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안해선,채경래,채권목 대한혈관외과학회 1995 Vascular Specialist International Vol.11 No.1
The deep vein thrombosis causes substantial morbidity and mortality, and increased by the basis for the various diagnostic studies used to confirm a suspected diagnosis. However, patients with deep vein thrombosis who were treated with medical and surgical procedure may have recurrent events or failed. And then, we have need of improved diagnostic and therapeutic techniqe for prevent from pulmonary embolism or obstruction of arterial blood flow. This report is for retrospective statistical review of 40 cases of deep vein thrombosis, who were admitted and treated at Wonkwang University Hospital from Jaunary, 1990 to June, 1994, the following resutls were obtained; 1) The age distribution was between 3rd and 9th decade, the peak incidence of age was the 7th decade(30.0%), and the male to female ratio was about 1: l. 2) The most frequent symptom was swelling(35 cases, 87.5%) followed by pain and tenderness (22 cases, 55.5%), and Homans sign was positive in 11 cases(27.5%). The duration of symptom before admission of majority cases(14 cases, 35.0% ) were within 10 days. 3) The major predisposing factor was previous operation(9 cases, 22.5%) followed by tuberculosis, trauma and malignancy, in order of frequency. 4) The dominant affected site was left (26 cases, 65.0%) and both was 3 cases, the most common level of venous obstruction was femoral vein in 14 cases(35.0%). 5) In the treatments and results, there were 26 cases(65.0%)with heparin and warfarin therapy, the result of good and fair were 14 cases(73.1%) among 19 follow-up patients(73.0%), and remainder was poor. The nine cases(22.5%) were urokinase, heparin and warfarin therapy, the result of good and fair were 5 cases(71.4% among 7 follow-up patients(77.8%) and remainder was poor. 6) The operation was done in 5 cases(7.5%), Palma & Dale operation was undergone in 3 cases and the result of good and fair were 2 cases, and one case was poor. Therombectomy was done in 2 cases, the result of good & fair and poor were each other. Therombectomy was done in 2 cases, the result of good & fair and poor were each other. 7) In the complication of anticoagulants and thrombolytic agents, the most common non- hemorrhgic complication is headache(15.0%) and the main hemorrhagic complication is gum bleeding(10.0%).
Lee, Bok-Soo,Jun, Chang-Duk,Chun, Young-Whan,Paik, Sang-Gi,Cho, Baik-Whan,Choi, Chan,Chae, Kwon-Mook,Chung, Hun-Taeg 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-
The point mutation at a specific site (the third base of codon 249 of exon 7) in the p53 gene was not found in the 8 hepatocellular carcinoma samples from Korean patients. This result is quite different from the report on Chinese and South African patients that showed the point mutations at the same site with the frequency of 50% in hepatocellular carcinoma sample. Even though this particular point mutation was not found in Korean samples, there might be mutations at other sites of p53 gene, because expression of mutated p53 gene was detected in the nuclei of hepatocellular carcinoma samples by using monoclonal antibodies which are specific for mutant-type p53 proteins. Also the change of DNA content was found in the hepatocellular carcinoma samples.