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- 저자 : 정현철(Hyung Cheol Chung) (검색결과 2 건)
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진행암에서 Recombinant Human Interferon Alpha ( Rifn α ) 의 Phase 1 임상 및 약물동태에 관한 연구
노재경(Jae Kyung Roh),정현철(Hyun Cheol Chung),박용준(Yong Jun Park),김주항(Joo Hang Kim),김병수(Byung Soo Kim),현형환(Hyung Hwan Hyun) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A Fifteen patients with advanced cancers wre treated with recombinant interferon alpha (Alphaferon, Cheil Sugar Co.) by IM routes daily 5 times a week with the dose of either 3, 5, or 7´106 IU/m2 without intrapatient escalation in order to determine the tolerance and pharmacokinetics of IFN. Of the enrolled 15 patients, 12 patients were evaluable for toxicities and responses. Enrolled diseases were malignant melanoma (3), renal cell carcinoma (3), cutaneous T-cell lymphoma (3), non-small cell lung cancer (2), CML (1), breast cancer (1), stomach cancer (1), and fibrosarcoma (1). The median duration of treatment was 2 months. Of the evaluable 4 patients with the 3´105IU/m2 dose, a mild degree of flu-like syndrome in all, nausea and vomiting (severe; 1) in 3 and a mild degree of reversible elevation of hepatic transaminases was observed in 1 patient. Of the evaluable 6 patients with 5´106 IU/m2 dose, mild to moderate degree of flu-like syndrome in all, mild degree of reversible elevation of hepatic transaminases in 1, and mild degree of leukopenia in one patient was observed. Of the evaluable 3 patients with 7´108 IU/m2, severe flu-like syndrome in all, and moderate degree of leukopenia was observed in 2 patients which required dose modification. One patient with malignant melanoma showed partial response of the metastatic lymph nodes more than 12 months. Serum peak concentration of IFN was reached 4-8 hours after the IM treatment and the serum concentration was declined slowly to less than 10% of the peak concentration by 24 hours. The 24-hour urinary excretion of IFN was less than 1% of administered dose. Alphaferon was tolerable to the patients without life threatening toxicities, and the suggested MTD was 6×106 IU/m2/D with this dose schedule.
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김동립(Dong Lip Kim),정현철(Hyung Cheol Chung),노재경(Jae Kyung Roh),최진혁(Jin Hyuk Choi),박용준(Yong Jun Park),이화영(Wha Young Lee),김원호(Won Ho Kim),장준(Joon Chang),이상인(Sang In Lee),김승민(Seung Min Kim),서창옥(Chang Ok Suh 대한내과학회 1989 대한내과학회지 Vol.37 No.6
N/A We reviewed 10 cases of leptomentingeal car cinomatosis seen at the Yonsei Medical Center and Yonsei Cancer Canter from August 1987 to April 1989. The primary diseases of meningeal metastasis were stomach cancer (5 cases), lung cancer (3 cases) and breast cancer (1 cases). In one case, the primary site was not identified. Signs and symptoms were classified as involving the brain, cranial nerves, or spinal nerves. Most patients had symptoms or signs in more than one area. On initial spinal fluid examination of 7 patients, 4 patients had cytologic evidence of leptomeningeal metastasis. Repested spinal fluid assay yielded a positive cytology in anjother 2 patients. Eight patients were treated by intrathecal methotrexate administration and/or brain radiotherapy. Five of them experienced improvement or stabilization of neurologic sympoms; median survival was 40 days (27~45 days) after diagnosis. Median survival of the remaining 3 nonresponders was 17 days (15~18 days) after diagnosis. We concluded that active treatment of leptomentingeal carcinomatosis with intrathecal methotrexate and brain irradiation may increase the quality of life, and further-more, may prolong survival in some patients.
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