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3차 의료기관에서 Helicobacter pylori 제균의 성적 질환과 투여된 약제, 투여 기간에 따른 제균의 성적과 제균 후 재감염에 대한 조사
정우철 ( Woo Chul Chung ),조영석 ( Young Seok Cho ),정정조 ( Joeng Jo Jeong ),이인석 ( In Seok Lee ),김상우 ( Sang Woo Kim ),양진모 ( Jin Mo Yang ),최명규 ( Myung Gyu Choi ),정인식 ( In Sik Chung ),박두호 ( Doo Ho Park ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.1
Background/Aims: Controversies regarding the indications and regimens for the eradication of Helicobacter pylori (H. pylori) still exist. Failure rates have been reported to range from 5% to 10%. This study aimed to evaluate the efforts for the eradication of H. pylori of a tertiary clinic. We assessed the eradication rates according to the diseases, therapeutic regimens, and duration of therapy. In addition, we examined the effectiveness of secondary regimens in patients who failed to respond to primary regimens and the reinfection rate after a successful eradication. Methods: We investigated 389 patients with documented H. pylori infection between January 1996 and December 2001. Results: The overall eradication rate was 79.2%. There were no significant differences in the eradication rates according to the diseases and therapeutic regimens. However, there was a significant difference according to the duration of therapy. Proton pump inhibitor-based 10-day and 14-day regimens were superior to 7-day regimens. The eradication rate of secondary regimens in patients who failed to respond to primary regimens was 76.9%. The reinfection rate after a successful eradication was 4.4%. Conclusions: These results suggest that proton pump inhibitor-based triple regimens with 10 or 14 days of duration should be considered as primary H. pylori eradication therapy. (Korean J Gastroenterol 2003;41:1-8)