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RISS 인기검색어
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- 저자 : Alexander Strom (검색결과 2 건)
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Alexander Strom,Kirti Kaul,Jutta Brüggemann,Iris Ziegler,Ilka Rokitta,Sonja Püttgen,Julia Szendroedi,Karsten Müssig,Michael Roden,Dan Ziegler,the GDS Group 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Increased oxidative stress is implicated in the pathogenesis of experimental diabetic neuropathy, but translational evidence in recent-onset diabetes is scarce. We aimed to determine whether markers of systemic oxidative stress are associated with diabetic sensorimotor polyneuropathy (DSPN) in recent-onset diabetes. In this cross-sectional study, we measured serum concentrations of extracellular superoxide dismutase (SOD3), thiobarbituric acid reactive substances (TBARS), and reduced glutathione (GSH) in 107 type 1 and 215 type 2 diabetes patients from the German Diabetes Study baseline cohort and 37 glucose-tolerant individuals (controls). DSPN was defined by electrophysiological and clinical criteria (Toronto Consensus, 2011). SOD3 and GSH concentrations were lower in individuals with type 1 and type 2 diabetes compared with concentrations in controls (Po0.0001). In contrast, the TBARS concentration was higher in participants with type 1 diabetes and type 2 diabetes compared with levels in controls (Po0.0001). In addition, the SOD3 concentration was higher in participants with type 1 diabetes compared to concentrations in those with type 2 diabetes (Po0.0001). A low SOD3 concentration was associated with DSPN in individuals with type 1 diabetes (β=− 0.306, P=0.002), type 2 diabetes (β=− 0.164, P=0.017), and in both groups combined (β=− 0.206, P=0.0003). Lower SOD3 concentrations were associated with decreased motor nerve conduction velocity (NCV) in men and, to a lesser degree, with reduced sensory NCV in women with diabetes. In conclusion, several biomarkers of oxidative stress are altered in recent-onset diabetes, with only a lower SOD3 concentration being linked to the presence of DSPN, suggesting a role for reduced extracellular antioxidative defense against superoxide in the early development of DSPN
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키르기스스탄 Dead Lakes 암석 애벌런치의 운동 특성과 편년
오정식 ( Jeong-sik Oh ),성영배 ( Yeong Bae Seong ),알렉산더스트롬 ( Alexander Strom ),유병용 ( Byung Yong Yu ) 한국지리학회 2018 한국지리학회지 Vol.7 No.2
암석 애벌런치는 산사태의 다양한 유형 중에서도 가장 빠른 속도로 이동하며 규모가 큰 것으로 넓은 지역에 걸쳐 막대한 피해가 발생한다. 본 연구는 키르기스스탄 Dead Lakes에서 발생한 암석 애벌런치의 지형과 운동특성을 밝히고, 우주선유발 <sup>10</sup>Be을 이용하여 발생시기를 규명하였다. Dead Lakes 암석 애벌런치는 산정부 기반암의 붕괴로 시작되었으며, 이로부터 기인한 암설은 두부내벽 최상단(headscarp crown)으로부터 암설사면 말단까지 길이 7.5km, 비고차 1,750m에 걸쳐 이동했다. 암설 공급원의 규모는 평면상으로 폭 2.7km, 길이 2.5km 규모이다. 암설퇴적층의 두께는 평균 150m로 14.65㎢의 면적에 걸쳐 분포하며 추정된 부피는 약 2.2㎦이다. 4개의 구간에서 상이하게 진행된 고에너지 운동은 회전암체(toreva block), 암설능선(debris ridges), 제방(levees), 선구조(linear structures), 단구(terraces), 암설구릉(hummocks)과 같은 독특한 산사태 지형들을 바탕으로 구분된다. <sup>10</sup>Be 노출연대 측정을 통하여 밝혀진 Dead Lakes 암석 애벌런치의 발생시기는 48.3±2.4ka 무렵으로 확인되었으며, 단층 활동으로 인한 대규모 지진 발생이 발생원인으로 추정된다. Rock avalanches are one of the fastest type of landslides and because of their magnitude and energy, can cause huge damage over large areas. The purpose of this study is to demonstrate the characteristics of morphology and kinematics of Dead Lakes rock avalanche, Kyrgyzstan and to provide the timing of its occurrence constrained by cosmogenic <sup>10</sup>Be surface exposure dating. The Dead Lakes rock avalanche initiated with the collapse of the entire mountain slope up to its top, composed of bedrock, and moved for ca. 7.5 km with elevation decrease up to ~1750 m if measured from the headscarp crown to the deposit’s tip. Its source zone is up to 2.7 km by 2.5 km in plan view. The deposits thickness is about 150 m on the average and its volume is ~2.2 ㎦ over the area of 14.65 ㎢. Four different motion patterns evolved during high-energetic motion process can be revealed from the landslide-related landforms such as toreva block, debris ridges, levees, linear structures, terraces, and hummocks. The timing of occurrence of the Dead Lakes rock avalanche revealed by <sup>10</sup>Be exposure dating was 48.3±2.4 ka, which was likely to be triggered by huge earthquake.
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