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조양환(Yang-Hwan Cho),이철(Chul Lee),이창규(Chang-Kyu Lee),안철우(Chul-Woo Ahn),박규호(Kyu-Ho Park) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.2Ⅲ
본 논문의 웹 서버 디렉터는 웹 서버의 앞단에 설치되어 과부하 상태에서 서버의 성능 감소를 막는 역할을 한다. 본 논문을 통해 구현된 웹 서버 디렉터는 기존의 아파치와 같은 웹 서버의 수정 없이 그대로 사용하기 때문에, 그 동안 개발되어 온 웹 서버 모듈과 부가 기능을 모두 사용할 수 있는 장점이 있다. 또한, 서버의 I/O 모델로 가장 이상적이라고 검증된 단일 프로세스와 이산사건처리 방식을 채택하여, 일반 웹 서버에 비하여 최고 1.6배의 성능 향상을 보인다. 부가적으로 SYN Flooding 과 같은 악의적인 웹 요청에도 견고한 특성을 보인다.
9∼12개월 영아에서 철 결핍성 빈혈의 조기 검진 필요성
조양환 ( Yang Hwan Cho ),김수영 ( Su Yeong Kim ),이대용 ( Dae Yong Yi ),윤신원 ( Sin Weon Yun ),채수안 ( Soo Ahn Chae ),임인석 ( In Seok Lim ),이나미 ( Na Mi Lee ) 한국정맥경장영양학회 2019 한국정맥경장영양학회지 Vol.11 No.2
Purpose: Growth and development of infants can be periodically assessed through health screening, but iron deficiency anemia, which is common in infants, is difficult to detect by conducting only infant health screening. This study evaluated the prevalence of iron deficiency anemia in infants who visited Chung-Ang university hospital between 9 and 12 months of age. The study also determined the difference of anemia between term and preterm infants. Methods: The subjects of this study were infants aged 9 to 12 months who visited outpatient clinics of Chung-Ang University Hospital from January 2006 to August 2018 for the purpose of infant health screening and immunizations. We divided the subjects as the term group and the preterm group, and their medical records were retrospectively analyzed. Results: One hundred and fifty-two infants were included in the study. There were 51 in the preterm infant group and 101 in the term infant group. Thirteen infants were diagnosed with iron deficiency anemia, and 12 infants of these infants were in the term group and one infant was in the preterm group, which was statistically significant (P<0.001). There are significant differences in the hemoglobin (12.0±1.1 g/dL, 12.6±1.2 g/dL), hematocrit (35.8%±2.7%, 36.7%±3.2%), serum iron (60.8±25.4 μg/dL, 73.5±40.9 μg/dL), and unsaturated iron binding capacity (279.1±67.7 μg/dL, 252.0±47.5 μg/dL) between the term infant group and the preterm infant group, respectively (P<0.05). Conclusion: Iron deficiency anemia was significantly more often diagnosed in term infants than that in preterm infants. Preterm infants may have a lower prevalence of iron deficiency anemia than do term infants because the preterm infants are taking iron supplements prophylactically. Therefore, iron deficiency anemia should be prevented in term infants, and it is important to confirm the presence of iron deficiency anemia by conducting blood tests during the first 9 to 12 months of life.
디펩타이드의 B16 악성흑색종세포에서 멜라닌 생성억제작용
남희승 ( Hee Seung Nam ),김은현 ( Eun-hyun Kim ),김수연 ( Su Yeon Kim ),이현이 ( Hyun-e Lee ),홍지연 ( Jiyun Hong ),이재국 ( Jae Guk Lee ),조성태 ( Sung Tai Cho ),조양환 ( Yang Hwan Cho ),윤혜영 ( Hye-young Yun ),백광진 ( Kwang Ji 대한화장품학회 2012 대한화장품학회지 Vol.38 No.1
본 연구에서는 B16 악성흑색종 세포에서 디펩타이드(dipeptide)의 멜라닌생성 저해 효과를 연구하였다. 실험결과 WV (트립토판-발린), WM (트립토판-메치오닌), CQ (시스테인-글루타민)는 멜라닌 생성을 농도 의존적으로 감소시켰다. 그러나 디펩타이드는 멜라닌 생합성과정의 속도 조절 단계 효소인 타이로시네이즈(tyrosinase)의 활성을 직접 감소시키지는 않았다. 따라서 타이로시네이즈의 발현양상을 조사하였고, 실험 결과 α-MSH가 유도한 타이로시네이즈 발현이 WV, WM, 그리고 CQ에 의해 억제되었다. 그러므로 WV, WM, 그리고 CQ가 타이로시네이즈의 억제성 조절(down-regulation)을 통해 멜라닌 생성을 감소시킨다고 제안될 수 있다. In the present study, we investigated the effects of dipeptides on melanogenesis in B16 melanoma cells. It was found that WV (Trp+Val), WM (Trp+Met), and CQ (Cys+Gln) decreased melanin production dosedependently. However, dipeptides did not directly inhibit tyrosinase activity, the rate-limiting melanogenic enzyme. Therefore, we further investigated the expression of tyrosinase. Our results showed that α-MSH-induced tyrosinase expression was down-regulated by WV, WM, and CQ. Thus, we propose that WV, WM, and CQ show hypopigmentary activity through tyrosinase down-regulation.