after merging was not broken. At the capillary number of 0.84, and volume fraction of 0.001495, the drops did not stick to each other, but they were broken under the influence of each other. For each capillary number, a specified volume fraction was achieved, at which the drops behave as a single drop. Therefore, in each capillary number, a volume fraction can be found so that in volume fractions less than that, drops behave individually and do not interact with each other.
Zahra Derakhshan,Mohammad Hassan Ehrampoush,Amir Hossein Mahvi,Mansooreh Dehghani,Mohammad Faramarzian,Mohammad Taghi Ghaneian,Mehdi Mokhtari,Ali Asghar Ebrahimi,Hossein Fallah Zadeh 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.67 No.-
The present study examined a moving bed biofilm reactor (MBBR) bioreactor on a laboratory scale for simultaneous removal of atrazine, organic carbon, and nutrients from wastewater. The maximum removal efficiency of atrazine, chemical oxygen demand (COD), total phosphorus (TP) and total nitrogen (TN) were 83.57%, 90.36%, 90.74% and 87.93 respectively. Increasing salinity up to 40 g/L NaCl in influent flow could inhibit atrazine biodegradation process strongly in the MBBR reactor.Results showed that MBBR is so suitable process for efficiently biodegrading of atrazine and nitrogen removal process was based on the simultaneous nitrification-denitrification (SND) process.
Farzaneh Mohammadzadeh Kazorgah,Azam Govahi,Ali Dadseresht,Fatemeh Nejat Pish Kenari,Marziyeh Ajdary,Rana Mehdizadeh,Roya Derakhshan,Mehdi Mehdizadeh The Korean Society for Reproductive Medicine 2024 Clinical and Experimental Reproductive Medicine Vol.51 No.1
Objective: This study evaluated the effects of temperature and storage time on the quality and DNA integrity of freeze-dried sperm from individuals with normozoospermia. Methods: Normal sperm samples from 15 men aged 24 to 40 years were studied. Each sample was divided into six groups: fresh, freezing (frozen in liquid nitrogen), freeze-dried then preserved at room temperature for 1 month (FD-1m-RT), freeze-dried then preserved at room temperature for 2 months (FD-2m-RT), freeze-dried then preserved at 4 ℃ for 1 month (FD-1m-4 ℃), and freeze-dried then preserved at 4 ℃ for 2 months (FD-2m-4 ℃). The morphology, progressive motility, vitality, and DNA integrity of the sperm were evaluated in all groups. Results: In all freeze-dried groups, sperm cells were immotile after rehydration. The freeze-dried groups also showed significantly less sperm vitality than the fresh and frozen groups. Significantly more morphological sperm abnormalities were found in the freeze-dried groups, but freeze-drying did not lead to a significantly higher DNA fragmentation index (DFI). The DFI was significantly higher in the FD-2m-RT group than in the other freeze-dried groups. Conclusion: The freeze-drying method preserved the integrity of sperm DNA. The temperature and duration of storage were also identified as factors that influenced the DFI. Accordingly, more research is needed on ways to improve sperm quality in the freeze-drying process.
Safoora Rahimi,Rozita M. Moattari,Laleh Rajabi,Ali Ashraf Derakhshan,Mohammad Keyhan 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.23 No.-
Needle-like lepidocrocite nanoparticles with a diameter of 10–30 nm and a length of 100–300 nm and goethite nanospheres with a diameter of 10–60 nm were synthesized and examined as adsorbents for lead removal from solutions. FTIR, SEM and DLS characterized the nanomaterials. The most influential factor in the batch adsorption experiments by nanoparticles for capacity and removal efficiency was adsorbent dose and type of adsorbent, respectively. The optimum condition for lead removal by nanoparticles was found to be: C0 = 5 mg/L, pH = 5.2 and goethite as the more efficient adsorbent. Langmuir and Sips isotherms successfully described the adsorption of lead ions.
Hanieh Karimnezhad,Ehsan Salehi,Laleh Rajabi,Sara Azimi,Ali Ashraf Derakhshan,Meisam Ansari 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.6
Nanocomposite membranes were fabricated by dip-coating technique. Para-aminobenzoate alumoxane,boehmite–epoxide and chitosan were consecutively coated on the Kevlar fabric surface. The membraneswere utilized for removing n-hexane fromwater using a gravity-driven dead-end filtration setup. UV–vis,FTIR and SEM analyses were performed for characterization. Water affinity analyses revealed highlyhydrophilic nature of the modified membranes. Effect of pH was examined with the pH 2 providing thebest condition for oil–water separation. Maximum flux and rejection were obtained as 1128 Lm-2 h-1)and 94%, respectively. Deposited oil layer was effectively removed from the membrane surface using hotcitric acid solution.
Masood Aghakhani,Mohammad Reza Ghaderi,Maziar Mahdipour Jalilian,Ali Ashraf Derakhshan 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.7
Submerged arc welding (SAW) is a high-quality arc welding process used in heavy industries for welding thick plates. In this process,selecting appropriate values for the input parameters is required for high productivity and cost effectiveness. A very important weld quality characteristic affected by welding input parameters is the hardness of melted zone (HMZ). This paper reports the applicability of fuzzy logic (FL) to predict HMZ in the SAW process which is affected by the combined effect of TiO2 nano-particles and welding input parameters. The arc voltage, welding current, welding speed, contact tip-to-plate distance, and TiO2 nano-particles were used as input parameters and HMZ as the response to develop FL model. A five-level five-factor central composite rotatable design (CCRD) was used in the experiments to generate experimental data. Experiments were performed, and HMZs were measured. The predicted results from FL were compared with the experimental data. The correlation factor value obtained was 99.99% between the measured and predicted values of HMZ. The results showed that FL is an accurate and reliable technique for predicting HMZ because of its low error rate.