http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
정연구(Yeon Gu Chung),이해숙(Hae Sook Lee),이경애(Kyung Ae Lee),정옥(Ok Joung),오원근(Won Keun Oh),김광동(Kwang Dong Kim),임종석(Jong Seok Lim),문자영(Ja Young Moon),조용권(Yong Kweon Cho),박순희(Sue Nie Park),윤도영(Do Young Yoon) 대한약학회 2002 약학회지 Vol.46 No.6
Cervical cancer is one of the leading causes of female death from cancer worldwide with about 500,000 deaths per year, A strong association between certain human papilloma viruses (HPV type 16 and 18) and cervical cancer has been well known. An extract of Saururus chinensis, named as PE-46, has been used to investigate whether this agent has the ability of inhibiting the oncogenes E6 and E7 of HPV type 16, PE46 inhibited the proliferation of human cervical cancer cell lines in a dose response manner, PE46 also inhibited the in vitro binding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53. In addition, PE-46 inhibited the in vitro binding of E7 and Rb which is essential tumor suppressor for the control of cell cycle. The levels of MRNA for E6 and E7 were also decreased by PE-46. SiHa cells treated with PE46 induced GO/G1 arrest, resulting in inhibition of growth. Our study showed that the PE-46 can inhibit the cervical carcinomas via both inhibition of bindings between oncogenes and tumor suppressors, and inhibition of G1->S S transition. PE-46 inhibited the oncogenecity of E6 and E7 of HPV 16 type, thus could be used as a putative modulating agent for the treaoent of cervical Carcinomas caused by HPV.
원발성 폐 수막종과 지연성으로 발생된 뇌수막종 -증례보고-
정연구 ( Yeon Gu Chung ),양재영 ( Jae Young Yang ),최천식 ( Chun Sik Choi ),채승완 ( Seoung Wan Chae ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.1
Primary extracranial and extraspinal meningiomas are rare tumors that usually occur in the head and neck region, and few cases have been reported in the chest. In the described case, a complete central nervous system evaluation eliminated meningioma at other locations, and allowed a diagnosis of primary pulmonary meningioma. We describe a case of primary pulmonary meningioma(PPM) treated by excision. A complete central nervous system evaluation eliminated the possibility of multiple involvement. However, 9 years later meningioma developed in the brain. Solitary primary pulmonary meningioma is rare, and delayed onset brain meningioma is extremely rare. A search of the literature failed to reveal a similar case. Accordingly, this may be the first description of a primary pulmonary meningioma associated with the delayed development of brain meningioma.