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石菖蒲 추출물이 생쥐의 사회ㆍ심리적 스트레스에 미치는 영향
조수인,김형우,졍용식 대한본초학회 2004 大韓本草學會誌 Vol.19 No.4
Objectives : Stress is one of the deleterious factors for health, and many diseases are likely to be related to stress. The effects of Acorus Graminei Rhizoma extract were tested for the anti-sociopsychological stress action. Methods : 250g of dried Acorus Graminei Rhizoma was extracted(AGE) with pure water and the total extractive was evaporated under reduced pressure to give 39.7g. ICR male mice(20±2g) were fed orally with the dose of 100㎎/㎏/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Results : AGE administered group showed a significant decrease of serum corticosterone secretion compared with control group. Noradrenaline secretions in the dorsal cortex of brain showed no change. Lipid peroxidation of the liver and serum of mice were tested by measuring malondialdehyde, but AGE admistration showed no change. Conclusion : Above results suggest that AGE can rid the sociopsychological stress by decreasing serum corticosterone secretion.