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Positron Emission Tomography-Computed Tomography (PET-CT)로 전이를 확인한 머켈세포암
홍승필 ( Seung Phil Hong ),지재홍 ( Jae Hong Ji ),전수영 ( Soo Young Jeon ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.1
Merkel cell carcinoma is a rare and lethal skin cancer that mostly occurs in aged persons who are over 60 years old as a dome-shaped purple nodule on the sun-exposed areas of the head, neck and extremities. The mortality rate is high because this tumor has a propensity for local recurrence, regional lymph node metastasis and distant metastasis. Therefore, rapid and precise diagnosis and staging are critical to improve the prognosis. We reported here on a 68-year old man with Merkel cell carcinoma on his right cheek and he had regional cervical lymph node metastasis, as was detected by PET-CT scanning. (Korean J Dermatol 2010;48(1):51∼55)
The Clinical Assessment of Cosmetic Products for The Management of Atopic Dermatitis
홍승필 ( Seung-phil Hong ) 한국피부장벽학회 2016 한국피부장벽학회지 Vol.18 No.1
Atopic dermatitis (AD) is a chronic skin disease featured by defects in the skin barrier function and cutaneous inflammation, in which transepidermal water loss is increased and the ability of the stratum corneum to hold water is impaired. The diminished barrier function seen in patients with AD contributes to their striking susceptibility to colonization and infection of pathogens and an increased penetration of allergens. Because it is known that moisturizers play an important role in improving skin barrier and preventing skin inflammation, the use of moisturizers is strongly emphasized in the treatment of AD. In this situation, clinicians have to choice and recommend a proper moisturizer for their patient among many products in the market. Accordingly, the suitability of assessment methods in the clinical study with cosmetic products is importance issue to accept the moisturizer as a therapeutic agent in the treatment of AD. This section will review representative clinical reports with cosmetic products (moisturizers) in patients with AD and then discuss about the proper clinical assessment methods.
홍승필 ( Seung Phil Hong ),김민정 ( Min Jeong Kim ),전수영 ( Soo Young Jeon ),박하나 ( Ha Na Bak ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.6
Lichen striatus and linear lichen planus are rare disorders that can be confused because they share similar clinical and histopathologic findings. We report a case of lichen striatus on the left wrist and fingers in a 54-year-old woman, who was initially diagnosed with linear lichen planus. She had overlapping clinico-histopathologic features of both lichen striatus and linear lichen planus. To discriminate between the two disorders, careful histological and clinical evaluations are needed, especially when a lichen striatus-like eruption occurs in adults. (Korean J Dermatol 2007;45(6):629∼631)
홍승필 ( Seung Phil Hong ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Epidermal layers of the skin include, the stratum corneum(SC), stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale. These layers reflect the differentiation process of keratinocyte. The SC is approximately 60% keratin by dry weight. Keratins are members of a family of proteins called intermediate filaments that form part of the cytoskeleton of nucleated cells and are major structural proteins of skin, hair, and nail. When keratins are made by the cell, an acidic type I keratin is made at the same time as a neutral to basic type II keratin. Keratin filaments contain types I & II keratins in a 1:1 molar ratio. According to the differentiation stage and anatomical location, keratinocytes produce particular keratins, such as K5/K14 (K15) in the basal layer, K1/K10 in suprabasal layers, K2 in granular layer, and K9, K6a/b, K16, K17 in palmoplantar skin. Besides structural support, keratins are involved in cell and tissue growth, skin pigmentation, keratinocyte migration and immunomodulation. The SC corneocytes with their resistant cell envelopes and keratin microfibrils are considered to be the bricks, and the layers of lipids found between the cells are considered to be the mortar. The lipid "mortar" is the main barrier to water passing out through the SC. The permeability of lipid soluble molecules is modeled by considering them to wind their way around the corneocyte bricks by diffusing through the lipid mortar. Both the bricks and the mortar of the SC are produced by keratinocytes at the SG at which keratinocytes release the lipids of the mortar into the space between the cells as they are being transformed into the corneocytes "bricks." Barrier insults stimulate not only repair responses, but also initiate cytokine cascade; IL-1, TNF and IL-6 are stimulators of lipid synthesis. The dermoepidermal junction is an undulating basement membrane that adheres the epidermis to the dermis. It is composed of 2 layers, the lamina lucida and lamina densa. The lamina lucida is thinner and lies directly beneath the basal layer of epidermal keratinocytes. The thicker lamina densa is in direct contact with the underlying dermis. These structures are the target of immunologic injury in bullous disorders. The junction serves the following functions: (1) epidermal-dermal adherence, (2) mechanical support for the epidermis, and (3) a barrier to the exchange of cells and of some large molecules across the junction.
홍승필 ( Seung Phil Hong ),최응호,안성구 한국피부장벽학회 2009 한국피부장벽학회지 Vol.11 No.1
The human skin is constantly exposed to microbial pathogens but infections only rarely occur. The stratum corneum (SC) (i.e., the outermost layer of human skin) composed of corneocytes and a matrix of intercellular lipids playing an essential role as the skin`s protective barrier. In order to protect the epidermis and to maintain its integrity, the SC uses various strategies, including enzymatic reactions, colonization by bacterial flora, immune signaling, antimicrobial lipids and peptides, low pH, antioxidants, and natural moisturizing factor(s). Innate cutaneous immunity is a primary system for protection against infection, and antimicrobial peptides (AMPs) expressed in skin are essential defense molecules. Cutaneous AMPs are multifunctional molecules, killing the microbes or inhibit their growth with a broad-spectrum of antimicrobial activity. Their amino acid composition, amphipathicity, cationic charge and small size allow them to attach to and insert into microbial membrane bilayers to form pores. Also, they are playing a role as signaling molecules, which could mediate host inflammation. Several skin diseases such as atopic dermatitis, psoriasis, and rosacea are associated with AMP dysfunction. In atopic eczema, for example, cathelicidin expression is suppressed, whereas in rosacea cathelicidin peptides are abnormally processed to forms that induce cutaneous inflammation and a vascular response. In psoriasis cathelicidin peptide converts self-DNA to a potent stimulus in an autoinflammatory cascade. Cutaneous vitamin D3 system and pro-inflammatory cytokines (IL-1, TNF-α, and IFN-γ) are known as a major factor involved in the regulation of antimicrobial barrier as well as permeability barrier. The strategies for control or application of AMPs might provide new approaches in both medicine and related industry. This minireview reports on current understanding of the antimicrobial barrier function of the skin.
여드름 환자의 얼굴에서 피지량, 여드름 병변수, 모공 형광밀도와의 상관 관계
홍승필 ( Seung Phil Hong ),한병관 ( Byung Kwan Han ),정병조 ( Byung Jo Jung ),배영우 ( Young Woo Bae ),최응호 ( Eung Ho Choi ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.9
Background: Porphyrins produced by Propionibacterium acnes exhibit an orange-red fluorescence spot on the pilosebaceous pore under UVA light. Based on this characteristic, the recently developed photographic technique, ``fluorescence photography``, warrants mention in the context of acne, especially in the assessment of the presence of bacteria and sebum output. Objective: The aim of this study was to assess the relationship between sebum output and acne lesion counts with fluorescent density (% fluorescence area). We discuss the possibility of the use of fluorescence photography as a new tool to evaluate acne and sebum levels. Methods: Total of 39 subjects, 29 males and 10 females, were recruited for this prospective study. To estimate fluorescent density, fluorescent facial images were taken and analyzed with digital fluorescent imaging system and an image analysis program. The sebum output level was measured with a Sebumeter(R). Numbers of acne lesions were counted. Also, sebum output and fluorescent images were compared before and after the use of a facial cleanser containing 1% triclosan. Results: Sebum output level was significantly associated with fluorescent density, but not with the number of acne lesions. However, in the group using triclosan containing cleanser, fluorescent density decreased, while sebum level increased. Therefore, fluorescent density seems to be influenced mainly by the density of P. acnes. Conclusion: Fluorescence density correlates with P. acnes mostly followed by sebum output level. Digital fluorescent imaging system is considered as a useful tool to assess sebum excretion as well as colonization of P. acnes. (Korean J Dermatol 2007;45(9):890∼897)