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조문균(Moon Kyun Cho),정승호(Seung Ho Jung),황규왕(Kyu Uang Whang),김영근(Young Keun Kim) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.2
We report a case of zosteriform cutaneous metastasis from choangiocarcinomasin a 56-year-old male patient who has asymptomatic and painless erythematous papules and scaly patches over the anterior side of his right upper abdomen along the back, Tendernatome level. Histopathologic examina.tions of the cutaneous lesion reveaed a tumor cell showing glandular structure and multifocal tumor emboli within dilated lymphalics. and a few signetring cells in the dermis. We found that the retrograde studies revealed cholangiocarcinom. after confirmation of zosteriform cutaneous metastasis. He died eight months after the appearance of zosteriform cutaneous metastasis. (Kor J Dermatol 1993; 31 (2): 280-284)
아토피피부염 환자에서 소아와 성인의 MAST CLA 검사에 의한 혈청 총 IgE 검사와 알레르겐 특이항체 검사 성적의 평가
김형동 ( Hyung Dong Kim ),조문균 ( Moon Kyun Cho ),이성열 ( Sung Yul Lee ),이종석 ( Jong Suk Lee ),박영립 ( Young Lip Park ),황규왕 ( Kyu Uang Whang ),황보영 ( Bo Young Hwang ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.5
Background: The multiple allergosorbent test chemiluminescent assay (MAST-CLA) system is a simple method for measuring total and allergen-specific IgE antibodies in the serum of patients with atopic dermatitis. Total IgE, however, is much frequently higher, even if no allergen-specific IgE antibodies can be detected in serum. Objective: The purpose of this study was to evaluate total IgE class, the allergen frequencies and their correlations in MAST-CLA in child and adult atopic dermatitis patients respectively. Methods: A total of fifty two adult patients and ninety child patients with atopic dermatitis were evaluated by MAST-CLA between march 2002 and march 2005 at Soonchunhyang hospital. Positive rates of specific IgE and the total serum IgE level of the MAST-CLA allergy system were compared between child and adult patients. Results: Among the subjects, 84.5% (80.0% for child patients and 92.3% for adult patients) of patients showed an elevated serum total IgE (more than class level 2) and 54.9% (45.6% for child patients, 71.2% for adult patients) revealed at least more than one allergen-specific IgE by MAST-CLA. The average 3.76 (3.39 for child patients, 4.16 for adult patients) different allergens was simultaneously detected in a single positive serum. Commonly-positive allergen rates, in descending order, were D. farinae 44.4%, D. pteronyssynos 38.7% and house dust 26.8%. Furthermore, the higher total serum IgE level in adult patients, the more probability of allergen-specific IgE positive results being disclosed (p<0.05). The number of allergen-specific IgE positive results was increased in a higher serum total IgE level (p<0.05). But total IgE positive rates which had allergen-specific antibody negative patients was 37.5% (45.8% for child patients, 25.0% for adult patients). Good correlation was obtained between total IgE levels and number of positive allergen-specific IgE in MAST-CLA, with 0.551 correlation coefficiency (p<0.05). Conclusion: Our study suggested that the MAST-CLA allergy system is a useful screening test to detect allergenspecific IgE and to evaluate patients with atopic dermatitis. But other allergen screening tests should be used for detecting allergens, when MAST-CLA total IgE class is increased over class 2 with no detectable specific IgE. (Korean J Dermatol 2007;45(5):413~421)
피부종양에서 HOX D3와 혈관성장인자(VEGF-C)의 발현
김형동 ( Hyung Dong Kim ),조문균 ( Moon Kyun Cho ),박영립 ( Young Lip Park ),이종석 ( Jong Suk Lee ),황규왕 ( Kyu Uang Whang ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.4
Background: The anatomical relation between a malignant tumor and its vascular and lymphatic bed is an important influencing metastasis. Hox D3 is required for these expressions of integrin αvβ3 and urokinase plasminogen activator (uPA), which contribute to endothelial cell adhesion, invasion, and migration during angiogenesis. Recent studies in different tumor types have shown that vascular endothelial growth factor-C (VEGF-C), which displays a high specificity for lymphatic endothelium, is involved in tumor-induced lymphagiogenesis and lymphatic metastatic spread. Objective: This study was designed to measure the expression of HOX D3 and VEGF-C in different skin cancers. Methods: The expression of HOX D3 and VEGF-C was examined by immunohistochemical staining of 40 skin cancer tissue samples, including 8 keratoacanthomas, 8 extramammary paget`s disease, 8 basal cell carcinomas, 8 squamous cell carcinomas and 8 malignant melanomas. Results: Immunohistochemical analysis of 40 skin cancer tissue samples revealed a high expression of HOX D3 and VEGF-C in the more aggressive and invasive skin tumors, including squamous cell carcinomas and malignant melanomas. On the other hand, low expression was seen in the less-invasive skin tumors, including keratoacanthomas, extramammary paget`s disease and basal cell carcinomas. Also the degree of expression of HOX D3 and VEGF-C showed a statistically-significant correlation with each skin tumor (p<0.05). Conclusion: These findings provide evidence that the upregulation of HOX D3 and VEGF-C might be involved in the promotion of angiogenesis and lymphagiogenesis in skin tumors and play an important role in metastasis. (Korean J Dermatol 2007;45(4):354~361)
다양한 피부 종양에서 c-Jun과 JunB 발현에 관한 연구
고범준 ( Bum Joon Ko ),조문균 ( Moon Kyun Cho ),박영립 ( Young Lip Park ),이종석 ( Jong Suk Lee ),이증훈 ( Jeung Hoon Lee ),황규왕 ( Kyu Uang Whang ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.4
Background: c-Jun along with JunB, JunD, and the Fos group proteins comprise the core members of the activatorprotein 1 (AP1) family of transcription factors. Recently, many studies have demonstrated the key roles of AP1 inregulating a wide spectrum of biological processes, including tumorigenesis. We therefore hypothesized that c-Junand JunB influence the differentiation and malignant change of various skin tumors. Objective: We measured the expression levels of c-Jun and JunB in different skin tumors. Methods: The expressions of c-Jun and JunB were examined by performing the immunohistochemical staining of 55specimens of skin tumors, including 13 cases of seborrheic keratosis, 4 cases of keratoacanthoma, 9 cases of actinickeratosis, 4 cases of Bowen’s disease, 4 cases of basal cell carcinoma, 16 cases of squamous cell carcinoma, and5 cases of malignant melanoma. Results: Immunohistochemical analysis of the skin tumor tissue samples revealed a significantly higher expressionof c-Jun in malignant skin tumors (basal cell carcinoma, squamous cell carcinoma, malignant melanoma) than inbenign (seborrheic keratosis, keratoacanthoma) or premalignant skin tumors (actinic keratosis, Bowen``s disease). Theexpression of JunB, however, was significantly lower in malignant skin tumors than in benign skin tumors. Conclusion: These findings showed that c-Jun has a positive association with skin malignancies, while JunB has anegative association with skin malignancies. The role of AP1 as key regulators of cell proliferation and epidermaltumor progression is suggested.
강주형 ( Joo Hyung Kang ),조문균 ( Moon Kyun Cho ),최보라 ( Bo Ra Choi ),황규왕 ( Kyu Yang Whang ),노영석 ( Young Suck ),이창우 ( Chang Woo Lee ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Background: Heat shock proteins (HSP), especially the HSP 70 family, may play certain roles in the immunophysiology of some skin diseases such as psoriasis, pemphigus, and lichen planus. HSPs generally induce down-regulation of the process of apoptosis that is considered to be one of the acantholysis-producing pathways in pemphigus. Objective: We planned to examine possible roles of HSPs 70/105 in the blistering process in pemphigus vulgaris (PV) and pemphigus foliaceus (PF), in connection with the detection results of apoptosis in local tissue specimens. Methods: Immunohistochemical stainings and Western blot analysis were performed for the detection and semiquantitation of HSPs 70/105 in skin specimens from lesional, nonlesional, and normal control sites. Hoechst 33342 staining was simultaneously carried out to examine features of apoptosis in lesional skin specimens. Results: The findings on expression of HSP were as follows. In PV, the expression of HSP 70 was minimum or negative; however, in PF, the expression was obvious and recognizable in lesional and perilesional normal skin. In contrast, HSP 105 was not detected in all cases of PV and PF. The features of apoptosis were evident at the lesional skin of all cases of pemphigus with acantholytic changes. Conclusion: PV and PF had different relative intensities of HSPs in lesional tissue stainings, especially in cases with HSP 70. This suggests that there may be subtle differences in the mechanisms causing acantholysis between PV and PF. (Korean J Dermatol 2008;46(8):1003~1010)
노병화 ( Byoung Hwa Roh ),황규왕 ( Kyu Uang Whang ),조문균 ( Moon Kyun Cho ),박영립 ( Young Lip Park ),이종석 ( Jong Suk Lee ),이창우 ( Chang Woo Lee ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.7
Background: Pemphigus vulgaris is an autoimmune bullous dermatoses of skin and mucosa characterized by loss of adhesion between keratinocytes, a process known as acantholysis. Apoptosis, programmed cell death, may participate in pathogenesis of intercellular detachment and loss of cell-matrix interaction. Objective: This study was designed to investigate the induction of apoptosis in the pemphigus lesional epidermis and to elucidate the mechanism of apoptosis induced by pemphigus sera. Methods: Hoechst 33342 staining was performed to determine the induction of apoptosis in the pemphigus lesional epidermis. In addition, we used HaCaT cells treated with pemphigus sera and analyzed the expression of caspase-3, caspase-8, caspase-9 and bcl-2, bcl-xL, bax, bak by the RT-PCR method. Results: In Hoechst 33342 staining, typical findings of apoptosis were observed in the pemphigus lesional epidermis showing acantholysis. RT-PCR showed the upregulation of caspase group (caspase-3, caspase-8, caspase-9), the downregulation of antiapoptotic bcl-2 family (bcl-2, bcl-xL) and the upregulation of proapoptotic bcl-2 family (bax, bak). Conclusion: These results suggest that apoptosis may be associated with acantholysis of pemphigus lesional epidermis and may play an important role in the pathogenesis of pemphigus. (Korean J Dermatol 2007;45(7):650∼658)