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RISS 인기검색어
- 검색키워드
- 저자 : Abedi Zahra (검색결과 3 건)
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A review of the neuroprotective effects of andrographolide in Alzheimer's disease
Abedi Zahra,Basri Hamidon,Hassan Zurina,Mat Liyana Najwa Inche,Khaza’ai Huzwah,Mohamad Nur Afiqah 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.2
Alzheimer’s disease, characterized by amyloid beta peptides and neurofibrillary tangles, is the most prevalent cause of demen-tia. Nowadays, some novel medicines being developed have displayed more illustrious therapeutic efficacies in Alzheimer’s disease. Recent studies have found andrographolide exhibiting therapeutic efficacy in a variety of Alzheimer’s disease models. Andrographolide is a traditional herbal medicine compound extracted from Andrographis paniculata. Evidence has shown that andrographolide reduces amyloid beta aggregation and suppresses neuroinflammatory response and synaptic dysfunction by reversing the microglia-mediated production of pro-inflammatory cytokines as well as Alzheimer’s disease-associated reduction in synaptic proteins. In the present review, the pharmacological effects of andrographolide are summarized and its mechanism of action against Alzheimer’s disease is discussed to discover the possibilities of andrographolide for Alzhei-mer’s disease prevention and therapy.
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Peiyuan Zuo,Desirée Leistenschneider,Yuna Kim,Zahra Abedi,Douglas G. Ivey,Xuehua Zhang,Weixing Chen 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-
This investigation is aimed at determining the conditions for the oxidation/stabilization of asphaltenefibers through extensive physicochemical characterization and evaluation of mechanical properties ofthe resulting carbon fibers. Melt spinning was used to fabricate green fibers using asphaltenes, from bothstraight solvent-de-asphalting (SDA) processing and subsequent thermal treatment. Thermal pretreatmentof SDA asphaltenes was found to yield much improved carbon fiber properties. An oxidation treatmentof HT300-derived (thermal pretreatment at 300 C) carbon fibers provided the best mechanicalproperties with an average tensile strength of 1130 MPa and an average Young’s modulus of 71 GPa. Thermal treatment of SDA asphaltenes led to much lower sulfur content in both oxidized and carbonizedfibers when oxidation was performed at 300 C. BET, XPS, and XRD analyses showed that carbon fibersfabricated from treated asphaltenes with improved mechanical properties had a lower surface area, lowerpore volume, higher amount of stable functional groups than SDA asphaltene-derived carbon fibers.
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Zavarzadeh, Parisima Ghaffarian,Bonyadi, Morteza,Abedi, Zahra Korea Genome Organization 2022 Genomics & informatics Vol.20 No.3
We described a clinical, laboratory, and genetic presentation of a pathogenic variant of the CYP1B1 gene through a report of a case of primary congenital glaucoma and a trio analysis of this candidate variant in the family with the Sanger sequencing method and eventually completed our study with the secondary/incidental findings. This study reports a rare case of primary congenital glaucoma, an 8-year-old female child with a negative family history of glaucoma and uncontrolled intraocular pressure. This case's whole-exome sequencing data analysis presents a homozygous pathogenic single nucleotide variant in the CYP1B1 gene (NM_000104:exon3:c.G1103A:p.R368H). At the same time, this pathogenic variant was obtained as a heterozygous state in her unaffected father but not her mother. The diagnosis was made based on molecular findings of whole-exome sequencing data analysis. Therefore, the clinical reports and bioinformatics findings supported the relation between the candidate pathogenic variant and the disease. However, it should not be forgotten that primary congenital glaucoma is not peculiar to the CYP1B1 gene. Since the chance of developing autosomal recessive disorders with low allele frequency and unrelated parents is extraordinary in offspring. However, further data analysis of whole-exome sequencing and Sanger sequencing method were applied to obtain the type of mutation and how it was carried to the offspring.
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