http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
정성택 ( Sung Taik Chung ) 한국화학공학회 1972 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.10 No.2
Unusually high mass transfer rates are often observed in fluid-fluid contacting operations. This may, in part, be attributed to the turbulent motions in the bulk phases which are expected to bombard the interface. In many systems, however, the interface itself may become active as mass transfer proceeds and the induced convection activities will undoubtedly enhance significantly the interphase mass transport. The general aspects of this problem are discussed briefly.
정상 액체 크로마토그래피를 이용한 taxane 으로부터 taxol 의 분리
장경곤,노경호,정성택 ( Kyung Kon Chang,Kyung Ho Row,Sung Taik Chung ) 한국공업화학회 1997 공업화학 Vol.8 No.2
항암제로 탁월한 효능이 있는 taxol을 정상 액체 크로마토그래피를 이용하여 주목나무의 추출물에서 분리하였다. Taxol을 분리하기 위해 시료 주입량은 5μl에서 100μl로 변화시키고, 이동상 유속은 1ml/min로 고정하여 일정 용매법으로 실험을 하였다. 실험에 사용된 이동상은 헥산, 에탄올, 메탄올, 1-프로판올, 이소프로판올이었다. Taxol과 유사한 성질를 갖는 표준시료 cephalomannine, taxol, 10-deacetyltaxol의 혼합물에서 taxol을 분리하였다. Cephalomannine, taxol, 10-deacetyltaxol 혼합물의 분리 실험 결과로 taxol의 분리 최적 조건은 2성분계에서 헥산/에탄올의 부피 조성비가 96/4이며, 3성분계에서는 헥산/1-프로판올 /메탄올의 부피 조성비가 96/2/2이었다. 분리시간은 2성분계에서 80분인데 비해 3성분계에서는 50분으로 적은 용매를 사용하여 분리할 수 있었다. 위에서 얻는 실험조건으로 실제 주목나무의 추출물 1 μg에서 taxol를 분리할 수 있었다. Taxol which is recognized as a powerful anticancer reagent was extracted from yew extract and separated by NP-HPLC ( Normal-PhaseHigh Performance Liquid Chromatography). The experiments were performed in the isocratic mode with 5μl to 100μl injection volume and 1ml/min mobile phase flow rate. The major mobile phase was hexane and small amounts of ethanol, methanol, 1-propanol and isopropanol were added to change the retention behavior. Prior to a real sample, the artificial mixture of taxol, cephalomannine and 10-deacetyltaxol was tested. They are hard to be separated because of similar chemical structures. The experimental results showed that the proper composition of mobile phase for separating the three components was found 96% hexane and 4% ethanol(vol.%) or 96% hexane, 2% 1-propanol and 2% methanol(vol.%). Compared to the run time of 80 minutes for the binary system, the mixture was separated within 50 minutes with the less amount of mobile phase for the ternary system. Finally, lμg of taxol was separated from yew tree extracts under the optimum operating conditions.