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라미부딘 치료 중인 만성 B형 간염 바이러스 감염 환자에서 B형 간염 바이러스 역전사효소의 변이 양상
이상용 ( Sang Yong Lee ),허정 ( Jeong Heo ),최철웅 ( Cheul Woong Choi ),이주호 ( Joo Ho Lee ),김광하 ( Gwang Ha Kim ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),조몽 ( Mong Cho ),양웅석 ( Ung Suk Yang ),장현정 ( Hyun Jung 대한소화기학회 2003 대한소화기학회지 Vol.41 No.6
Background/Aims: Lamivudine resistant hepatitis B viruses (HBV) by mutations of YMDD motif in the HBV reverse transcirptase are very common in the patients with long-term lamivudine therapy. We investigated the pattern of mutations in and outside of YMDD motif of HBV reverse transcriptase gene during lamivudine therapy in patients with chronic hepatitis B infection. Methods: The study included 80 patients with chronic hepatitis B infection. To determine mutations in the HBV reverse transcriptase, the nucleotide 581-870 of the HBV reverse transcriptase was amplified and analyzed by direct sequencing method. Results: Amino acid changes were detected in 45 (56%) out of 80 patients. YMDD mutants were detected in 62% (28/45) and amino acid changes were detected outside of YMDD motif in 38% (17/45). M552I (82%, 23/28) was more common than M552V (18%, 5/28) in YMDD mutants. L528M was noted in 27% (12/45). F569Y (13%, 6/45), S571A (13%, 6/45), I572V (18%, 8/45) were common amino acid changes. Conclusions: Mutations were frequently detected outside of YMDD motif as well as YMDD motif of HBV reverse transcriptase gene in patients with lamivudine therapy. Most of the mutations in outside of YMDD motif were combined with YMDD mutants. No consistent mutation was found outside of YMDD motif in lamivudine resistant patients. (Korean J Gastroenterol 2003;41:480-485)
류마티스 관절염에서 발생한 Cerebral Aspergillosis
이태근 ( Tae Kun Lee ),최재훈 ( Jae Hoon Choi ),최철웅 ( Cheul Woong Choi ),이상용 ( Sang Yong Lee ),이준희 ( Jun Hee Lee ),이정욱 ( Joung Wook Lee ),김상수 ( Sang Soo Kim ),김성일 ( Sung Il Kim ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
We report a case of aspergillosis of the central nervous system in patient with rheumatoid arthritis (RA). A 46-year-old woman with 20-year history of RA and on treatment with corticosteroid, hydroxychloroquine and methotrexate, was admitted because of drowsiness, dizziness and dysarthria. On admission, physical examination and laboratory data showed, among other findings, disappearance of pupil reflex, positive Babinski and Chaddock reflex. Magnetic resonance imaging (MRI) of brain showed multiple high signal intensity lesion on medulla, pons, midbrain, basal ganglia, internal capsule, thalamus and hypothalmus. Stereotactic brain biopsy was performed and biopsy specimen revealed an invasive Aspergillus.