http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
7-엑소메칠렌 세팔로스포라네이트 유도체의 합성과 beta-락타메이즈 억제작용
이종민(Jong Min Lee),최수항(Su Hang Choi),이현수(Hyun Soo Lee),임채욱(Chae Uk Im),임철부(Chul Bu Yim) 대한약학회 1999 약학회지 Vol.43 No.6
7-Oxocephalosporanate 1 was treated with phosphonium salts 2~4 by Wittig reaction to afford 7-exomethylene cephalosporanates 5-7. They were oxidized to sulfones 8-10 with mCPBA. Deprotection of benzhydryl 7-exomethylene cephalosporanate with AlCl3 and NaHC03 gave sodium salts of 7-exomethylene cephalosporanates 11-16. The beta-lactamase inhibitory activity of synthesized compounds 11~16 were compared with sulbactam, tazobactam and clavulanic acid against Type I, II, III, IV and TEM-2 beta-lactamase in vitro. Compound 15 showed more potent activity than sulbactam and clavulanic acid against Type III, IV beta-lactamase enzyme.
장홍(Hong Jang),최수항(Su-hang Choi),이재형(Jay Hyung Lee) 제어로봇시스템학회 2014 제어·로봇·시스템학회 논문지 Vol.20 No.3
This article reviews various state estimation methods for nonlinear systems, particularly with a perspective of a process control engineer. Nonlinear state estimation methods can be classified into the following two categories: stochastic approaches and eterministic approaches. The current review compares the Bayesian approach, which is mainly a stochastic approach, and the MHE (Moving Horizon Estimation) approach, which is mainly a deterministic approach. Though both methods are reviewed, emphasis is given to the latter as it is particularly well-suited to highly nonlinear systems with slow sampling rates, which are common in chemical process applications. Recent developments in underlying theories and supporting numerical algorithms for MHE are reviewed. Thanks to these developments, applications to large-scale and complex chemical processes are beginning to show up but they are still limited at this point owing to the high numerical complexity of the method.
Piperazinyl Quinolone계 유도체의 합성 및 항균작용
임철부(Chul Bu Yim),이영운(Young Woon Lee),최수항(Su Hang Choi),염정록(Jeong Rok Youm),허인회(In Hoi Huh) 대한약학회 1991 약학회지 Vol.35 No.6
A number of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-substitutedcarbamyl-1-piperazinyl) quinoline [or 1,8-naphthyridine]-3-carboxylic acid and their pivaloyloxymethyl esters were prepared. The compounds synthesized were evaluated for antibacterial activity in vitro against Escherichia coli, Bacillus subtilis, Proteus vulgaiis, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. Among those 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylcarbamyl-l-piperazinyl) quinoline-3-carboxylic acid [1] and 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylcarbamyl-1-piperazinyl)1,8-naphthyridine-3-carboxylic acid [6] showed the most potent in vitro antibacterial activity.