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Ahmad, Taufiq,Parray, Shabir Ahmad,Ahmad, Naseem,Khan, Javed Ahmad,Zohaib, Sharique Cellmed Orthocellular Medicine and Pharmaceutical 2019 셀메드 (CellMed) Vol.9 No.1
Bronchial asthma is one of the most common chronic diseases globally and currently affects approximately 300 million people worldwide. As per scientific data, approximately 10-12% of adults; and 15% of children are affected by the disease. The increasing global prevalence of the disease imposes a high health care costs into its mechanisms and treatment. Unani system of medicine (USM) is a well known traditional therapy for number of diseases since ancient times. Time has proved that USM has a special role in treatment of chronic diseases, due its special Usooleillaj (Line of treatment). Dhiq al-Nafas (bronchial asthma) is also considered as a chronic disease. Since ancient times, the disease was cured by number of single as well as compound formulations by renowned Unani scholars. This review provides a comprehensive summary of medicinal plant throughout the world, with reference to renowned Unani scholars and physicians for treatment of Dhiq al-Nafas. A number of Unani single and compound drugs, highly efficacious and safe drugs are available for the asthma. The data were taken from classical literature of USM, Modern reference books & electronic journals. The recent information was collected from different authentic search engines. This review will provide the centuries therapeutic information's of classical literature and recent scientific studies of 12 herbal drugs mentioned in USM, which will help the academia, clinicians, research scholars and post graduate students from Unani Medicine, Traditional & Complementary Medicine and other related disciplines, having research interest or work in the Unani medicine.
Herbal pathies (Unani, Ayurveda) need to review their way of research
Parray, Shabir ahmad,Parray, Zahoor ahmad,Zohaib, Sharique,Iqbal, Syed mohd faisal,Ahmad, Suhail Cellmed Orthocellular Medicine and Pharmaceutical 2017 셀메드 (CellMed) Vol.7 No.1
World health organization has recently published a strategic plan for the development and promotion of traditional system of medicine. Herbal pathies especially Unani and Ayurvedic systems of medicines have great scope in this aspect. But, there are several problems with these pathies in the current era, as the way of research and identification is still on classical system. The correct identification of medicinal plant is one of the major problems in both the system. This should be corrected with the modern tools and techniques. The various types of data including recent discoveries, economical growth, ethnobotanical literature and extremely rapid increase in herbal journals and books have emerged great scope for these pathies. At the same time several challenges and threats are present including herb-drug interaction, false reports, toxicity studies etc. In this review paper, opportunities, threats, and researches to be focused will be discussed.
New prospective approaches in controlling the insect infestation in stored grains
Ahmad Mir Shabir,Bashir Mir Mudasir,Ahmad Shah Manzoor,Mumtaz Hamdani Afshan,Valiyapeediyekkal Sunooj Kappat,Phimolsiripol Yuthana,Mousavi Khaneghah Amin 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.2
After harvest, food grains are kept in storage facilities for longer periods. Grain infestation during storage causes a significant loss in quality and market value. Various chemical methods have been implemented to control insect infestation in stored grains. However, the chemical fumigants for insects have been limited due to the resistance of insects, environmental concerns, and adverse effects on human health. Therefore, there is a need for viable alternatives for insect disinfestation, which can be residue-free and acceptable at the national and international markets. The new techniques used in the grain industry for insect control during storage gave promising results with high mortality. New methods, such as cold plasma, are becoming a safer tool for the disinfestation of stored grains. The new techniques are rapid and can be applied to bulk material without affecting the quality of grains.
Shabir Ahmad Ganai 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
Histone deacetylases (HDACs) regulate geneexpression by creating the closed state of chromatin viahistone hypoacetylation. Histone acetylation deregulationcaused by aberrant expression of classical HDACs leads toimprecise gene regulation culminating in various diseasesincluding cancer. Histone deacetylase inhibitors (HDACi),the small-molecules modulating the biological function ofHDACs have shown promising results in inducing cellcycle arrest, differentiation and apoptosis in tumour models. HDACi do not show desired cytotoxic effect whenused in monotherapy due to triggering of various resistancemechanisms in cancer cells emphasizing the desperate needof novel strategies that can be used to overcome suchchallenges. The present article provides intricate detailsabout the novel HDACi dacinostat (LAQ-824) againstmultiple myeloma and acute myeloid leukaemia. The distinctmolecular mechanisms modulated by dacinostat inexerting cytotoxic effect against the defined malignancieshave also been detailed. The article also explains thestrategy that can be used to circumvent the conventionaltherapy resistant cases and for enhancing the therapeuticefficacy of dacinostat for effective anticancer therapy.
( Shabir Ahmad ),( Seung Yeup Lee ),( Raees Khan ),( Hyun Gi Kong ),( Geun Ju Son ),( Nazish Roy ),( Kihyuck Choi ),( Seon-woo Lee ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.9
Ralstonia solanacearum causes bacterial wilt in a wide variety of host plant species and produces a melanin-like blackish-brown pigment in stationary phase when grown in minimal medium supplemented with tyrosine. To study melanin production regulation in R. solanacearum, five mutants exhibiting overproduction of melanin-like pigments were selected from a transposon (Tn) insertion mutant library of R. solanacearum SL341. Most of the mutants, except one (SL341T), were not complemented by the original gene or overproduced melanins. SL341T showed Tn insertion in a gene containing a conserved domain of eukaryotic transcription factor. The gene was annotated as a hypothetical protein, given its weak similarity to any known proteins. Upon complementation with its original gene, the mutant strains reverted to their wild-type phenotype. SL341T produced 3-folds more melanin at 72 h post-incubation compared with wild-type SL341 when grown in minimal medium supplemented with tyrosine. The chemical analysis of SL341T cultural filtrate revealed the accumulation of a higher amount of homogentisate, a major precursor of pyomelanin, and a lower amount of dihydroxyphenylalanine, an intermediate of eumelanin, compared with SL341. The expression study showed a relatively higher expression of hppD (encoding hydroxyphenylpyruvate dioxygenase) and lower expression of hmgA (encoding homogentisate dioxygenase) and nagL (encoding maleylacetoacetate isomerase) in SL341T than in SL341. SL341 showed a significantly higher expression of tyrosinase gene compared with SL341T at 48 h post-incubation. These results indicated that R. solanacearum produced both pyomelanin and eumelanin, and the novel hypothetical protein is involved in the negative regulation of melanin production.
Integral mean estimates for some operator preserving inequalities
Shabir Ahmad Malik 강원경기수학회 2024 한국수학논문집 Vol.32 No.3
In this paper, some integral mean estimates for the polar derivative of a polynomial with complex coefficients are proved. We will see that these type of estimates are new in this direction and discuss their importance with respect to existing results comparatively. In addition, the obtained results provide valuable insights into the behavior of integrals involving operator preserving inequalities.
( Shabir Ahmad Bhat ),( B. Nataraju ) 한국잠사학회 2005 International Journal of Industrial Entomology Vol.10 No.2
Lamerin breed of the silkworm, Bombyx mori L. for Northeastern India hosts a vertically transmitted microsporidian parasite for generations, which does not harm significantly the cocoon production. The transversally infected progenies do not exhibit marked external sign or symptom. The microspordian causes inapparent infection and over (80%) of the infected progeny survives and spin cocoons. There is possibility of co-existence between the breed and the associated micosporidian parasite. To evaluate the impact of the microsporidian on breed the present study was conducted in respect of tranovarial transmitted (observed as T1), secondarily infected (observed as T2) and healthy silkworm (observed as T3). The larval and pupal mortality was 12% and 6% in T1 and 10% and 3% in T2 batch, while in case of T3 batch there was no mortality. Significant changes were also observed in single cocoon weight, single shell weight, denier, reelibility, raw silk recovery % and neetness. There is no significant impact of the infection on the fecundity and hatchability. The hatchability of the eggs laid by healthy or infected moths are equall as much as control but the progeny had the infection transmitted from the parent.
SHABIR AHMAD,Khan Salman,Shah Ibrar Ali,Nadeem Muhammad Faisal,Jan Sadaqat,Whangbo Taegkeun 한국컴퓨터산업협회 2023 Human-centric Computing and Information Sciences Vol.13 No.-
Fog computing evolved in 2012 and extended conventional cloud computing services to the Internet of Things (IoT) applications. Real-time applications require fast response to satisfy their quality-of-service requirements. However, cloud computing generates communication latency, which is unacceptable for real-time applications. Fog computing eliminates latency sensitivity by providing services at the edge to IoT users. However, the number of IoT users is increasing exponentially; thus, tasks are generated dynamically and stochastically. Fog computing is a resource-constrained paradigm, unlike the cloud; therefore, adequate resource utilization and task scheduling are challenging. This article proposes a novel framework for Internet of Medical Things (IoMT) applications based on load balancing and task scheduling to minimize overhead latency. To realize the proposed framework, we implement a modified particle swarm optimization (MPSO) technique for delay-sensitive IoMT applications. The proposed algorithm is implemented and evaluated using the iFogSim modeling toolkit. The evaluation is based on performance metrics of execution time delay, execution cost, energy consumption, and network bandwidth consumption as utility functions. Experimental results based on the proposed technique show significant improvements in the performance of IoMT applications (up to 20%, 30%, and 15% in terms of delay, cost, energy, and network, respectively), compared with their counterparts. Moreover, the proposed technique based on MPSO improves resource utilization by up to 80%.