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랫드에서 PMMA와 Cross-Linked Dextran 혼합물의 생체 안전성 및 부피 효과에 대한 연구
장민우 ( Min Woo Jang ),진부갑 ( Bu Kab Jin ),이상훈 ( Sang Hun Lee ),박재홍 ( Jae Hong Park ),류정민 ( Jung Min Ryu ),윤승필 ( Seung Pil Yun ),박성원 ( Sung Won Park ),김형석 ( Heyong Seok Kim ),문창종 ( Chang Jong Moon ),서국현 한국조직공학·재생의학회 2010 조직공학과 재생의학 Vol.7 No.1
This study examined bio-safety and volume-related effect of the mixture of polymethylmethacrylate (PMMA) and Cross-linked Dextran as a soft tissue augmentation. To examine bio-safety and volume-related effect of the mixture of PMMA and Cross-linked Dextran in rat, gross, hematological, and pathohistological examinations were performed in comparison with CRM (R) DX (Cross-linked hyaluronic acid sodium salt, Dextranomere; commercial product) and saline. During the experimental period, there was no dead rats and scratching behavior which is a most common symptom when rejecting foreign body was observed. The volume of injected mixture was maintained sufficiently. Complete blood count(CBC) finding indicated that there were no significant differences in the number of inflammatory cells between control and experimental group. In addition, the parameters of hepatic toxicity (aspartate aminotransferase: AST, alanine transaminase: ALT, alkaline phosphatase: ALP, γ-glutamyl transpeptidase: γ- GTP, lactate dehydrogenase: LDH), renal toxicity (creatinine, blood urea nitrogen: BUN, cholesterol, albumin: ALB, phosphorus), and other organ toxicity (calcium, triglyceride, and creatine phosphokinase: CPK) using serum biochemical analysis did not show the significant differences between the control and experimental group, suggesting that systemic toxicity was not found in liver, kidney, and other organs. Histopathological findings indicated that the subcutaneous tissue had red color microsphere which capsulated by collagen near the injection site. Furthermore, the infiltration of inflammatory cells were not observed in the injected sites of all experimental groups. In conclusion, the mixture of PMMA and Cross-linked Dextran can be a safe substance for soft tissue augmentation maintaining tissue volume.
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