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인삼(人蔘)사포닌의 동물행동(動物行動)에 대(對)한 작용(作用)
홍사악(Hong, S.A.),박찬웅(Park, C.W.),김재훈(Kim, J.H.),홍순근(Hong, S.K.),장현갑(Chang, H.K.),김명석(Kim, M.S.) 대한약리학회 1974 대한약리학잡지 Vol.10 No.2
Results of an experiment on the behavior of rats and mice in order to explore the possible pharmacological actions of Panax ginseng upon the central nervous system can be summarized as follows: 1. Spontaneous motor activity. In the case of mice, those groups who were administered 2.5 mg and 5.0mg of ginseng saponin per kilogram of body weight were observed to have increased their activity compared with the control group, while the 50.0 mg and 100.0 mg per kilogram body weight groups demonstrated lower levels of activity, with the peak of activity appearing at 30 minutes after administration of drugs. In the case of rats, those groups of animals who were given injections in the dosage of 2.5 mg, 5.0 mg and 50.0 mg per kilogram body weight demonstrated higher activity than the control group, while the 100.0 mg per kilogram group appeared to have decreased in their activity, with the peak action appearing 30 minutes after the administration of ginseng saponin. The 50.0 mg per kilogram group demonstrated no significant differential. 2. General behavior analysis. In the case of mice, decrease in sleeping component of behavior and increase in the walking and roaring components, compared those with the control group, turned out to be a common phenomenon among the groups who were administered 2.5 mg, 5.0 mg and 50.0 mg of ginseng saponin per kilogram body weight, with the 5.0 mg per kilogram group standing out of all the other groups in terms of their reactions. In the case of rats, ginseng saponin appeared to reduce sleeping component with 2.5 mg, 5.0 mg and 50.0 mg per kilogram body weight groups, while increased the walking and rearing components. It was observed that administratoin of ginseng saponin in a dose of 2.5 mg per kilogram appeared to markedly increase the lying and grooming components of animal behavior. 3. Open-field exploratory behavior. Adminstration of ginseng saponin to mice in doses of 5.0 mg, 50.0 mg and 100.0 mg per kilogram body weight decreased activity, but increased their exploratory behavior. In the case of rats, however, administration of ginseng saponin in the doses of 2.5 mg and 5.0 mg per kilogram body weight markedly increased their activities, while decreased activities with the 50.0 mg per kilogram and 100.0 mg per kilogram groups. The exploratory behavior of rats appeared to have decreased, while grooming increased ramarkably. 4. The above findings from a series of experiment appear to suggest a stimulating effect on the central nervous system when ginseng saponin is administered in small doses, but that larger doses might result in an inhibitory effect, though differential results can be anticipated with modification of experimental conditions.
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한용남(Y. N. Han),박은희(E. H. Park),김충원(C. J. Lim),임창진(C. W. Kim),이동권(D. K. Rhee),김두하(D. H. Kim),장진규(J. G. Jang),홍순근(S. K. Hong) 한국생약학회 1980 생약학회지 Vol.11 No.1
인삼의 유효성분인 인삼사포닌은 12종이 순수 단리되어 그 화학구조가 이미 밝혀졌으며, 또한 단리된 순수사포닌의 약물학적 특성에 관한 보고도 누적되고 있다. 최근 경구투여용 인삼제제의 임상연구가 활발이 진행되고 있으며 노인병, 당뇨병, 저혈압 등의 질환에 치료효과가 인정되고 있다. 이러한 인삼의 치료효과를 보다 넓게 응용하기 위해서 정제된 인삼사포닌의 주사제 개발이 요청되고 있다. 이에 연자 등은 정제 인삼사포닌 주사제의 개발을 위한 독성시험을 진행 중에 있으면 금번 학회에는 주사용량을 결정하기 위한 금성 및 아급성 독성시험의 결과를 보고하고자 한다. 정제 인삼사포닌의 LD50는 890㎎/㎏체중(흰쥐, 피하, 24시간)이었고, 아급성 독성시험을 위해 각종 용량을 흰쥐에 4주간 피하주사하고 체중변화, 혈청학적 검사를 실시한 결과 7.7, 24㎎/㎏체중에서는 정상적 대사활동을 촉진시켰고, 240㎎/㎏체중 이상에서 체중감소, 단백질 합성 억제, 간 중량 증가 등 중독현상을 발견하였다.
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