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전립선암에서 BRAF, KRAS 돌연변이 발현과 생존율과의 관계
성병주(Byung Ju Seong),정재민(Jae Min Chung),장희경(Hui Gyeong Jang),최성(Seong Choi) 대한비뇨기종양학회 2010 대한비뇨기종양학회지 Vol.8 No.1
Purpose: KRAS and BRAF are members of the MAP kinase (MAPK) pathway, which is hyperactive in approximately 30% of all cancers. We evaluated the mutational status of KRAS and BRAF in adenocarcinomas of the prostate. Materials and Methods: BRAF and KRAS mutations were characterized in 103 prostate adenocarcinomas using PCR/sequencing. The identified KRAS and BRAF mutations were analyzed via pre-treatment serum PSA, Gleason score, clinical tumor staging, and overall survival. Chi square testing, one-way ANOVA testing, and the Kaplan Meier method were used to perform association studies. Results: BRAF mutations were identified in 7 (6.8%) of 103 prostate adenocarcinomas. All mutations in codon 600 of the BRAF gene were Val600Glu (c.1799T>A) mutations. Mutations in codons 12 and 13 of KRAS were found in 30 (29.1%) of 103 prostate adenocarcinomas. All 30 KRAS mutations were Gly12Asp (c.35G>A) mutations. There was no concordant mutation of BRAF and KRAS in any single tumor specimen. Tumors with KRAS mutations, tumors with BRAF mutations, and tumors with neither mutation were no different statistically based on the Gleason score, clinical tumor stage, and pre-treatment serum PSA level. Prostate adenocarcinomas with BRAF mutations tended to be associated with lower overall survival than those with KRAS mutations and those with neither mutation (12.6 months vs. 32.2 months, 40.9 months, p=0.006). Conclusions: Prostate adenocarcinomas with BRAF mutations tended to be associated with a lower overall survival compared to those with KRAS mutations and those with neither mutation.
포스터 전시 : 췌담도 ; 대장암 의심병변의 수술후에 발견된 대장전이된 췌장암
김지연 ( Kim Ji Yeon ),김신 ( Kim Sin ),김유리 ( Kim Yu Li ),임대관 ( Im Dae Gwan ),김선정 ( Kim Seon Jeong ),유홍준 ( Yu Hong Jun ),박무인 ( Park Mu In ),박선자 ( Park Seon Ja ),장희경 ( Jang Hui Gyeong ),구자영 ( Gu Ja Yeong ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 췌장암은 후복막에 위치하여 임상증상이나 이학적 소견이 특징적이지 않아 조기진단이 매우 어렵고 진단당시 이미 주변장기로 전이되어 근치적 절제가 불가능한 경우가 많고,예후도 매우 나빠서 5년 생존율은 5% 미만이다. 특히 침윤성의 경향을 띄는 췌장암의 경우는 진단이 어렵고 다른 병으로 오인되는 수도 많으며, 진단시에는 이미 매우 진행된 예들이 많다. 우리는 최근 위와 대장에 전이되어 위의 scirrhous cancer로 오인되었던 췌장암 1예를 경