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      • KCI등재

        법랑아 세포종의 병리학적 및 조직화학적 연구

        정세용(Sei Yong Chung),이의웅(Eui Wung Lee) 대한구강악안면외과학회 1987 대한구강악안면외과학회지 Vol.13 No.1

        The purpose of this study is to compare ameloblastoma with and without recurrence on pathological and histochemical findings. The author studies 25 cases of ameloblastomas obtained materials from the Dept. of Oral pathology, College of Dentistry, Yonsei University for the period of Jan. 1977 to Dec. 1986. 1. Of 25 cases, recurrent cases were 7 cases, among which 4 cases were treated by enucleation, 2 cases by curettage and 1 case by segmental resection. 2. 25 cases of ameloblastoma occurred at any age groups but the 2nd decade was the most commonly involved. The average age was 33.6 years. The ratio of male and female was 1.8 : 1 which has slight predilection for male, and it was 5 : 2 in recurrent cases. 3. The most favorate site of ameloblastoma was posterior region of mandible (19 cases) and the next was anterior region (4 cases). The anterior and posterior region of maxilla were also involved (1 case, each other). 4. The major sign and symptom was swelling. Pain and pus discharge were also noticed. As to the clinical duration, 14 cases (56%) were found within 1 year and 21 cases (84%) within 2 years. 5. Radiographically, unilocular pattern (13 cases, 54%) was the most common form and multilocular (9 cases) and soap bubble (3 cases) were also common forms. 6. Histopathologically, the main histologic pattern was plexiform pattern (12 cases, 48%). Follicular pattern (9 cases, 36%) and mixed pattern (4 cases, 16%) were also exhibited. In recurrent cases, the most common pattern was follicular pattern (5 cases) and the next common patterns were plexiform (1 case) and mixed (1 case). 7. Histopathologically, ameloblastomas originated from odontogenic cyst were 6 cases, of which 5 cases were originated from dentigerous cyst and 1 case from odontogenic keratocyst. 8. In histochemical findings, the ameloblastic epithelial islands were surrounded by basement membrane. And there were no differences about hyalinized materials and glycogen in tumor cells between ameloblastoma with and without recurrent cases.

      • KCI등재

        DMBA 유도 햄스터 협낭암에서 홍삼 및 TOCOPHEROL의 항암효과에 대한 면역조직화학적 연구

        정세용(Sei Yong Chung) 대한구강악안면외과학회 1992 대한구강악안면외과학회지 Vol.18 No.1

        This study was undertaken to observe the effects of red ginseng and tocopherol on 9, 10 - dimethyl - l, 2 - benzanthracene(DMBA) induced cancer of the buccal pouch in hamsters. In this study eighty male golden Syrian hamsters, weighing about 150~200gm, were used and divided into 4 groups: normal group(n=8) - untreated ; control group(n= 24) - DMBA painted ; experimental group I (n=24) - DMBA painted and red ginseng( 15mg/100gm) administered ; experimental group II (n=24) - DMBA painted and tocopherol (2units/100gm) administered. According to groups, the animals were sacrificed every 2 weeks for 15 weeks. Microscopic examination was done and BrdUrd labeling index was calculated after examination of DNA synthetizing cells(S - phase) according to immunohistochemical staining. Distribution of DNA contents of the cell cycle was also measured with flow cytornetry. Comparative results between the various groups are as follows : 1. According to histopathologic features, carcinoma in situ was observed at 11 weeks in the control group and at 13 weeks in the experimantal group I and II. Well differentiated carcinoma was seen at 13 weeks in the control group and at 15 weeks in the experimental group I and II but features in the experimental group I were relatively more severe than those of the experimental group II. 2. In the distribution of the bromodeoxyuridine(BrdUrd) labeled cells, which were compatible to the histological grading, the greatest incorporation of BrdUrd was seen in the cells of the basal layer within the normal epithelium. When dysplatic changes were observed, BrdUrd was more significant in the parabasal cells. However, in carcinoma in situ, BrdUrd showed a disorderly arrangement throughout the whole thickness of the tumor epithelium. 3. BrdUrd labeling index, which correlated with histological findings, has a remarkable significance in nistologic diagnosis of precancerous lesions and prediction of tumor activity. Flow cytometry may be used to evaluate clinical malignancies by detection of aneuploidy and could be used indirectly to predict the period of tumor formation by detecting the distribution of cells in the S - phase and G₂/M phase. 4. Although both red ginseng and tocopherol had inhibitory effects on the DMBA induced cancer of the buccal pouch in hamster, red ginseng seemed to have more inhibitory effect in dysplastic changes and tocopherol seemed to have a more inhibitory effect after expression in carcinoma in situ.

      • KCI등재

        Osteoperiosteal flap 을 이용한 내측접근법에 의한 장골 이식술

        박형식(Hyung Sik Park),김일현(Il Hyun Kim),정세용(Sei Yong Chung),조문건(Moon Keun Cho) 대한악안면성형재건외과학회 1987 Maxillofacial Plastic Reconstructive Surgery Vol.9 No.1

        The ilium is a widely used site for obtaining cortical and cancellous bone and marrow for use as autogenous donor material in reconstruction of the maxillofacial bony defects. Two limitations has been mentioned when the ilium is used as a donor site. One is the disturbances of cartilagenous growth centers of the iliac crest due to surgical trauma, and the other is the post-operative morbidity. This is a report of two cases of the iliac bone graft to minimize post-operative morbidity of the ilium by the modified medial approach using osteoperiosteal flap which designed by Grillon G Let al. The results are as follows; 1. The surgical procedure was simple and the operation time could be shortened by easy reflecting of medial periosteum without stripping of the periosteum on the abdominal muscles and the iliac crst. 2. The post-operative pain on the donor site was minimized and return to ambulatory status could be hastened by which the gluteal muscles and their bony origin were not disturbed at all and rigid bony fixation & rebuilding of the iliac crest were establishe.

      • KCI등재

        Basal cell nevus Syndrome - 증례보고

        이충국(Choong Kook Lee),김일현(Il Hyun Kim),정세용(Sei Yong Chung) 대한악안면성형재건외과학회 1987 Maxillofacial Plastic Reconstructive Surgery Vol.9 No.1

        This is a case of basal cell nevus syndrome in a 19-year male Korean male. Basal cell nevus syndrome encompasses 5 major areas of abnormalities including cutaneous, dental & osseous, ophthalmologic, neurologic and sexua1 abnormalities. He had several stigmata of the syndrome, and could be summarized as follows: 1. He displayed congenital hydrocephalus, calcification of falx cerebri, pits of hand, and multiple jaw cysts, so we diagnosed him a patient with basal cell nevus syndrome. 2. He must be followed up by close observation for high potentiality of occurrence of basal cell carcinoma with aging and high recurrence rate of multiple jaw cysts.

      • KCI등재

        양측성 악관절 강직증의 치험례

        차인호(In Ho Cha),한지훈(Ji Hoon Han),이정구(Jeong Gu Lee),이충국(Choong Kook Lee),권칠성(C. S. Gwon),오성섭(Seong Sub Oh),김일현(Il Hyun Kim),정세용(Sei Yong Chung) 대한악안면성형재건외과학회 1987 Maxillofacial Plastic Reconstructive Surgery Vol.9 No.1

        This is a case of bilateral bony ankylosis of temporomandibular joint with severe micrognathia corrected by use of metallic condylar prosthesis after ramal surgery and coronoidotomy and then body osteotomy with graft of Pyrost(R) and chin augmentation with Medpor(R). The Postoperative results were good functionally and esthetically.

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