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Dithiocarbohydrazone류의 합성과 항균작용에 관한 연구(I) 2-Formylpyridine Dithiocarbohydrazone류 및 이들의 Cu(II) 착물
최보길(Bo Gil Choi) 대한약학회 1986 약학회지 Vol.30 No.2
In order to study 2-formylpyridine dithiocarbohydrazones (DTCH''s) and their Cu(II) chelates as potential effective antimicrobial agents, twelve new compounds of six DTCH''s and their Cu(II) chelates were synthesized. The compositions of Cu(II) chelates were determined on the basis of the data obtained from elemental analysis, electronic and IR spectrophotometry, and other method. They were tested for antimicrobial activity in vitro against a gram-positive, seven gram-negative bacterial species and three fungal species. DTCH''s exhibited high antibacterial activity against the gram-positive Staphylococcus aureus, but low activity against the various gram-negative bacterial species. In contrast to DTCH'S, their Cu(II) chelates exhibited higher antibacterial activity against St. aureus, but weaker, if any, activity against the gram-negative bacterial species. Both DTCH''s and their Cu(II) chelates showed relatively potent antifungal activity against Cryptococcus neoformans, but weak activity against Candida albicans and Candida pseudotropicalis.
항암제 안티네오플라스톤 A10의 동족체합성 및 항암 활성
최보길(Bo Gil Choi),서희경(Hee Kyoung Seo),김옥영(Ok Young Kim),정병호(Bung Ho Chung),오인준(In Jun Oh),조원제(Won Jea Cho),천승훈(Seung Hoon Cheon),박민수(Min Soo Park),최상운(Sang Un Choi),이정옥(Chong Ock Lee) 대한약학회 1997 약학회지 Vol.41 No.3
Some analogs and their Mannich bases of Antineoplaston A10 (A10) were synthesized. Chemical yield for the 2-(or 3-)thienyl, benzol, and phenylpropionyl analogs were high but 1-naphthyl analog was synthesized in low yield. the Mannich bases formation of these analogs with morpholine went verywell compared to other bases. 1-Naphthyl, 4-nitrobenzoyl, and phenylpropionyl analogs of A10 showed weak in vitro activity but the other A10 analogs showed weaker or no activity at 10-1000mcg/ml. But their Mannich bases containing A10analogs showed good in vitro activity compared to simple A10 analogs.
Ditertiary Diamine의 Regiospecific N-, N''-Monoalkyl화 반응
장지향(Ji Hyang Jang),최보길(Bo Gil Choi),정병호(Byung Ho Chung) 대한약학회 1990 약학회지 Vol.34 No.4
N-Monoalkylations of ditertiary diamines succeed best in nitromethane or ethanol at low temperature. Unsymmetrical 1,2-diaminoethane, 1,3-diaminopropane and piperazine compounds react selectively under these conditions at the sterically less hindered nitrogen atom.
장지향(Ji Hyang Jang),김욱(Wook Kim),최보길(Bo Gil Choi),정병호(Byung Ho Chung) 대한약학회 1992 약학회지 Vol.36 No.4
Four new derivatives of 2-(3-phenoxyphenyl)propionic acid, widely used as non-sterioidal antiinflammatory and analgesic drug were synthesized.
L-1,3-Dioxolane 및 L-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성
홍준희(Joon Hee Hong),박정하(Jeong Ha Park),송지연(Ji Yeon Song),최보길(Bo Gil Choi),정병호(Byung Ho Chung),김중협(Joong Hyup Kim),이종교(Chong Kyo Lee),정원근(Won Keun Chung),천문우(Moon Woo Chun) 대한약학회 1994 약학회지 Vol.38 No.6
(+/-)Dioxolane-T and(+/-)BCH-189 are know to possess anti-HIV activities, and less to xicities compared to other dideoxynucleoside AIDS drugs. We have synthesized 34 different enantiomerically pure nucleosides by glycosylation of L-1,3-dioxolanyl acetate and L-1,3-oxathiolanyl acetate sugar moieties with uracil or 6-azauracil with alkyl chains(C1-C3) on 5 or 6 position.
D-1,3-Dioxolane 및 D-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성
홍준희(Joon Hee Hong),차마리(Ma Rie Cha),신성은(Seong Eun Shin),최보길(Bo Gil Choi),정병호(Byung Ho Chung),김중협(Joong Huyup Kim),이종교(Chong Kyo Lee),정원근(Won Keun Chung),천문우(Moon Woo Chun) 대한약학회 1994 약학회지 Vol.38 No.6
We synthesized D-1,3-dioxolanyl acetate from D-mannose using Frazer-Reide reaction and D-1,3-oxathiolanyl acetate from either D-mannose or D-galactose in good yields. These acetates were conjugated with various disilylated pyrimidine base using trimethylsilyl trifluoromethane sulfonate as a Lewis acid catalyst to obtain 32 different D-nucleosides.
D-1,3-디옥솔란 및 L-1,3-옥사티올란 5-페닐세레닐 피리미딘 뉴크레오사이드의 합성
유정만(Jung Man Yoo),문현주(Hyun Joo Moon),정병호(Byung Ho Chung),최보길(Bo Gil Choi),홍준희(Joong Hee Hong),천문우(Moon Woo Chun) 대한약학회 1996 약학회지 Vol.40 No.1
Eight new D-1.3-dioxolanyl and L-1,3-oxathiolanyl nucleosides containing 5-phenyl- selenyl pyrimidine bases which are expected to have antiviral activity were synthesized. Condensation of D-1,3-dioxolane acetate and L-1,3-oxathiolane acetate with 5-phenylselenyl pyrimidines gave anomeric mixtures of their nucleosides which were separated by silicagel column chromatography.
항진균제 Naftifine 구조와 관련된 알릴아민류의 합성
김욱(Wook Kim),박은주(Eun Ju Park),서희경(Hee Kyong Seo),신부안(Boo Ahn Shin),최보길(Bo Gil Choi),정병호(Byung Ho Chung) 대한약학회 1993 약학회지 Vol.37 No.3
Eight new derivatives of allylamine which are related to naftifine and expected to have antifungal activity were synthesized. Schiff base 2a-2d and 2''e-2''h were obtained by conventional methods using trans-cinnamylamine or trans-cinnamaldehyde. The reduction of azomethine linkage with NaBH4 yielded secondary amine 3a-3h, which were then methylated by means of HCHO and excess NaBH4 or hcooh to give 4a-4h.
CoMFA법을 이용한 3-아릴이소퀴놀린 화합물들의 SK-OV-3 암세포에 대한 가상의 약물 작용 수용체 해석
김의기(Eui Ki Kim),민선영(Sun Young Min),정병호(Byung Ho Chung),천승훈(Seung Hoon Cheon),최보길(Bo Gil Choi),조원제(Won Jea Cho) 대한약학회 2002 약학회지 Vol.46 No.4
We have performed a 3D-QSAR/ CoMFA analysis of the cytotoxic activities of thirty-five 3-arylisoquinoline derivatives against SK-OV-3 tumor cell line. The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross- validated r2 as high as 0.841) was obtained through CoMFA