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Helicobacter Pylori 에 의해 誘發되는 胃疾患에 對한 考察
李淵月,孫彰奎,趙鍾寬 대전대학교 韓醫學연구소 2000 한의학연구소 논문집 Vol.8 No.2
This paper presents a study for a development of the oriental medical treatment on the gastric disease caused by Helicobacter Pylori. Helicobacter Pylori is observed in stomach mucosa and it is caused gastric disease via various routes. Helicobacter Pylori is spread generally mouth to mouth by men. So it is related to personal health condition or life style. The treatment of Helicobacter Pylori is an antibiotic combination therapies, but it caused a problem of side effect and drug resistant. In the oriental medical treatment, an immunopotentiation reduces an infective rate of Helicobacter Pylori and prevents a progressive gastric disease.
Differential Expression of Gene Profiles in MRGX -treated Lung Cancer
이연월,Yong-Kyun Kwon,Seung-Yeul Lee,Hwan-Soo Kang,성정석,조종관,유화승,Seungjin Shin,Jong-Soon Choi,장익순 대한약침학회 2013 Journal of pharmacopuncture Vol.16 No.3
Objectives: Modified regular ginseng extract (MRGX) has stronger anti-cancer activity-possessing gensenoside profiles. Methods: To investigate changes in gene expression in the MRGX-treated lung cancer cells (A549), we examined genomic data with cDNA microarray results. After completing the gene-ontology-based analysis, we grouped the genes into up-and down-regulated profiles and into ontology-related regulated genes and proteins through their interaction network. Results: One hundred nine proteins that were up- and down-regulated by MRGX were queried by using IPA. IL8, MMP7 and PLAUR and were found to play a major role in the anti-cancer activity in MRGX-treated lung cancer cells. These results were validated using a Western blot analysis and a semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis. Conclusions: Most MRGX-responsive genes are up-regulated transiently in A549 cells, but down-regulated in a sustained manner in lung cancer cells.
소화불량증을 호소하여 1개 한방병원에 내원한 환자 130례에 대한 임상특성 분석
이연월 ( Yeonweol Lee ) 대전대학교 한의학연구소 2015 혜화의학회지 Vol.24 No.1
Objective: This study aimed to explore the clinical feature of patients with dyspepsia who were treated by an Oriental internal medicine. Methods: We analyzed 130 patients who visited an Korean Medicine Hospital for their dyspepsia-related symptoms, from March 1, 2014 until to February 28, 2015 Results: The sex composition was consisted of 31.5% man and 68.5% woman, and 85.6% of outpatient and 14.4% of inpatient. The 39.2% of patients showed chronic complain (>6 months), and the main causes included stress and fatigue for 46.2% and 31.5% respectively. The accompanied symptoms were mainly fatigue (40.0%), insomnia (36.9%), abnormal stool (34.6%), upper back pain (31.5%), and headache (28.5%). The improvement rate was 68.5% while other (31.5%) showed no change of dysplasia. Conclusion: This study created an important information of patients with dysplasia, which will be critically helpful for development of Korean Medicine-based therapeutics in the future.
이연월 ( Lee Yeon Weol ),유화승 ( Yoo Hwa Seung ),조종관 ( Cho Chong Kwan ) 대전대학교 한의학연구소 2016 혜화의학회지 Vol.25 No.1
Objectives : The purpose of this study was to present the clinical guidelines for Korean medical treatment of Irritable Bowel Syndrome Methods : Reports for Korean medical treatment of Irritable Bowel Syndrome were collected, analyzed and summarized from the Electronic journal search since 2000. Results : In Korean medicine treatment of irritable bowel syndrome used herbs, acupuncture, moxibustion, herbal acupuncture, and auricular acupuncture. Herb medicines were administered according to the patient`s case by a prescription of considering physical condition and symptoms. Acupuncture and moxibustion therapies stimulate the median points of LR(足厥陰肝經), ST(足陽明胃經), LI(手陽明大腸經), SI(手太陽 小腸經). The assessment items for Korean medical treatment of Irritable Bowel Syndrome were abdominal symptoms, defecation, autonomic nervous system changes, stress, Live blood condition and mental health. Conclusions : Through continued research need to develop better treatment strategies for Korean treatment of Irritable Bowel Syndrome.