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연구논문 : 의약화학 ; 2,4,6-치환 피리딘 유도체의 합성, topoisomerase 1 억제능 및 구조-활성 관계 연구
조룡현 ( Long Xuan Zhao ),문윤수 ( Yoon Soo Moon ),알준바스넷 ( Arjun Basnet ),김은경 ( Eun Kyung Kim ),장영동 ( Yurng Dong Jahng ),박재규 ( Jae Gyu Park ),정태천 ( Tae Cheon Jeong ),조원제 ( Won Jea Cho ),최상운 ( Sang Un Choi ) 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-
연구논문 : 의약화학 ; COX 및 5-LOX에 대한 이중 억제 활성을 갖는 프로페논 모핵의 간단한 방향족 화합물의 합성
장영동 ( Yurng Dong Jahng ),조룡현 ( Long Xuan Zhao ),문윤수 ( Yoon Soo Moon ),알준바스넷 ( Arjun Basnet ),김은경 ( Eun Kyung Kim ),장현욱 ( Hyeun Wook Chang ),주혜경 ( Hye Kyung Ju ),정태천 ( Tae Cheon Jeong ),이응석 ( Eung Seok 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-
Synthesis, Characterization and in Vitro Identification of N^7-Guanine Adduct of 2-Bromopropane
Zhao, Long-Xuan,Kim, Eun-Kyung,Lim, Hyun-Tae,Moon, Yoon-Soo,Kim, Nam-Hee,Kim, Tae-Hyung,Choi, Heesung,Chae, Whigun,Jeong, Tae Cheon,Lee, Eung-Seok 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Recently, we have reported that 2-bromopropane might have an immunotoxic potential in rats when exposed for 28 days. In the present studies, the possibility of 2i-deoxyguanosine adduct formation by 2-bromopropane was investigated in vitro to elucidate molecular mechanism of 2-bromopropane-induced immunosuppression. N^7-Guanine adduct of 2'-bromopropane (i.e., N^7-isopropyl guanine) was chemically synthesized and structurally characlerized by analysis of UV, ^H-NMR, ^12C-NMR, COSY and fast atom bombardment, mass spectrometry to use as a reference material. Incubation of 2'-deoxyguanosine with an excess amount of 2-bromopropane in PBS buffer solution, pH 7.4, AT 37℃ for 16 h, followed by a thermal hydrolysis, produced a detectable amount of N^7-isopropyl guanine by an HPLC and UV analysis. The present results suggest that 2-bromopropane might form a DNA adduct in N^7 position of 2'-deoxyguanosine at a physiological condition.
Zhao, Long-Xuan,Kim, Tae Sung,Ahn, Soo-Hyun,Kim, Tae-Hyung,Kim, Eun-Kyung,Cho, Won-Jea,Choi, Heesung,Lee, Chong-Soon,Kim, Jung-Ae,Jeong, Tae Cheon,Chang, Ching-jer,Lee, Eung-Seok 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
For the development of new anticancer agents. 2.2':6'.2"-, 2.2':6'3"??and 2.2':6'4"-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity-Structuer-activity relationship studies indicated that 2.2':6'.2"-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2.2':6'.3"- and 2.2':6'.4"-terpyridine derivatives were potent topoisomerase I inhibitors.
Kim, Yong-chul,Zhao, Long-Xuan,Kim, Tae-Hyung,Je, Sun-mi,Kim, Eun-kyung,Choi, Heesung,Chae, Whi-Gun,Park, Minsoo,Choi, Jongwon,Jahng, Yurngdong,Lee, Eung-Seok 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
For the development of new anticonvulsive agents. r-vinyl GABA(vigabatrin) and GABA mimeties derivatives were covalently coupled as potential dual acting prodrugs and evaluated for their anticonvulsive activities. Among the prepared com-pounds. 11 showed the most potent anticonvulsive activity, a shorter onset time and a broader spectrum compared to vigabatrin. ⓒ 2000 Elsevier Science Ltd. All rights reserved.
DESIGN AND SYNTHESES OF 2-OXIRANECARBOXYLATE DERIVATIVES AND THEIR HYPOGLYCEMIC ACTIVITIES
Jew, Sang-sup,Kim, Eun-kyung,Je, Sun-mi,Zhao, Long-Xuan,Kim, Hyung-ook,Park, Hyeung-geun,Ko, Kwang-ho,Kim, Won-ki,Kim, Hwa-Jung,Cheong, Jae Hoon,Lee, Eung-Seok 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase Ⅰ(CPT-Ⅰ) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative(13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir(3).