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바이오 물질 분석을 위한 금속 나노입자를 이용한 SERS 분석 연구동향
장의순(Eue-Soon Jang) 한국세라믹학회 2019 세라미스트 Vol.22 No.3
Surface enhanced Raman scattering (SERS) was first discovered in 1974 by an unexpected Raman signal increase from Pyridine adsorbed on rough Ag electrode surfaces by the M. Fleishmann group. 1) M. Moskovits group suggested that this phenomenon could be caused by surface plasmon resonance (SPR), which is a collective oscillation of free electrons at the surface of metal nanostructures by an external light source. 2-14) After about 40 years, the SERS study has attracted great attention as a biomolecule analysis technology, and more than 2500 new papers and 500 review papers related to SERS topic have been published each year in recently. 15) The advantages of biomaterials analysis using SERS are as follows; ① Molecular level analysis is possible based on unique fingerprint information of biomolecule, 16-20) ② There is no photo-bleaching effect of the Raman reporters, allowing long-term monitoring of biomaterials compared to fluorescence microscopy, ③ SERS peak bandwidth is approximately 10 to 100 times narrower than fluorescence emission from organic phosphor or quantum dot, resulting in higher analysis accuracy, 21), 22) ④ Single excitation wavelength allows analysis of various biomaterials, ⑤ By utilizing near-infrared (NIR) SERSactivated nanostructures and NIR excitation lasers, auto-fluorescence noise in the visible wavelength range can be avoided from in vivo experiment and light damage in living cells can be minimized compared to visible lasers, ⑥ The weak Raman signal of the water molecule makes it easy to analyze biomaterials in aqueous solutions. For this reason, SERS is attracting attention as a next-generation non-invasive medical diagnostic device as well as substance analysis. In this review, the principles of SERS and various biomaterial analysis principles using SERS analysis will be introduced through recent research papers.
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광촉매 활성이 우수한 판상형 ZnO 결정의 대용량 합성
김다정,김보미,조아라,심규동,한효원,노경현,장의순,Kim, Da-Jung,Kim, Bo-Mi,Joe, Ara,Shim, Kyu-Dong,Han, Hyo-Won,Noh, Gyung-Hyun,Jang, Eue-Soon 대한화학회 2015 대한화학회지 Vol.59 No.2
결정핵-매개 소프트-용액 방법을 이용하여 판상형 ZnO 나노입자를 합성하였다. 합성된 판상형 ZnO 나노입자는 많은 결함이 존재하는 (0001)면이 발달하여 상업적인 ZnO 나노입자 보다 광촉매 특성이 우수하였다. 또한, 판상형 ZnO 나노입자의 세포독성이 실리카 코팅을 통해 감소함을 확인하였다. 마지막으로 판상형 ZnO를 합성하는데 필요한 성장용액의 다양한 시약 조건들을 변화시키면서 상업적인 적용이 가능한 수백 그램 스케일로 대량합성 하는데 처음으로 성공하였다. ZnO nanoplates were prepared by seed-mediated soft-solution process. Photocatalytic property of ZnO nanoplates was superior to that of conventional ZnO nanoparticles owing to the enhanced (0001) plane with large defect sites. In addition, we found that silica coating method could provide to reduce cytotoxicity of ZnO nanoplates. Finally, we have successfully synthesized for the first time large-scale synthesis of plate-type ZnO as few hundreds gram scale for industrial applications through controlling various reagents of growth solution.
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이재열 ( Jae-yeul Lee ),김보미 ( Bo-mi Kim ),박세호 ( Se-ho Park ),최요한 ( Yo-han Choi ),심규동 ( Kyu-dong Shim ),문성배 ( Sung-bae Moon ),장의순 ( Eue-soon Jang ),양선아 ( Seun-ah Yang ),지광환 ( Kwang-hwan Jhee ) 대한화장품학회 2015 대한화장품학회지 Vol.41 No.1
나노입자의 응용은 1970년대부터 발전되어 왔다. 금속 나노입자에 빛을 조사하면 나노입자 표면에서 플라즈몬 공명(SPR, surface plasmon resonance)을 일으킨다. SPR 효과는 금속표면에 입사한 빛에너지에 의해 전자가 여기하며 공명을 일으켜 진동을 발생시키는 현상을 말한다. 여기 된 전자들이 금속원자들과 충돌을 일으키며 열에너지로 전환될 수 있는데 이를 금속의 광열효과(photothermal effect)라고 한다. 우리는 광열 효과를 이용하여 온열 화장품의 개발 가능성을 제시하고자 한다. 온열 화장품의 개발을 위해 생체 독성이 적은 금 나노입자를 선택하여 광열 효과에 있어서의 세포 생체적합성과 열효율을 살펴보았다. 금 나노입자의 합성 상태는 금 나노입자가 갖는 독특한 흡광 스펙트럼으로 확인하였으며, 금 나노입자의 농도는 원자 흡광분석기로 측정하였다. 세포의 독성평가는 MTT assay와 이중 염색법을 사용하였으며, 금 나노입자의 광열 효과는 제논 램프를 광원으로 하여 금 나노입자의 농도의 증가에 따른 광열 효과증대를 적외선-열화상 카메라로 확인하였다. 금 나노입자의 광열 효과를 온열 화장품에 적용한다면 한대 지방의 기후, 또는 겨울철에 태양 에너지를 열에너지로 전환시켜 피부에 손실된 열을 공급, 피부온도 유지에 도움이 되고 피부건강에 긍정적 효과를 주리라 사료된다. Many applications of nanoparticles have been developed since 1970s. Surface plasmon resonance (SPR) effect can be generated at the surface of nanoparticles by illumination. SPR is the resonant oscillation of conduction electrons at the surface material stimulated by incident light. The collisions between excited electrons and metal atoms can cause the production of thermal energy (photothermal effect). Here, we presented the development of thermo-cosmetics using photothermal effect of gold nanoparticles. Gold nanoparticles (GNPs) were chosen for it’s low toxicity. We also and investigated the cell biocompatibility and heating effectiveness for photothermal effect of GNPs. Synthesized GNPs were verified by UV-vis spectrophotometer, where GNP has a characteristic absorbance spectrum. Concentration of GNP was measured by atomic absorption analyzer. The cytotoxicity was confirmed by MTT assay and double staining assay. Photothermal effect of GNP was demonstrated by the thermal increasing properties depending on GNP concentration, which was taken by an IR-thermal camera with a xenon lamp as the light source. If the thermal effect of GNP is applied for thermo-cosmetics, it can supply heat to skin by converting solar energy into thermal energy. Thus, cosmetics contain ing GNPs can provide benefits to people in the cold region or winter season for maintaining skin temperature, which lead to a positive effect on skin health.
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