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산화질소-합성효소 유전자의 다형성이 급성 관동맥 증후군과 이형 협심증 환자에 미치는 영향의 차이
최수연(Soo Yeon Choi),유경훈(Kyung Hoon Yoo),박진식(Jin Sik Park),채인호(In Ho Chae),김효수(Hyo Soo Kim),손대원(Dae Won Son),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shick Choi),이영우(Young Woo 대한내과학회 2000 대한내과학회지 Vol.58 No.1
N/A Background : Nitric oxide, also known as endothelial derived relaxing factor(EDRF), regulates the vascular tone and inhibits the proliferation of vascular smooth muscle cells and platelet adhesions and endothelium-leukocyte interactions. Thus, nitric oxide may be involved in the pathogenesis of atherosclerosis and vasospasm. We analyzed the genotype distributions of two eNOS gene polymorphisms in normal healthy Koreans and compared it with those in the patients with acute coronary syndrome and variant angina. Methods : We analyzed the two eNOS polymorphisms (eNOS A/B polymorphism is the variable numbers of tandem repeat in intron 4 and eNOS T/G polymorphism is a mis-sense mutation in exon 7) using PCR and clinical characteristics of the risk factors for coronary artery disease in 142 normal healthy Koreans and 164 patients with acute coronary syndrome and 104 patients with variant angina. Results : The genotype distribution of A/B polymorphism of eNOS gene, A/A, A/B, B/B was 4.9%, 21.1%, 74% in control group and 2.4%, 12.8%, 84.8% in the patients with acute coronary syndrome(p=0.02) and 2.9%, 16.3%, 80.8% in the patients with variant angina(p=NS), respectively. The genotype distribution of T/G polymorphism of eNOS gene, T/T, T/G, G/G was 1.4%, 15.5%, 83.1% in control group and 0.6%, 21.3%, 78.1% in the patients with acute coronary syndrome(p=NS) and 0%, 18.3%,81.7% in the patients with variant angina(p=NS), respectively. The odds ratio for acute coronary syndrome of non B/B(A/A & A/B) to B/B was 0.489 (95% CI : 0.257∼0.928). We found that age, sex (male), diabetes mellitus, hyperlipidemia, smoking, B/B genotype were independent risk factors for acute coronary syndrome. But, in variant angina, smoking was the only significant independent risk factor(odds ratio=5.934, 95% CI 2.843-12.388, p<0.05). Conclusion : The B/B genotype frequency of eNOS gene was significantly higher in patients with acute coronary syndrome than in normal controls. But neither A/B nor T/G polymorphism of eNOS gene was associated with variant angina. These results suggest that eNOS gene may play some roles in the pathogenesis of ACS rather than vasospasm.(Korean J Med 58:19-27, 2000)
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건강한 한국 성인에서 lipoprotein lipase 유전자의 유전적 다형성이 혈중 지질농도와 체질량 지수에 미치는 영향
박진식(Jin Sik Park),성지동(Ji Dong Sung),채인호(In Ho Chae),김효수(Hyo Soo Kim),주재란(Jae Ran Ju),손대원(Dae Won Son),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shick Choi),이영우(Young Woo Lee) 대한내과학회 2000 대한내과학회지 Vol.58 No.1
N/A Background : Lipoprotein lipase(LPL) plays a pivotal role in triglyceride-rich lipoprotein metabolism. It removes TG-rich lipoprotein from circulation by hydrolysing TG and produces active form of HDL. It also affects the development and maintenance of obesity by regulating the fatty acid metabolism of the adipose tissue. Many studies about the association of the genetic variation of LPL and dyslipidemia have been performed, but the results were not consistent. We tried to characterize the phenotypes of the LPL genetic variation in Korean. Methods : Healthy Korean adults (n=110) were genotyped for Hind III/Pvu II RFLP and Ser447Ter mutation of the LPL gene by PCR-digestion method. We investigated the association of the genetic variations with the lipids, the lipoprotein concentrations and the body mass index(BMI). Results : The allele frequencies of Hind III RFLP, Pvu II RFLP and Ser447Ter mutation were H1:H2=33%:67%, P1:P2=40%:60% and Ser447:Ter447=90%:10%. Ser447Ter mutation carriers had higher HDL cholesterol level than non-carriers (59±10mg/dl versus 53±11mg/dl, p=0.049) and the Pvu II RFLP is associated with increased body mass index.(P1P1:P1P2:P2P2 = 22.1±2.0 kg/m2: 23.5±2.7 kg/m2: 24.5±2.6 kg/m2, p=0.003) Conclusion : The genetic variations of the LPL gene in healthy Korean adult resulted in increased HDL cholesterol and increased BMI. These results were different from previous studies. This difference may reflect the racial difference from the diet and the linkage disequilibrium (Korean J Med 58:57-66, 2000)
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A METHOD OF SUMMATION OF MULTIPLE FOURIER SERIES
Choi, Yun-Shick 서울대학교 1955 서울대학교 論文集 Vol.2 No.-
單一 Fourier 級數를 二重或은 多重 Fourier 級數로의 擴張과 其總和方法과 可和法에 對하여는 曾往 여러가지 文獻에서 吟味하였다. 卽 參考文獻表中 番號 〔3〕,〔4〕,〔5〕,〔6〕,〔7〕,〔8〕,〔9〕,〔10〕,〔13〕의 論文中에 있다. 그들 文獻中의 總和方法은 여러가지 形으로 되어있다. f(χ_1,……,χ_n)의 Fourier級數를 다음形으로 記하고 (1) f(χ)∼∑a_pi…_pn eχpi(p_1χ_1+…+p_nχ_n) 但 a_p1……_pn=1/(2π)^n∫^π_-π…∫^π_-πf(χ) eχp{i(p_1χ_1+……+p_nχ_n)}dt 또 다음과같이 定義하면 (2) s_k(χ)=∑_(v^2<k^2)(1-V^2/R^2) a_p1……_pn eχpi(p_1χ_1+…+p_nχ_n) 但은 v^2=p_1^2+…+p_n^2 S_R(χ)은 級數 (1)의 球形和 Riesz 平均이다. (3) S_m1……_mn(χ)= S_m1……_mn(χ)는 級數 (1)의 矩形和의 Cesaro 平均이다. 以上 一般形外에 Rogosinski는 部分和의 모아짜기 方法을 誘導하였다. 그것은 Cesaro 平均의 變形이고, 其後얼마지나, J.G.Herriot는 二重 Fourier 級數의嚴格한可和法을 探求하기 爲하여 二重 Fourier 級數의 總和法을 擴張하였다. 이것은 文獻 〔3〕,〔4〕에 있다. 其文獻에 依한 硏究에 있서 本人은 多重 Fourier 級數의 展開의 其사람의 方法이 容易치아니한것을 發見하였다. 그러나 그것은 大段히 重要한 것이라고 보았다. 그리하여 本論文 第一節에는 그것의 擴張을 실었고, 第一節, 第二節에는 不連續函數의 多重 Fourier 級數에 對한 應用을 展開시켰다.
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