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Anti-Influenza Activity of Betulinic Acid from Zizyphus jujuba on Infl uenza A/PR/8 Virus
홍은혜,송재형,강교빈,성상현,고현정,양희정 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4
Betulinic acid, a pentacyclic triterpene isolated from Jujube tree (Zizyphus jujuba Mill), has been known for a wide range of biological and medicinal properties such as antibacterial, antimalarial, anti-infl ammatory, antihelmintic, antinociceptive, and anticancer activities. In the study, we investigated the antiviral activity on infl uenza A/PR/8 virus infected A549 human lung adenocarcinoma epithelial cell line and C57BL/6 mice. Betulinic acid showed the anti-infl uenza viral activity at a concentration of 50 μM without a signifi cant cytotoxicity in infl uenza A/PR/8 virus infected A549 cells. Also, betulinic acid signifi cantly attenuated pulmonary pathology including increased necrosis, numbers of infl ammatory cells and pulmonary edema induced by infl uenza A/PR/8 virus infection compared with vehicle- or oseltamivir-treated mice in vivo model. The down-regulation of IFN-γ level, which is critical for innate and adaptive immunity in viral infection, after treating of betulinic acid in mouse lung. Based on the obtained results, it is suggested that betulinic acid can be the potential therapeutic agent for virus infection via anti-infl ammatory activity.