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Miura, Kenji,Jin, Jing Bo,Lee, Jiyoung,Yoo, Chan Yul,Stirm, Vicki,Miura, Tomoko,Ashworth, Edward N,Bressan, Ray A,Yun, Dae-Jin,Hasegawa, Paul M Americ 2007 The Plant cell Vol.19 No.4
<P>SIZ1 is a SUMO E3 ligase that facilitates conjugation of SUMO to protein substrates. siz1-2 and siz1-3 T-DNA insertion alleles that caused freezing and chilling sensitivities were complemented genetically by expressing SIZ1, indicating that the SIZ1 is a controller of low temperature adaptation in plants. Cold-induced expression of CBF/DREB1, particularly of CBF3/DREB1A, and of the regulon genes was repressed by siz1. siz1 did not affect expression of ICE1, which encodes a MYC transcription factor that is a controller of CBF3/DREB1A. A K393R substitution in ICE1 [ICE1(K393R)] blocked SIZ1-mediated sumoylation in vitro and in protoplasts identifying the K393 residue as the principal site of SUMO conjugation. SIZ1-dependent sumoylation of ICE1 in protoplasts was moderately induced by cold. Sumoylation of recombinant ICE1 reduced polyubiquitination of the protein in vitro. ICE1(K393R) expression in wild-type plants repressed cold-induced CBF3/DREB1A expression and increased freezing sensitivity. Furthermore, expression of ICE1(K393R) induced transcript accumulation of MYB15, which encodes a MYB transcription factor that is a negative regulator of CBF/DREB1. SIZ1-dependent sumoylation of ICE1 may activate and/or stabilize the protein, facilitating expression of CBF3/DREB1A and repression of MYB15, leading to low temperature tolerance.</P>
The Arabidopsis SUMO E3 Iigase SIZ1 controls phosphate deficiency responses
Miura, Kenji,Rus, Ana,Sharkhuu, Altanbadralt,Yokoi, Shuji,Karthikeyan, Athikkattuvalasu S.,Raghothama, Kashchandra G.,Bae k, Dongwon,Koo, Yoon-Duck,Jin, Jing-Bo,Bressan, Ray A.,Yun, Dae-Jin,Hasegawa, Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.
Plants sense phosphate (Pi) deficiency and initiate signaling that controls adaptive responses necessary for Pi acquisition. Herein, evidence establishes that AtSIZ1 is a plant small ubiquitin-like modifier (SUMO) E3 ligase and is a focal controller of Pi starvation-dependent responses. T-DNA insertional mutated alleles of AtSIZ1(At5g60410) cause Arabidopsis to exhibit exaggerated prototypical Pi starvation responses, including cessation of primary root growth, extensive lateral root and root hair development, increase in root/shoot mass ratio, and greater anthocyanin accumulation, even though intracellular Pi levels in siz1 plants were similar to wild type. AtSIZ1 has SUMO E3 ligase activity in vitro, and immunoblot analysis revealed that the protein sumoylation profile is impaired in siz1 plants. AtSIZ1-GFP was localized to nuclear foci. Steady-state transcript abundances of Pi starvation-responsive genes AtPT2, AtPS2, and AtPS3 were moderate but clearly greater in siz1 seedlings that in wild type, where Pi is sufficient. Pi starvation induced the expression of these genes to the same extent in siz1 and wild-type seedlings. However, two other Pi starvation-responsive genes, AtlPS1 and AtRNS1, are induced more slowly in siz1 seedlings by Pi limitation. PHR1, a MYB transcriptional activator of AtIPS1 and AtRNS1, is as AtRNS1 sumoylation target. These results indicate that AtSIZ1 is a SUMO E3 ligase and that sumoylation is a control mechanism that acts both negatively and positively on different Pi deficiency responses.
Richard, E.,Okumura, K.,Abe, K.,Haga, Y.,Hayato, Y.,Ikeda, M.,Iyogi, K.,Kameda, J.,Kishimoto, Y.,Miura, M.,Moriyama, S.,Nakahata, M.,Nakajima, T.,Nakano, Y.,Nakayama, S.,Orii, A.,Sekiya, H.,Shiozawa, American Physical Society 2016 Physical Review D Vol.94 No.5
<P>A comprehensive study of the atmospheric neutrino flux in the energy region from sub-GeV up to several TeV using the Super-Kamiokande (SK) water Cherenkov detector is presented in this paper. The energy and azimuthal spectra, and variation over time, of the atmospheric nu(e) + (nu) over bar (e) and nu(mu) + (nu) over bar (mu) fluxes are measured. The energy spectra are obtained using an iterative unfolding method by combining various event topologies with differing energy responses. The azimuthal spectra depending on energy and zenith angle, and their modulation by geomagnetic effects, are also studied. A predicted east-west asymmetry is observed in both the nu(e) and nu(mu) samples at 8.0 sigma and 6.0 sigma significance, respectively, and an indication that the asymmetry dipole angle changes depending on the zenith angle was seen at the 2.2 sigma level. The measured energy and azimuthal spectra are consistent with the current flux models within the estimated systematic uncertainties. A study of the long-term correlation between the atmospheric neutrino flux and the solar magnetic activity cycle is performed, and a weak preference for a correlation was seen at the 1.1 sigma level, using SK-I-SK-IV data spanning a 20-year period. For several particularly strong solar activity periods, corresponding to Forbush decrease events, no theoretical prediction is available but a deviation below the typical neutrino event rate is seen at the 2.4 sigma level. The seasonal modulation of the neutrino flux is also examined, but the change in flux at the SK site is predicted to be negligible, and, as expected, no evidence for a seasonal correlation is seen.</P>
The Arabidopsis SUMO E3 ligase SIZ1 controls phosphate deficiency responses.
Miura, Kenji,Rus, Ana,Sharkhuu, Altanbadralt,Yokoi, Shuji,Karthikeyan, Athikkattuvalasu S,Raghothama, Kashchandra G,Baek, Dongwon,Koo, Yoon Duck,Jin, Jing Bo,Bressan, Ray A,Yun, Dae-Jin,Hasegawa, Paul National Academy of Sciences 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.102 No.21
<P>Plants sense phosphate (Pi) deficiency and initiate signaling that controls adaptive responses necessary for Pi acquisition. Herein, evidence establishes that AtSIZ1 is a plant small ubiquitin-like modifier (SUMO) E3 ligase and is a focal controller of Pi starvation-dependent responses. T-DNA insertional mutated alleles of AtSIZ1 (At5g60410) cause Arabidopsis to exhibit exaggerated prototypical Pi starvation responses, including cessation of primary root growth, extensive lateral root and root hair development, increase in root/shoot mass ratio, and greater anthocyanin accumulation, even though intracellular Pi levels in siz1 plants were similar to wild type. AtSIZ1 has SUMO E3 ligase activity in vitro, and immunoblot analysis revealed that the protein sumoylation profile is impaired in siz1 plants. AtSIZ1-GFP was localized to nuclear foci. Steadystate transcript abundances of Pi starvation-responsive genes AtPT2, AtPS2, and AtPS3 were moderate but clearly greater in siz1 seedlings than in wild type, where Pi is sufficient. Pi starvation induced the expression of these genes to the same extent in siz1 and wild-type seedlings. However, two other Pi starvation-responsive genes, AtIPS1 and AtRNS1, are induced more slowly in siz1 seedlings by Pi limitation. PHR1, a MYB transcriptional activator of AtIPS1 and AtRNS1, is an AtSIZ1 sumoylation target. These results indicate that AtSIZ1 is a SUMO E3 ligase and that sumoylation is a control mechanism that acts both negatively and positively on different Pi deficiency responses.</P>
Real-time supernova neutrino burst monitor at Super-Kamiokande
Abe, K.,Haga, Y.,Hayato, Y.,Ikeda, M.,Iyogi, K.,Kameda, J.,Kishimoto, Y.,Miura, M.,Moriyama, S.,Nakahata, M.,Nakano, Y.,Nakayama, S.,Sekiya, H.,Shiozawa, M.,Suzuki, Y.,Takeda, A.,Tanaka, H.,Tomura, T. North-Holland ; Elsevier Science Ltd 2016 Astroparticle physics Vol.81 No.-
<P>We present a real-time supernova neutrino burst monitor at Super-Kamiokande (SIC). Detecting supernova explosions by neutrinos in real time is crucial for giving a clear picture of the explosion mechanism. Since the neutrinos are expected to come earlier than light, a fast broadcasting of the detection may give astronomers a chance to make electromagnetic radiation observations of the explosions right at the onset. The role of the monitor includes a fast announcement of the neutrino burst detection to the world and a determination of the supernova direction. We present the online neutrino burst detection system and studies of the direction determination accuracy based on simulations at SK. (C) 2016 Elsevier B.V. All rights reserved.</P>
Abe, K.,Bronner, C.,Pronost, G.,Hayato, Y.,Ikeda, M.,Iyogi, K.,Kameda, J.,Kato, Y.,Kishimoto, Y.,Marti, Ll.,Miura, M.,Moriyama, S.,Nakahata, M.,Nakano, Y.,Nakayama, S.,Okajima, Y.,Orii, A.,Sekiya, H. American Astronomical Society 2017 The Astrophysical journal Vol.850 No.2
<P>We present the results of a search in the Super-Kamiokande (SK) detector for excesses of neutrinos with energies above a few GeV that are in the direction of the track events reported in IceCube. Data from all SK phases (SK-I through SK-IV) were used, spanning a period from 1996 April to 2016 April and corresponding to an exposure of 225 kiloton-years. We considered the 14 IceCube track events from a data set with 1347 livetime days taken from 2010 to 2014. We use Poisson counting to determine if there is an excess of neutrinos detected in SK in a 10 degrees search cone (5 degrees for the highest energy data set) around the reconstructed direction of the IceCube event. No significant excess was found in any of the search directions we examined. We also looked for coincidences with a recently reported IceCube multiplet event. No events were detected within a +/- 500 s time window around the first detected event, and no significant excess was seen from that direction over the lifetime of SK.</P>
h Ninomiya,T. Imai,T. Fujii,T. Suzuki,T. Fujita,T. Yamamoto,Y. Uesugi,Y. Kamada,Y. Takase,Y. Kudo,Y. Miura,Y. Ikeda,Y. M. Miura,A. Shimizu,A. Kimura,A. Morioka,A. Nishimura,A. Sagara,G. Kurita,H. Kubo 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
The NCT Program, in which the present JT-60U is being modified into a superconducting coil machine, is discussed under nationwide collaboration in Japan. Its mission is to establish high-beta steady-state operation for DEMO and to contribute to ITER. NCT is designed to have potential to investigate such research.
RADIATION SAFETY STUDIES AT TOHOKU UNIVERSITY CYRIC
Yamadera, M. Baba A.,Miura, T.,Aoki, T.,Hagiwara, M.,Kawata, N. 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.3
A brief introduction is presented on the radiation safety studies at Tohoku University Cyclotron & Radioisotope Center. Studios on two subject are described; (1) measurement of the thick target neutron yield and radioisotope production / activation cross section for ten's of MeV neutrons and ions using K=110 Tohoku University cyclotron to provide basicdata fur accelerator shielding, and (2) development of techniques for high sensitive radiation detection and profile measurement using an Imaging Plate which is a high sensitive two-dimensional radiation sensor. Application of the Imaging Plate techniques to localization of very weak radioactivity and to neutron profile measurement is described.
Search for neutral Q-balls in Super-Kamiokande II
Super-Kamiokande Collaboration,Takenaga, Y.,Abe, K.,Hayato, Y.,Iida, T.,Ishihara, K.,Kameda, J.,Koshio, Y.,Minamino, A.,Mitsuda, C.,Miura, M.,Moriyama, S.,Nakahata, M.,Obayashi, Y.,Ogawa, H.,Shiozawa, North-Holland Pub. Co 2007 Physics letters. Section B Vol.647 No.1
A search for Q-balls has been carried out in Super-Kamiokande II with 541.7 days of live time. A neutral Q-ball passing through the detector can interact with nuclei to produce pions, generating a signal of successive contained pion events along a track. No candidate for successive contained event groups has been found in Super-Kamiokande II, so we obtain upper limits on the flux of such Q-balls.
Search for Boosted Dark Matter Interacting with Electrons in Super-Kamiokande
Kachulis, C.,Abe, K.,Bronner, C.,Hayato, Y.,Ikeda, M.,Iyogi, K.,Kameda, J.,Kato, Y.,Kishimoto, Y.,Marti, Ll.,Miura, M.,Moriyama, S.,Nakahata, M.,Nakano, Y.,Nakayama, S.,Okajima, Y.,Orii, A.,Pronost, G American Physical Society 2018 Physical Review Letters Vol.120 No.22
<P>A search for boosted dark matter using 161.9 kt yr of Super-Kamiokande IV data is presented. We search for an excess of elastically scattered electrons above the atmospheric neutrino background, with a visible energy between 100 MeV and 1 TeV, pointing back to the Galactic center or the Sun. No such excess is observed. Limits on boosted dark matter event rates in multiple angular cones around the Galactic center and Sun are calculated. Limits are also calculated for a baseline model of boosted dark matter produced from cold dark matter annihilation or decay. This is the first experimental search for boosted dark matter from the Galactic center or the Sun interacting in a terrestrial detector.</P>