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RISS 인기검색어
- 검색키워드
- 저자 : Al-Jumaily, Ahmed M. (검색결과 7 건)
- 무료
- 기관 내 무료
- 유료
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Combination of isoproterenol and length oscillations in relaxing porcine airway smooth muscles
Al-Jumaily, Ahmed M.,Mathur, Meha,Cairns, Simeon Techno-Press 2015 Biomaterials and biomedical engineering Vol.2 No.4
Treatments for asthma are largely pharmaceutical, with some therapies also utilising alternative breathing techniques. The objective of both medical and alternative methods is to relax contracted airway smooth muscle (ASM). In normal subjects, tidal breathing- and deep inspiration-oscillations are believed to have a bronchodilatory effect. Similarly, application of length oscillations to isolated, contracted ASM also elicits muscle relaxation. As a means of investigating more-effective alternative treatment methods for contracted airways, we analyse the combined effects of bronchodilators and length oscillations on isolated, contracted ASM. The contractile state of the muscle tissue prior to treatment is of primary interest. Thereafter, the effect of applying a combination of small superimposed length oscillations with tidal breathing-like oscillations to ASM is studied alone and in combination with a common bronchodilator, isoproterenol (ISO). This work suggests that relaxation of isolated, contracted ASM following application of combined oscillations and ISO is larger than treatments of either combined oscillations or ISO alone. Further, the observed oscillation-associated relaxation is found to be amplitude- rather than frequency-dependent. This study gives additional insight into the role of oscillations and bronchodilators on contracted airways.
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Combination of isoproterenol and length oscillations in relaxing porcine airway smooth muscles
Al-Jumaily, Ahmed M.,Mathur, Meha,Cairns, Simeon Techno-Press 2015 Biomaterials and Biomechanics in Bioengineering Vol.2 No.4
Treatments for asthma are largely pharmaceutical, with some therapies also utilising alternative breathing techniques. The objective of both medical and alternative methods is to relax contracted airway smooth muscle (ASM). In normal subjects, tidal breathing- and deep inspiration-oscillations are believed to have a bronchodilatory effect. Similarly, application of length oscillations to isolated, contracted ASM also elicits muscle relaxation. As a means of investigating more-effective alternative treatment methods for contracted airways, we analyse the combined effects of bronchodilators and length oscillations on isolated, contracted ASM. The contractile state of the muscle tissue prior to treatment is of primary interest. Thereafter, the effect of applying a combination of small superimposed length oscillations with tidal breathing-like oscillations to ASM is studied alone and in combination with a common bronchodilator, isoproterenol (ISO). This work suggests that relaxation of isolated, contracted ASM following application of combined oscillations and ISO is larger than treatments of either combined oscillations or ISO alone. Further, the observed oscillation-associated relaxation is found to be amplitude- rather than frequency-dependent. This study gives additional insight into the role of oscillations and bronchodilators on contracted airways.
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IDENTIFICATION OF AIRWAY CHARACTERISTICS USING THE INPUT IMPEDANCE
Ahmed M. Al-Jumaily,Seon Hwan Cheong 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
In an attempt to determine the correlations between the input acoustic impedance and the variations of the physical characteristics of the terminal elements, a five-lobe branched tubenetwork is mathematically developed and experimentally simulated using a lung simulator. The model takes into account some realistic conditions such as varying cross-sectional areas, flexible wall properties and branching. The effects of airway constrictions expressed by lobe stiffness variations on the impedance are determined for a range of frequencies up to 256 ㎐. It is concluded that the developed model is capable of non-invasively predicting various physiological changes in the airway passages.
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Miqdam M. Obaid AL-Jumaili 대한소화기학회 2024 대한소화기학회지 Vol.83 No.1
Background/Aims: Colorectal cancer is the most common cancer in oncopathology, with an increasing incidence among the elderly during the last decade. Various genetic and environmental factors play important roles in the emergence of colorectal adenocarcinoma. Non-coding RNAs, approximately 20–22 nucleotides, are transcribed irregularly in many cancer cells and play a critical role in many metabolic pathways in clinical cancer cases. DNA methylation is a critical epigenetic alteration that controls gene expression. In the current study, transcriptional silencing and CpG hypermethylation were developed as a therapeutic gene editing strategy for the clinical repression of colorectal adenocarcinoma. Methods: A human colorectal adenocarcinoma cell line (Caco2) and a normal lung fibroblast cell line (Wi38) were utilized as the paradigms in this research to examine the effect of mir155 molecule transfection and CpGs-island (CGI) methylation. Cell counting was achieved using six-well and 24-well plates before transfection using a hemocytometer. The two cell lines were transfected with the mir155 agomir and antagomir molecules. The transfection efficiency, cell viability, cell IC50, and target gene expression were measured, and CGIs-methylation was achieved by bisulfate conversion. Results: The outcomes revealed the downregulation of oncogenes (AKT1 and VCAM1 genes as cancer-associated genes) and the upregulation of tumor suppressor genes (TSGs, Tp53 and KEAP1). In addition, CpG-islands methylation showed significant blocking of the oncogene promoter regions, and the switch on of TSG promoter regions was continuous. Conclusions: miRNA-CGI-methylation led to the regression of Caco2 cell proliferation, suggesting the potential use of RNA silencing and DNA methylation in targeted gene therapy for colorectal cancer.
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Identification of airway characteristics using the input impedance
정선환,S. H. Ro,J. Y. Shon,A. M. Al-Jumaily 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.8
To understand how the input impedance determined at the throat correlates with changes in the dynamic characteristics of the airways, a simplified 5-lobe model is developed and simulated. The model takes into account some realistic conditions such as varying cross-sectional areas, flexible wall properties and branching. The lobe terminal impedances are implemented in the model to predict the input impedance at the throat. The effects of airway constrictions and wall elastance variations on this impedance are determined for a range of frequencies. It is concluded that the developed model is capable of predicting various physiological changes in the airway passages.
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