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최성원(Sungwon Choi),장옥진(Ok-Jin Jang),김양태(Yang-Tae Kim) 한국중독정신의학회 2014 중독정신의학 Vol.18 No.2
Objectives : The objectives of this study were to investigate intertemporal choice in patients with alcohol dependence and to examine whether impulsivity or working memory is related to intertemporal choice in patients with alcohol dependence. Methods : Fifty alcohol dependence patients and fifity healthy controls were recruited in this study. All participants were male. All patients were subjected to the following tests : Delay Discount-ing Task (DDT), the Wisconsin Card Sorting Test (WCST), the Barratt Impulsiveness Scale-11 (BIS-11), and the Korean version of Michigan Alcohol Screening Test (MAST-K). Results : Com-pared to the control group, the alcohol dependence group showed higher delayed reward discounting rate in DDT. The performance on the WCST of alcohol dependence group was significantly poorer than that of the control group. Alcohol dependence group scored higher than controls in the total score of the BIS-11 and the motor subscale scores. The perseverative error in WCST was significantly correlated with the 1 day indifference point (r=-0.505, p<0.01) and 2 day indifference point(r=-0.388,p<0.01) in DDT. However, the indifference point in DDT did not show significant relationships with the score of BIS-11 or MAST-K within the alcohol dependence group. Conclusion : Intertemporal choice in patients with alcohol dependence had more delayed reward discounting compared to the control group. Delayed discounting and impaired working memory were significantly correlated. Delayed discounting and self-report mea-sure of impulsivity or alcohol dependence were not correlated.
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생애초기스트레스와 불안정한 부모와의 유대관계가 의사결정유형과 음주동기에 미치는 영향
전재효(Jae-Hyo Jeon),장옥진(Og-Jin Jang),김기옥(Gi-Ok Kim),정영인(Young-In Chung) 한국중독정신의학회 2022 중독정신의학 Vol.26 No.1
Objective: The purpose of this study was to identify the effects of negative experience during childhood on drinking in adulthood. Methods: A total of 89 male subjects participated in the study and a survey was conducted July 1-July 31, 2019. Hierarchical regression analysis was conducted to confirm the relationships of early life stress (ELS) and insecure parental bonding (IPB) on decision-making style (DMS) and motivation for alcohol use (MA). Results: ELS and IPB had positive correlation with enhance and the coping subscore of MA. ELS and IPB had negative correlation with the rationality subscore of DMS and positive correlation with the intuition subscore of DMS. The regression analysis revealed ELS and IPB direct influence on enhance and coping among MA and rationality and intuition among DMS. These factors of DMS mediated the effects of ELS and IPB on enhance and coping of MA. Conclusion : This study found that early life stress and insecure parental bonding are related to irrationality and intuition among decision-making style and enhance and coping among motivation for alcohol use.
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만성적 정신분열병 또는 분열정동장애를 가진 입원환자에서 Aripiprazole와 Haloperidol의 치료효과 및 안정성 비교 : 16주간의 임상적 연구의 결과
서영익(Young-Ik Seo),김정기(Jeong-Gee Kim),장옥진(Ok-Jin Jang) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.2
1) 16주간 elozarpipira과 direpolah이을 사용한 군에서 나온 PANSS 점수를 보면 두 약물군 모두에서 효과를 보였다. 양성 증상에서는 두 군에서 차이를 보이지 않았으나 음성 증상, 일반 증상 그리고 총점에서는 모두 aripiprazole 군에서 더 나은 치료효과를 보였는데 이 중 음성 증상만이 통계적으로 의미있는 차이가 있었다. 2) 대사 증후군과 관련된 수치들을 살펴보면 체중, 허리둘레, 혈압에서는 두 군 사이에 차이가 없었으나 총 콜레스테롤에서는 aripiprazole 군이 haloperidol군에 비해 의미있는 감소를 보였으나 고밀도 콜레스테롤은 두 군 모두 감소하였다. 앞으로 만성 정신분열병 환자에서 대사증후군 발생에 대한 일관된 결과를 얻기 위해서는 좀 더 장기적인 연구와 관찰이 필요할 것으로 보인다. 3) 혈중 프로락틴의 경우 aripiprazole이 haloperidol에 비해 통계학적으로도 의미있는 감소를 보였다. Objectives: The authors compared the efficacy and safety between aripiprazole and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorder. Methods: This study was conducted in December, 2004 through April, 2007. We selected the subjects who were admitted to psychiatric clinic due to chronic schizophrenia or schizoaffective disorder as defined by DSM-Ⅳ criteria. The assessment of clinical symptoms was evaluated with PANSS before taking the drugs and every two weeks afterwards. The standard laboratory tests were also performed. The prolactin level was evaluated in every 4 weeks Results: Total of 72 subjects were assigned either aripiprazole(N=33) or haloperidol(N=39) according to the admission order. There were no statistically significant differences on demographic variables. After 16-week study was completed, there were no statistically significant differences in positive, general and total score in PANSS except negative symptom. There were no significant differences among the variables related to metabolic syn?drome except serum glucose and HDL cholesterol level between two groups. However, there was a significant difference in serum prolactin level. Conclusion: In the end, aripiprazole was generally good choice of treatment with less side effects, better tolerability than haloperidol. One, aripiprazole showed more improvements in negative, general and total PANSS subscales with no statistical significances except negative PANSS score. The other, the variables related to the metabolic syndrome need a further evaluation. And the last, aripiprazole yields more favorable serum prolactin level than haloperidol.
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