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ABO식 혈액형 유전자를 활용한 분자생물학 탐구 프로그램의 개발 및 적용
조재형(Jae-Hyoung Jo),노정욱(Jung-Wook Roh),서단비(Dan-Bi Seo),김완연(Wan-Yeon Kim) 한국교원대학교 뇌기반교육연구소 2020 Brain, Digital, & Learning Vol.10 No.4
In this study, after developing and applying a molecular biology inquiry program using the ABO blood type gene, the effect of the inquiry program on the concept achievement related to molecular biology and genetics and scientific attitudes of students was investigated. Twenty 2nd grade students attending a general high school in Gyeonggi-do participated in the research. Each of them was divided into an experimental group and a control group, and the developed inquiry program was put into the experimental group, and an explanatory class composed of the same contents was put into the control group. Before and after class input, a concept achievement test and a scientific attitude test were conducted, the results of the tests were compared between two groups, and an interview was conducted with the students in the experimental group on the effectiveness of the class. As a result of the research, a 6-hour molecular biology inquiry program was developed that can be easily applied in school. As a result of applying the inquiry program to the students, both concept achievement and scientific attitude showed higher improvement in the mean score of the post-test compared to the pre-test in the experimental group than in the control group, and the score difference was statistically significant. In addition, the positive effect was confirmed in the interview on the effectiveness of the class. On the other hand, among the sub-areas of concept achievement and scientific attitude, the areas that did not show any significant effects were analyzed in depth. Finally, the educational implications of this and the necessity of follow-up studies were discussed.
이종 췌도 이식을 위한 Ba²+-알진산 미세피막화 췌도 형성
박헌석 ( Heon Seok Park ),함동식 ( Dong Sik Ham ),유영혜 ( Young Hye You ),신주영 ( Ju Young Shin ),김지원 ( Ji Won Kim ),조재형 ( Jae Hyoung Jo ),김온유 ( On You Kim ),강길선 ( Gil Son Khang ),윤건호 ( Kun Ho Yoon ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.5
Islet transplantation is one of the promising treatment strategies for the cure of diabetes. However, the hurdles such as shortage of human tissue, immune rejection and recurrence of autoimmunity should be overcome for successful islet transplantation. Xeno-transplantation can be a solution to shortage of human sources. Immune isolation by microencapsulation of islet with alginate polymer could escape the immune injuries. Microencapsulated xenoislet transplantation is a one of the ideal strategies to cure the diabetes. Here, we introduce microencapsulation of islets for successful xenogenic islet transplantation. We achieved optimization of encapsulating condition. First, we demonstrated viability and insulin secreting capacity of encapsulated islets in vitro. We confirmed their ability of maintaining normoglycemia and escaping immune rejection after rat or porcine islet transplantation to diabetic mouse models.