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- 저자 : 주일로(Il Lo Jou) (검색결과 2 건)
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간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 생콩을 첨가 사육한 흰쥐의 이자 ( 膵臟 ) 외분비 기능 및 구조에 관한 연구
김경환(Kyung Hwan Kim),김학산(Hak San Kim),안영수(Young Soo Ahn),주일로(Il Lo Jou) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4
N/A It has been reported that long term feeding of raw soybean which contains heat labile trypsin inhibitor resulted in hypertropby ae well as hyperplasia and in the development of hyperplastic naduIes and adenomas. This response of the pancreas to raw soybean is thought to be mediated largely by the CCK release and loss of feedback inhibition from intestinal pancreatic proteinases. Similar phenomena have afeo been reported by feeding synthetic trypsin inhibitor, camostat (FOY- 305). Moreover, there are changes of seeretory pattern of pancreatic enzymes by feeding trypsio inhibitor. Present study was done to investigate the integral effect of feedig raw soybean for upto two years on the exocrine secretory.function and morphology of pancreas in the rat. The Sprague-Dawley rats of either sex weighing about 70 g at the beginning of study were used. Two kinds of soybean were selected, those are Glycine max Merr. (Muktae) containing high trypsin inhibitor and Phaseolus anguIaris Wight var. nipponeneis Ohwi (Geodu) containing low trypsin inhibitor. Raw soybean flour was fed two days a week ad tib, whereas normaI rat chow was provided rest of the week. For control study the same schedule was applied for heated soybean. The rats were anesthetized with urethane (1.25 g/kg, s.c.) and pancreatic seeretions were colIected from duodenal end of pancreatic duct after proximal biliary duct was ligated. The exocrine pancreas was stimul#ated with secretin (0.5 CU/kg/hr) with or without cholecystokinin octapeptide (CCK-8, 1200 ng/kg/hr). Amylase and trypsin were assayed by the method of Bernfeld (1955) and Hummel (1959), respectively. Separation of enzyme protein was done by HPLC method (Padfield and Case, 1988) using TSK phenyl 5PW hydrophobic interacti,on column. At the end of experiment pancreas was resected and examined by light and electron microscopies. The results are as follows: 1) Feeding raw soybean retarded the growth of rat but increased the pancreas weight. However, there was little differenee to the content of trypsin inhibitor in the soybean. 2) The basal secretion of amylase and trypsin was increased by feeding raw soybean. 3) The CCK-8-Stimulated enzyme secretian was increaeed throughout the experimental period but there was little 6ifference ta the trypsin inhibitor content in the raw soybean.
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임신중 Phenobarbital이 태어난 흰쥐의 이자외분비 기능에 미치는 영향
이선미,홍사석,주일로,강영록 대한소화기학회 1992 대한소화기학회지 Vol.24 No.5
In fetal development, organogenesis and functional developments are much influenced by xenobiotics administered during pregnancy or by maternal disease. In rat, while the critical periods for the morphological abnormalities during development are days 11-14 of gestation, those of functional defects are days 18-22. Phenoliarbftat; frequently used as hypnotics-sedatives as well as anticonvulsants, is transferred to the fetus rapidly througlii the placenta. Also, chronic administration of Phenobarbital causes induction of a hepatic microsomal enzyme systems which are responsible for the biotransformatibn of xenobotcs. It was reported that chronic treatment of Phenobarbital increased the amylase secretion from the pancreas in adult rat. The preseat study, therefore, was undertaken to investiggate the effect of Phenobarbital treatment during pregnancy on the exocrine pancreatic function in neonatal rats. Gravid Sprague-Dlawley rats were injected intraperitoneally once daily with either 50 mg/kg Phenobarbital or saline (1 ml/kg) on days 17-20 of pregnancy. Until 30 days of age, progeny from each litter was sacrified at 3-7 day intervals by decapitation. $quot;floe pancreas and liver were removed and homogenized in saline, and were used for the determination of enzyme activities and protein contents. The enzyme released from the pancreatic slices was measured with or without acetylcholine (10^(-8) M) stimulation. The results are summerized as follows. 1) The body weight of the Phenobarbital treated rats during pregnancy was significantly higher than that of controls. On the other hand, the weight of pancreas or liver was rather decreased by Phenobarbital treatment. 2) The basal releases of the amylase fram the pancreatic slices of both control and Phenobarbital treated groups were high at 3rd postnatal day and then decreased at ?th and 14th days. 3) The amylase releases from the pancreatic slices wre significantly increased in response to acetylcholine stimulation in both groups. From 3rd days these responses were much higher in Phenobarbital treated rats. 4) Compared to enzyme activities at 3rd days, amylase activity was lower at 7th day while trypsin activity was highest at 7th day in control rats. In contrast, tro the contral, treatment of Phenobarbital during pregnancy caused increase in amylase activity in the pancreatic tissue, however the trypsin activity was decreased. 5) The protein content in the tisstae of pancreas and liver was not significantly changed by Phenobarbital treatment. From these results, it is suggested that the phenobarbital treatment during pregnancy exerts significant influence on the postnatal exocrine pancreatic function, and augments the nonparallel secretion of the pancreatic enzymes.
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