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Dopamine D2 Receptor효능제인 TNPA의 신장작용
고석태(Suk-Tai Ko),황명성(Myung-Sung Hwang) 대한약학회 2001 약학회지 Vol.45 No.2
The dopaminergic receptors were considered of two distinct subtypes, D1 and D2, each having different fuction. The present study was attempted to investigate the effects of R(-)-2,10,11-trihydroxy-N-n-propylnoraphine(TNPA), a dopamine D2 against, on renal function in dog. TNPA decrease in osmolar clearance(Cosm) and urinary excretion of sodium and potassium(ENa and EK. It also increased reabsorption rates of sodium and potassium in renal tubules(RNa, RK) without any changes in glomerular filtration rate(GFR), renal plasma flow(RPF) and free water clearance(CH2O). TNPA(0.5~1.5 mcg/kg/min) infused into a renal artery decrease urine flow both in the experimental and control kidneys. TNPA(1.5-5.0mcg/kg) administered via the carotid artery also greately exhibitied antidiuresis even at intraveously ineffective doses. Changes of renal function by TNPA given into both renal artery and the carotid artery were almost the same aspect to those induced by intraveonous TNPA. These results obtained from the present study suggest that TNPA produces antidiuresis by increasing the reabsorption rates of electrolytes ub renal tubules, mainly distal tubule, through changing of central fuction.
Dopamine D2 Receptor 효능제인 TNPA의 중추적 항이뇨작용 기전
고석태(Suk Tai Ko),황명성(Myung Sung Hwang) 대한약학회 2001 약학회지 Vol.45 No.4
It has been demonstrated previously that R(-)-2,10,11-trihydroxy-N-n-propylnora porphine (TNPA), a dopamine D2 receptor agonist, produced the antidiuresis through changes of central function in dog. This study was investigated about effects of renal denervation and raclopride, a dopamine D2 receptor antagonist, on the antidiuresis of TNPA in order to elicidate the mechanism involved in this central anticiuresis induced by TNPA. Antidiresis exhibited by mPh given into the vein or into carotid artery was not influenced by renal denervation, whereas antidiuresis of TNPA administered into carotid artery was blocked almost perfectly by raclopride pretreated into carotid artery: From these observations it is concluded that central antidiuresis induced by TNPA is brought about through activation of dopamine D2 recap- tor localized in brain, not related to renal nerve activity.
니트릭옥사이드의 합성 억제제인 NG-니트로-L-아르기닌의 신장작용
고석태(Suk Tai Ko),유강준(Kang Jun Yu),황명성(Myung Sung Hwang) 大韓藥學會 1998 약학회지 Vol.42 No.5
This study was performed in order to investigate the effect of renal function of NG-nitro-L-arginine (L-NOARG), inhibitor of nitric oxide (NO) synthase, in dog and rabbit. L-NOARG, when given intravenously in dogs, exhibited the decrease in urine flow (vol), renal plasma flow (RPF), osmolar clearance (Cosm) and amounts of sodium and potassium excreted in urine(ENa, EK). These renal functions of L-NOARG showed the same aspect in rabbit, too. L-NOARG, when administered into a renal artery, showed the same pattern as was obtained when given intravenously in both experimental and control kidney in dog. L-NOARG administered into the carotid artery showed the decrease in Vol, RPF, ENa, in a low doses that did not show any effect when given intravenously. Above results suggest that L-NOARG produces antidiuretic action in dog and rabbit, and these antidiuretic actions may be mediated by central action.