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- 검색키워드
- 저자 : Ajayi Abayomi Mayowa (검색결과 4 건)
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Ajayi Abayomi Mayowa,Alabi Akinyinka O.,Oyibo Alice O.,Joseph Olushola O. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.4
Phragmanthera incana (Schum) is a specie of mistletoe that has been mentioned in Nigeria ethnomedicine to be used in the treatment of inflammatory disorders. The aim of this study was to investigate the anti-inflammatory effect of Phragmanthera incana leaf ethanol extract (PIEE) in carrageenan-induced inflammation models in rats. In the carrageenan-induced rat paw oedema experiment, 0.1 mL of carrageenan (1%) was injected into the paw one hour after treatment with PIEE (125, 250 and 500 mg/kg). Paw volume was measured hourly for 4 h using the plethysmometer. The anti-inflammatory activity was investigated using the carrageenan-induced air pouch inflammation model. Leucocytes migration and pro-inflammatory mediators (TNF-α and IL-6) were evaluated in the air pouch exudate. Oxidative stress biomarkers (MDA, Nitrite, GSH and Catalase) were estimated in both the carrageenan-induced paw tissue homogenates and air pouch exudate. PIEE (125, 250 and 500 mg/kg) administration significantly (p < 0.05) reduced paw oedema hourly post-carrageenan injection. PIEE administration displayed dose-dependent significant (p < 0.05) reduction in fluid exudates and total leucocytes counts respectively. The extract administration also decreased elevated pro-inflammatory cytokines (TNF-α and IL-6) levels respectively. PIEE administration demonstrated antioxidant activity by attenuating carrageenan-induced increase in malondialdehyde and nitrite as well as decrease in reduced glutathione and catalase levels in rats. Phragmanthera incana leaf ethanol extract possess anti-inflammatory properties, suggesting protective function in inflammatory diseases.
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Ajayi Abayomi Mayowa,Ben-Azu Benneth,Sikiru O. Balogun,Ruberlei Godinho de Oliveira,Umukoro Solomon,Domingos Tabajara de Oliveira,Olusegun G. Ademowo 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.3
Ocimum gratissimum L. has attracted substantial consideration from researchers because of its anti-inflammatory uses in ethnomedicine in Sub-Saharan Africa and Asia. This study investigated the effect of flavonoid-rich ethylacetate fraction of O. gratissimum (EAFOg) in apoptosis induction of activated macrophages and inflammatory response in LPS-induced air pouch in rats. Apoptotic effect of EAFOg in LPS-stimulated RAW 264.7 cells was evaluated using flow cytometry after staining with annexin-V and 7-aminoactinomycin D. Its effects on inflammatory cells and mediators were investigated utilizing 6 day old subcutaneous air pouch-rats. Sterile saline (0.9%) or LPS (100 ng/mL) was injected into the air pouch on 6th day after EAFOg (25, 50 and 100 mg/kg) pretreatment. Rectal body temperature was recorded hourly for 5 h after LPS injection. Thereafter, the neutrophil count, nitrite, TNF-α, PGE2, nitrite, malondialdehyde and reduced glutathione (GSH) levels were determined in the pouch lavage. The activities of myeloperoxidase and superoxide dismutase (SOD) as well as immunohistochemical staining for cyclooxygenase-2 were also performed. EAFOg (10, 30 and 100 μg/mL) induced apoptosis in LPS-stimulated RAW 264.7 macrophages. The EAFOg reduced hyperthermia and decreased neutrophil counts, TNF-α, PGE2, nitrite, myeloperoxidase as well as cyclooxygenase-2 expression evoked by LPS in rats. It also reduced malondialdehyde, and increased GSH and SOD levels in LPS-induced air pouch in vivo. The results of this study suggest that the EAFOg
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Kabirat Temitope Babalola,Oyetola Oyebanjo,Victor Adetayo Adekoya,Ismaheel Akinwale Adeniyi,Abayomi Mayowa Ajayi,Samuel Adetunji Onasanwo 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.1
Cnidoscolus aconitifolius contains various phenolic compounds possessing anti-inflammatory and antioxidant properties. This study aimed to evaluate the protective effect of the Methanol Extract of Cnidoscolus aconitifolius (MECA) against LPS-induced memory impairment, oxidative stress and neuroinflammation in rats. Thirty male Wistar rats were divided into 5 groups (n = 6). Group 1 served as the control and received the vehicle, group 2 was negative control, groups 3–5 received MECA (25, 50, and 100 mg/kg) for 14 days. Groups 2–5 were daily injected with LPS (250 μg/kg, i.p) from day 8–14 of treatment. Memory impairment was evaluated after the last LPS administration using the Y-Maze Test (YMT) and Novel Object Recognition Test (NORT). Brain prefrontal cortex (PFC) and hippocampus (HPC) sections were obtained and levels of reduced glutathione (GSH), malondialdehyde, catalase, nitrite, acetylcholinesterase, and TNF-α and IL-6 were determined. Oral administration of MECA significantly reversed LPS-induced memory impairment in the YMT and NORT. MECA significantly reduced LPS-induced elevated malondialdehyde and nitrite, while preventing depletion of GSH and catalase in the PFC and HPC sections of the brain. Acetylcholinesterase activity is also reduced. MECA (100 mg/kg) significantly reduced IL-6 and TNF-α levels in PFC and HPC of LPS-treated rats. This study showed that the methanol extract of Cnidoscolus aconitifolius has significant protective effect against lipopolysaccharide-induced memory impairment via mechanisms related to inhibition of neuroinflammation and oxidative stress.
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Omogbiya Adrian Itivere,Ben-Azu Benneth,Eduviere Anthony Taghogho,Eneni Aya-Ebi Okubo,Nwokoye Prisilla O.,Ajayi Abayomi Mayowa,Umukoro Solomon 한국독성학회 2021 Toxicological Research Vol.37 No.3
This study investigated the effect of high doses of monosodium glutamate (MSG), a known food additive on hepatic, memory and locomotor functions in mice, and the ameliorative potentials of Jobelyn ® (JB), a unique dietary supplement. Twenty four male Swiss mice divided into 4 groups (n = 6) were given MSG (2, 4 and 8 g/kg) or normal saline (10 mL/kg) orally for 14 days. In the intervention study, another set of 30 male Swiss mice distributed into 5 groups (n = 6) received normal saline, MSG (8 g/kg) alone or in combination with JB (5, 10 and 20 mg/kg) orally, for 14 days. Memory and locomotor functions as well as brain oxido-nitrergic stress biomarkers were then assessed in both studies. The hepatic oxido-nitrergic stress biomarkers, liver enzymes functions and histomorphology of the liver were also assessed. MSG (2, 4 and 8 g/kg) produced memory dysfunction, hyperlocomotion, increased malondialdehyde and nitrite levels accompanied by decreased antioxidant status in the brain and hepatic tissues. MSG-treated mice had increased hepatic enzyme activities (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and distorted cyto-architectural integrity of the liver. These findings further suggest that MSG compromised hepatic functioning, which might also contribute to its neurotoxicity. However, JB (5, 10 and 20 mg/kg, p.o) attenuated the memory deficit, hyperlocomotion, increased oxido-nitrergic stress responses in the brain and hepatic tissues induced by MSG (8 g/kg, p.o). JB also normalized hepatic enzymes activities and histomorphological changes in MSG-treated mice. Taken together, JB mitigated MSG-induced toxicity through mechanisms relating to enhancement of cellular antioxidant-machineries and normalization of hepatic enzymatic functions.
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