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최오철,뢰영성,박선동 대한본초학회 2004 大韓本草學會誌 Vol.19 No.4
Objective : Acetaminophen, which causes acute liver injury in humans and animals, has made useful inducer of hepatoxicity for studying hepatopreventive drugs. Joagumhwan is known as one of the hepatopreventive drugs. However, its mechanism of recovery of hepatoxicity treated with acetaminophen is poorly understood. this study was performed to observe the antioxidative effect of Joagumhwan extract and its several combination group. Methods : This study was performed to research the antioxidant activities and hepatoxicity of Joagumhwan extract and its several combination groups. The experimental group was divided into 3 groups : Joagumhwan Ⅰ(JGH Ⅰ), Joagumhwan Ⅱ(JGH Ⅱ), Joagumhwan Ⅲ (JGH Ⅲ). Results : JGHⅠ reduced the amount of lipid peroxide in serum and liver by inducing antioxidative enzymes such as catalase, and increased the amount of glutathion-s-transferase in vitro in vivo. Morever, JGH Ⅲ also had antioxidative effect in vivo. JGH Ⅰshowed significant effect on recovery of hepatoxicity (GOT. GPT, γ-GPT, ALP, LDH, bilirubin) and cell survival. Conclusion : Therfore, these results suggest that JGH Ⅰ is very useful therapatic agest for recovery of hepatoxicity by acetaminophen overdose.
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대황감초음자(大黃甘草飮子)와 그 구성약물군(構成藥物群)이 Alloxan 유도 당뇨(糖尿) 백서(白鼠)의 혈청 조성 및 항산화 효과에 미치는 영향
고원도,곽동걸,신화석,최오철,박선동,Go Won-Do,Gwak Dong-Gul,Shin Hwa-Seog,Choi Oi-Chul,Park Sun-Dong 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
The purpose of this study was to reseach the effect of Daehwanggamchoeumja(大黃甘草飮子) and its component groups on diabetes, free radicals, and antioxidants system in Alloxan-induced diabetic rats. The experimental group was divided into three groups: Daehwanggamchoeumja(DG), and its components groups, Gamdutang (Gamcho&Daedu; DG-I) and Daehwanggamchotang(DG-2). The results were obtained as follows: 1. In the study of effect on diabetic metabolic dysfunction(Glucose, Triglyceride, Total Cholesterol, HDL Cholesterol, Total Protein, Albumin, Creatine, BUN), only DG has a significant effect. 2. In the study on free radical scavenging effect in vitro(the suppressing effect on peroxidation of linoleic acid on concentration, the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system, inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2Fe^{2-}$system, and the effect on Nitrate reductase activity), DG and DG-2 have more effect than DG-l relatively. 3. In the study on antioxidants system in vivo(The level of serum LPO, The level of hepatic LPO, Catalase, GSH, GST), only DG has a significant effect. These results suggest that Daehwanggamchoeumja(大黃甘草飮子) has an effect on diabetes, peroxidative damage by free radical, so it seems to be useful to prevent and treat diabetes. The mechanisms of these are supposed to be involved in antioxidant and three drugs' cooperative synergy effect.
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