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      • KCI등재

        연잎 추출물을 함유한 화장품의 안정성 평가

        최선주(Sun Ju Choi),김소영(Soyoung Kim),정윤주(Yoonjoo Jeong),구창섭(Chang Sub Ku),하병집(Buungjhip Ha),채희정(Hee Jeong Chae) 한국생물공학회 2011 KSBB Journal Vol.26 No.1

        The stability of cream containing lotus leaf extract (LLE) was evaluated. Stability pH and viscosity were measured at 3 different temperatures (25℃, 45℃ and 65℃), and at room temperature under the sun light at 2 day intervals during 12 days. The cleansing cream and foam cleansing containing the extract did not show a significant pH change at the different temperatures. However, the pH of the cleansing cream and foam cleansing containing LLE slightly decreased at 25℃. They showed a high stability at temperature conditions (45℃ and 65℃) and under the sun light condition. The cleansing cream and foam cleansing containing LLE did not show a significant viscosity change at 25℃, but had a tendency of decrease at 45℃ and 65℃. There was no significant offflavor and discoloration as well as physical changes such as creaming and cohesion at 25-65℃ and under the sun light condition. And this LLE could be used as a stable functional cosmetic material.

      • KCI등재

        사과꽃잎 추출물의 용매 분획으로부터 기능성 소재의 탐색

        최선주(Sun Ju Choi),조은아(Eun-ah Cho),조은혜(Eunhye Cho),정윤주(Yoonjoo Jeong),구창섭(Chang Sub Ku),하병집(Byungjhip Ha),채희정(Hee Jeong Chae) 한국생물공학회 2011 KSBB Journal Vol.26 No.2

        Fractional solvent extraction by organic solvents such as hexane, chloroform, ethylacetate, and butanol was carried out using 70% ethanol extract of apple flower leaves. Biological activities including antioxidant, whitening, antimicrobial and anti-wrinkle activities were investigated and bio-active materials of the extracts were identified using GC/MSD. Among the tested solvent fractions, ethylacetate fraction showed the highest total polyphenol content (1218.94 μg/mL), and flavonoid (140 μg/mL). The DPPH radical scavenging activities was over 80% at a dry matterbased concentration of 200 μg/μL and SOD-like activity was over 90% at 50 μg/mL concentration in ethylacetate fraction that was slightly lower than of ascorbic aicd. Tyrosinase inhibition activity related to skin-whitening was over 60% by ethylacetate fraction of 100 μg/mL. As an anti-aging effect, elastase inhibitory activity was about 45% in ethylacetate fraction. Also, it showed a significantly antimicrobial activity against P. acenes. From GC/MSD analysis, a characteristic peak of high content in ethylacetate fraction was identified as kaempferol, which has been reported as a bioactive compound.

      • KCI등재

        나노리포좀을 이용한 astaxanthin의 안정화

        유지민(Jimin Yoo),김소영(Soyoung Kim),조은아(Eun-ah Cho),조은혜(Eunhye Cho),최선주(Sunju Choi),정윤주(Yoonjoo Jeong),하병집(Byungjhip Ha),채희정(Hee Jeong Chae) 한국생물공학회 2010 KSBB Journal Vol.25 No.2

        본 연구에서는 이중결합을 가진 불포화화합물로 제조나저장 시 열과 산화 (빛)에 의해 쉽게 파괴되어 활성이 감소하여 응용범위에 한계가 있는 아스타잔틴의 안정성 향상을 위하여 나노리포좀 제형기술을 이용하였다. 제형안정성 평가를 통하여 리포좀 제조조건 및 조성비를 확립하였고, 포접나노리포좀을 제조하여 포접전의 아스타잔틴과 안정성을 비교 검토하였다. 아스타잔틴을 포접하여 포접나노리포좀 제조 시포접전의 아스타잔틴에 비해 열에 대한 안정성이 2배 정도 향상되고, UV 안정성 또한 3배 향상된 것을 확인하였다. 이상의 결과로부터 아스타잔틴을 포접한 포접나노리포좀은 안정성이 우수한 기능성 원료로서 산업적으로 용도를 넓히고 부가가치를 더욱 향상시킬 수 있을 것으로 기대된다. Astaxanthin is an unsaturated compound with a double bond. So it is easily decayed by heat and oxidation (light) during its storage and processing of it. Nanoliposome formulation technology was utilized to improve the stability of astaxanthin. Nanoliposome preparation conditions were established and the stability of astaxanthin encapsulated nanoliposome and free astaxanthin was investigated. Thermal stability and UV-stability of astaxanthin encapsulated nanoliposome increased up to two times and tree times, respectively. Astaxanthin encapsulated nanoliposome could be used as a stable functional material for industrial purposes.

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