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Utsumi, Hideo,Akira Hamada 嶺南大學校 環境問題硏究所 1993 環境硏究 Vol.12 No.2
In order to establish the method of bio-assay for the safety of drinking water, genotoxicity and cytotoxicity of micropollutants in water were studied. Genotoxicity was estimated with Ames Salmonella mutagenicity test, and cytotoxicity was evaluated with the cultured mammalian cells, HL-60, rat liver hepatocytes and mouse peritoneal macrophages. The dissolved substances in water were recovered from raw, chlorinated, and rapid-filtrated waters by adsorption with XAD-2. Some of the samples showed strong direct genotoxicity and/or cytotoxicities, but no correlation was observed between the results with the two bio-assays. The findings indicate that the combination of genotoxicity test with cytotoxicity one is recommended to secure the safety of drinking water.