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정규원(Kyu Won Chung),정환국(Whan Kook Chung),선희식(Hee Sik Sun),정인식(In Sik Chung),안병민(Byung Min Ahn),김승남(Seung Nam Kim),이여민(Yeo Min Lee),방춘상(Choon Sang Bang),강혜정(Hye Jung Kang),최명규(Myung Kyu Choi),이용각(Yong K 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3
Although there has not been a satisfactory treatment for esophageal variceal bleeding, recently clinicians take interests in endoscopic sclerotherapy. But several complications were also reported after endoscopic sclerotherapy. One of these was mesenteric venous thrombosis which developed more prevalently when the sclerotherapy used in combination of vasopressin infusion. We experienced one case of mesenteric venous thrombosis after esophageal sclerotherapy with vasopressin infusion for control of esophageal variceal bleeding.
만성 C형 간염과 간 세포 암에서의 Proliferating Cell Nuclear Antigen ( PCNA ) 의 발현에 관한 면역조직화학적 관찰
정규원(Kyu Won Chung),선희식(Hee Sik Sun),김부성(Boo Sung Kim),이창돈(Chang Don Lee),이영석(Young Suk Lee),최상욱(Sang wook Choi),양진모(Jin Mo Yang),이봉수(Bong Soo Lee),방충상(Choong Sang Bang),나종순(Jon Soon Na) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5
N/A Backgrounds/Aims: It has been reparted that pmliferating cell nuclear antigen(PCNA) wouM be related to proliferating cells, and thus the PCNA labelling index may provide useful information about the hepatecjte ngeaeration of chronic hepatitis and the biologic behavior of hepatocellular carcinoma(HCC). Tbe aims of this study were to investigate any carrelation between the PCNA labellmg index and distribution pattern of proliferating cells in chronie hepatitis C and HCC in Korea. Methods: We obtained biopsy specimens in 31 patients with chronic hepatitis C and 49 patients with HCC. Results: PCNA expession rate and PCNA labelling index were 70,9 %(22/31cases), 3.1 +- 0.4 % in ehtonic hepatitis C, 72,2 %(26/36cases), 4.1> 1.7% in noncancerous tissue of HCC, 94,4 %(34/35cases), 21.2 +- 4.6% in cancer tissue of HCC, respectively. Bxpression rate af PCNA was significandy higher in HCC than that of chronic hepatitis C and noncancerous portion of HCC cases. 22 patients(70.9%) of 31 patients with chronic heaptitis C were positive in PCNA immunohistochemical staining. Incidence of distribution of PCNA positive hepatocytes in the lobule was 100% in periportal area, 68.1 % in mi*dxanal area, 13.6% in pericentral area and 22.7 % in bile ductules, respectively. And 72.7 % in periportal area and midzonal area,4.5% in periportal area and pericetnal area, 13.6% in panlobular area.In patients with HCC, many PCNA positive tumor cells were seen thmughout the neoplasms. Conclusians: These results suggest that the proliferating a4tivities such as PCNA labelling index and PCNA expression pattern may represent the chronicity of chranic hepatitis C. (Kereaa J Gastroenterol )907;29:651-658)
과민성 대장염환자에서 이중 맹검 투여한 Tiropramide의 치료 효과
정규원(Kyu Won Chung),선희식(Hee Sik Sun),김부성(Boo Sung Kim),정인식(In Sik Chung),최명규(Myung Gyu Choi),최규용(Gyu Yong Choi),박수헌(Soo Heon Park),장창훈(Chang Hoon Jang),한준열(Jun Yeul Han) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A A double-blind, randomized parallel group trial comparison study was performed in 63 patients with irritable bowel syndrome for evaluation of effectiveness and safety of Tiropramide. Over a treatment period of 4 weeks, Tiropramide (300 mgjday) were administered in 32 patients and placebo in 31 patients with irritable howel syndrome. The degrecs of symptom scores for abdominal pain, belching, flatulence, diarrhea, abdominal discomfortnesi, inadequate defecation, borborygmi, etc were assessed every week by interview of pat:ient.s during the treatment. At the end of the four week. treatment, 78.2% of the treatment group with Tiropramide and 40.5% of placebo group were markedly improved their symptoms. The degrees of symptom scores for abdominal pain, inconiplete evacuation, borborygmi, flatulence, abdominal distension, and intensity of nausea showed significant improvement in the treatment group compared with placebo group in each week assessrnent. One patient with Tiropramide treatment and two patients of placebo group experiencecl aggravation of symptoms during treatment but no one had adverse reaction during treatment. These results suggest that Tiropramide is effective and safe for the treatment of irriitable bowel syndrome.
B 형 만성 활동성 간염에 대한 천연형 Interferon alpha 의 안정성 및 효과
정규원(Kyu Won Chung),선희식(Hee Sik Sun),김부성(Boo Sung Kim),박두호(Doo Ho Park),이창돈(Chang Don Lee),최상욱(Sang wook Choi),한남익(Nam Ik Han),정진우(Jin Wu Jeung) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2
N/A To evaluate the efficacy and safety of natural interferon alpha (Green Cross Co.) in ten patients with chronic active hepatitis (CAH) type B, a course of 12 weeks natural IFN-alpha was given three times weekly by subuctaneous injection at a dose of 3 million unit (MU) In ten patients with HBeAg positive CAH type B, DNA polymerase and aminotransferase activities were assessed and compared before, during and after natural IFN-alpha administration. We followed up at least for 12 to 24 months. The peripheral blood white cell (WBC), granulocyte and platelet count were also checked before and after therapy. The results were as follows: 1) During administration of natural interferon alpha, DNA polymerase activities were declined significantly within first week and sustained and negative conversion in 70% (7/10). After administration of interferon, DNA polymerase activities were rebounded and negative in only 30% (3/10) at 6 months therapy. 2) Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were decreased significantly from 6 and 12 weeks after therapy, respectively (p<0.05) though transient increament of just after therapy. 3) During follow up period, loss of HBe Ag was found in 5 cases (50%). Of these, seroconversion (Anti-Hbe) of HBe Ag was found in 3 cases (30%). In 2 out of these 3 cases, loss of anti-Hbe and reappearance of HBe Ag in 1case, and sustained increament of serum alanine aminotransferase (ALT) were observed in 1 case, which were revealed progressive liver changes despite loss of Hbe Ag and seroconversion (Anti-HBe) during follow up period. HBe Ag reappeared in 2 cases, which were not seroconversion (Anti-HBe). Namely, loss of HBe Ag and seroconversion (Anti-HBe) and normal serum transaminase were observed in 1 case (10%). 4) There was no significant clinical, hematological, biochemical changes after natural interferon alpha therapy. We concluded that subcutaneous injection of 3 MU natural interferon alpha was safe and effective in decreament of DNA polymerase and transaminase level transiently in patients with CAH type B. But long term therapy more than 3 months will be necessary for the eradication of Hbe antigenemia and clinical improvement for a long time, and repeated biopsy for the exact assessment of results.
흰쥐에서 총담관 폐쇄후의 간내담도에 대한 투과 전자 현미경적 관찰
정규원(Kyu Won Chung),김우중(Woo Joong Kim),이명석(Myung Seok Lee) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A Alteration of bile canalicular structure are known to occur in both intra-and extrahepatic cholestasis that develop in men as well as experimental animals. In order to evaluate the biochemical and ultrastructural characteristics of cholestasis in the liver of the rats, the authors conducted liver function test and examined the fine structural changes of intrahepatic biliary tract both in norrnal state and after 4 different time periods of comrnon bile ducts ligation with the transmission electron microscope. The serum SGPT began to rise irnmediately after the cornrnon bile duct ligation, showing highest value in the 24 hours group and the value decreased thereafter. The total bilirubin, total cholesterol, , r-GTP and alkaline phosphatase began to rise rapidly after the common bile duct ligation, showing highest values in the 1 week experimental group and the values decreased thereafter. After the common bile duct ligation, changes of the liver were most prominent in the bile canaliculi which showed typical structural alterations. There was the progressive dilatation of bile canaliculi with the loss of microvilli sometimes forming sacculation and diverticulation. Prominent ultrastructural changes of bile ductules after bile duct ligation were persistent bleb formations arid decreased number of rnicrovilli of luminal surface of ductular epithelial cells. The ductular epithelium showed atrophic changes and wideninp of intercellular space with abnormal microvilli was also observed.
Phalloidin 으로 유발되는 간세포막 변형에 대한 트립신 효과
정규원(Kyu Won Chung),이영석(Young Sok Lee),서정민(Jeong Min Suh),심규식(Kyu Sik Shim),양진모(Jin Mo Yang),안병민(Byung Min Ahn),김재광(Jae Kwang Kim),한남익(Nam Ik Han),김환묵(hwan Mook Kim),오구택(Goo Taeg Oh) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2
N/A Phalloidin, a bicyclic heptapeptide isolated from the mushroom Amanita phalloides, was reported as a membrane specific toxin inducing membrane protrusions in the isolated hepatocyte. The molecular basis of this injury most likely lies in the interaction of phalloirlin with the protein filaments of the plasma rnembrane. Trypsin was reported as one of the agents which preuent membrane protrusions of hepatocyte, from phalloidin. However, the exact mechanism of trypsin to the phalloidin action is still obscure. This study was designed to investigate the ultrastructures of isolated hepatoryte treated by phalloidin and trypsin, as a part of study to elucidate the mechanism of trypsin antagonisrn to phalloidin. In our experiments, multiple protrusions on the surface of isolated rat hepatocytes were observed, whereas trypsinized hepatocytes showed mild degree membrane protrusions along with hepatocyte aggregation after 20 min incubation with 10 ug/ml of phalloidin. The total number of aggregated cells were increased with gradual increase in trypsin concentration. These trypsin effects were disappeared spontaneously after twice washing of trypsinized heptocytes with Hank's balanced salt solution (HBSS) or treatment with soy bean trypsin inhibitor. Without trypsin, both Tween 80 trcated hepatocytes and hepatocyte ghosts were not aggregated but showed membrane protrusions with phalloidin. However, electron microscopy revealed mild membrane deformity on trypsin and phalloidin treated cells that was determined as normal under light microscopy. In conclusion, these results suggest that certain memmbrane structures in isolated rat liver cell, to which trypsin is reversely reartive, are required to recognze or to uptake phalloidin. These trypsin altered membrane structures lead to aggregation of hepatocytes upon reaction to phalloidin. And more studies should be performed to evaluate the mechanism of trypsin especially in regard to the hepatocyte aggregation.
정규원(Kyu Won Chung),선희식(Hee Sik Sun),심상인(Sang In Shim),강창석(Chang Suck Kang),박수헌(Soo Heon Park),한혁준(Hyeok Jun Han),노대근(Dae Keun Lo),박진노(Jin No Park),방춘상(Chun Sang Bang),최명규(Myong Gyu Choi) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.1
Hepatocellular carcinoma is one of the most common malignancies reported in ost of the Africa and South-east Asia. As hepatocellular carcinoma metastases well to distant site, half of the cases metastases to distant site at diagnosis. Hepatocellular carcinoma usually spread to regional lymph nodes around porta hepatis via lyphatics and venous metastasis can occur via intrahepatic vein. The usual sites of extrahepatic metastasis are lung, local lymph nodes, adrenal glands and bones, but epidural metastasis is very rare. Although the prognosis of the hepatocellular carcinoma was very poor in the past, the survival time seemed to be prolonged by early diagnosis and improvement of medical therapy. Therefore the importance of metastatic lesion of the hepatocellular carcinoma might be reemphasized. Recently we experienced a case of the hepatocellular carcinoma who developed paraplegia suddenly. MRI revealed ovoid epidural rnass at 6th and 7th dorsal vertebra level posteriorly. After emergency operation, the resected mass was confirmed metaststic hepatocellular carcinoma. (Korean J Gastroenterol 1997;30:119-125)
정규원(Kyu Won Chung),정환국(Whan Kook Chung),선희식(Hee Sik Sun),정인식(In Sik Chung),양진모(Jin Mo Yang),심상인(Sang In Shim),최명규(Myung Gyu Choi),양시영(Si Young Yang),김종률(Jong Yul Kim),이교영(Kyo Young Lee) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
Primary biliary cirrhosis (PBC) is a chronic inflammatory disease of unknown cause that is characterized by the destruction of small intrahepatic bile ducts. It is rare disease in Asia, especially in Korea. We report here a case of a 64-year old female with primary biliary cirrhosis and Sjogren s syndrome who has suffered from generalized pruritis and intermittent dry eye since 6 years ago, and sudden hematemesis. She was treated with endoscopic sclerotherapy, cholestyamine and ursodeoxy- cholic acid. We report the second case of primary biliary cirrhosis withe Sjogren's syndrome in Korea.
정규원(Kyu Won Chung),김부성(Boo Sung Kim),심규식(Kyu Sik Shim),양진모(Jin Mo Yang),안병민(Byung Min Ahn),이봉수(Bong Soo Lee),김진일(Jin Il Kim),김병욱(Byung Wook Kim),이영길(Young Gil Lee),황호원(Ho Won Hwang) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3
Fatal cases of mushroom poisonings are mostly caused by Amanita species in Korea. Arnanita mushrooms induce severe liver damage by cyclopeptide toxins which are thermostable. Human victims of acute Amanita poisoning usually undergo typical three phases. The gastrointesti nal symptoms of colicky abdominal pain, vomiting, watery diarrheaa begin 6-12 hr after ingestion of mushrooms. In most cases, gastrointestinal symptoms regress spontaneously and then clinical signs of severe hepatic injury develop. The histopathological findings of acute liver injuries are acute hemorrhagic necrosis of parenchyma, coagulative necrosis, vacuolated degeneration, micro-vesicular fat droplets, and yellow atrophy in the literature. However, the ultrastructural findings on human victim have been rarely reported. In Korea, total number of reported human victims of Amanita poisoing in the literature was belov 60 and there was no precise description on the subspecies of genus Amanita except only one in 1987. Recently, we experienced two cases of mushroom poisonings by Amanita virosa. Thus we report the clinical findings of the patients with the histological feature of liver injury using light and electron microscopy.