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- 검색키워드
- 저자 : A. Prakasam (검색결과 3 건)
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Antihyperglycemic Activity of Piper betle Leaf on Streptozotocin-Induced Diabetic Rats
K.V. Pugalendi,P. Santhakumari,A. Prakasam 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.1
Piper betle, an indigenous medicinal plant, has a folk (Siddha and Ayurvedha) reputation in the rural south-ern India. The present study was carried out to evaluate the effect of P. betleon glucose metabolism since it is consumed asbetel-quid after meals. Plasma levels of glucose and glycosylated hemoglobin and activities of liver hexokinase and gluco-neogenic enzymes such as glucose-6-phosphatase and fructose-1,6-bisphosphatase in control and streptozotocin (STZ) dia-betic rats were assayed. Oral administration of leaf suspension of P. betle (75 and 150 mg/kg of body weight) for 30 days re-sulted in significant reduction in blood glucose (from 205.00. 10.80 mg/dL to 151.30. 6.53 mg/dL) and glycosylatedhemoglobin and decreased activities of liver glucose-6-phosphatase and fructose-1,6-bisphosphatase, while liver hexokinaseincreased (P. .05), in STZ diabetic rats when compared with untreated diabetic rats. P. betleat a dose of 75 mg/kg of bodyweight exhibited better sugar reduction than 150 mg/kg of body weight. In addition, protection against body weight loss ofdiabetic animals was also observed. The effects produced by P. betlewere compared with the standard drug glibenclamide.Thus, the present study clearly shows that P. betle intake influences glucose metabolism beneficially.
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Gunaseelan Mani,A. Leema Maria Prakasam,Lakshmi Narayan Mishra,Vishnu Narayan Mishra 경남대학교 수학교육과 2021 Nonlinear Functional Analysis and Applications Vol.26 No.5
In this paper, we introduce the concepts of an orthogonal generalized F -contraction mapping and prove some fixed point theorems for a self mapping in an orthogonal metric space. The given results are generalization and extension some of the well-known results in the literature. An example to support our result is presented.
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K.V. Pugalendi,R. Saravanan,A. Prakasam,B. Ramesh 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.4
Piper betle L. is a commonly used masticatory in Asia. This study was carried out to investi-gate the hepatoprotective and antioxidant properties of P. betle,using ethanol intoxication asa model of hepatoxic and oxidative damage. Ethanol-treated rats exhibited elevation of he-patic marker enzymes and disturbances in antioxidant defense when compared with normalrats. Oral administration of P. betle extract (10, 20, or 30 mg/kg body weight) for 30 dayssignificantly (P , .05) decreased aspartate aminotransferase (AST), alanine aminotransferase(ALT), thiobarbituric acid reactive substances (TBARS), and lipid hydroperoxides in ethanoltreated rats. The extract also improved the tissue antioxidant status by increasing the levelsof nonenzymatic antioxidants (reduced glutathione, vitamin C, and vitamin E) and the activ-ities of free radical detoxifying enzymes such as superoxide dismutase, catalase, and glu-tathione peroxidase in liver and kidney of ethanol-treated rats. The highest dose of P. betleextract (30 mg/kg body weight) was most effective. The results were comparable with theknown hepatoprotective drug, silymarin. These results indicate that P. betle could afford asignificant hepatoprotective and antioxidant effect.197
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