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장양숙(Yang Suk Jang),김재철(Jae Cheol Kim),류삼열(Sam Uel Ryu),박인규(In Kyu Park) 대한방사선종양학회 1989 Radiation Oncology Journal Vol.7 No.1
From Feb. 1985 to Feb. 1988, 76 patients with squamous cell carcinoma of the lung treated at the Department of Therapeutic Radiology in Kyungpook National University Hospital were available for the analysis of this study. All patients received radiation of 4000c0y-6600c0y with curative aim. The overall rate of complete response was 25.0% and partial response was 52.6%. The complete and partial regression of tumor was 14.3% in patients treated with dose below 5000 cGy and 84.1% in the group treated with dose above 5000 cGy (p<0.01). The complete response was seen only in the group of patients received radiation at least 6000 cGy. The patterns of failure were as follows. The rate of initial intrathoracic recurrence was 52.6% in patients with complete response. The overall rate of failure was 67.8%. Distant metastasis was found in 47.4% of patients. Bone, contralateral lung, and brain were common metastatic sites in decreasing order. All of the distant metastases and 80% of local recurrences were found within the first year after treatment.
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The Result of Combined Modality Treatment for Limited Stage Small Cell Lung Cancer
김재철,장양숙,류삼열,박인규,Kim Jae Cheol,Jang Yang Suk,Ryu Samuel,Park In Kyu The Korean Society for Radiation Oncology 1989 Radiation Oncology Journal Vol.7 No.2
1984년 7월부터 1988년 9월까지 경북대학교병원 치료방사선과에서 소세포 폐암으로 진단되어 복합화학요법 및 방사선 병용치료를 받은 27명을 대상으로 치료성적을 분석하였다. 완전관해율은 $70\%$, 부분관해율은 $22\%$, 무반응은 $8\%$였다. 여자, 수행상태 HO, 방사선량 4500cGy이상, 화학요법 4회 이상, 그리고 혈청 enolase수치 30ng/m1 이하 등에서 완전관해율이 높게 나타났으나 통계적 의의는 없었다. 중앙생존기간은 10개월이었고 1년생존율과 2년 생존율은 각각 $40.7\%$ 및 $12.2\%$였다. 생존율을 높이는 인자로는 수험상태 HO (p<005), 완전관해 (p<0.05), 하학요법 4회 이상(p<005), 방사선량 4500 cGy이상 등으로 나타났으며, 성별과 예방적 전뇌조사는 영향을 미치지 않았다. From July 1984 to September 1988, 27 patients with limited stage small cell lung cancer were treated with combined modality (combination chemotherapy Plus radiotherapy) at the Department of Therapeutic Radiology in Kyungpook National University Hospital. Of the 27 patients, 19$(70\%)$ achieved a complete response, 6$(22\%)$ a partial response, and 2$(8\%)$ no response. Female, performance status HO, serum enolase level below 30ng/ml, radiation dose over 4500 cGy, and 4 or more cycles of chemotherapy had a favorable effect on the rates of complete response, although there were no statistical differences according to the variables. Median survival time was 10 months and overall 1- and 2-year survival rates were $40,7\%$ and $12.2\%$, respectively. Complete response (p<0.05), performance status HO (p<0.05), 4 or more cycles of chemotherapy (p<0.05), and radiation dose over 4500 cGy had a significantly favorable effect on 2-year survival rate. Prophylactic cranial irradiation or sex had no effect on survival. The results of this study suggest that radiation treatment should be combined with combination chemotherapy in the therapeutic strategy of SCLC of limited stage.
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CT-based Radiation Therapy Treatment Planning in Lung Cancer
Ryu, Samuel,Jang, Yang Sug,Kim, Jae Cheol,U, Hong,Park, In Kyu 慶北大學校 醫科大學 1988 慶北醫大誌 Vol.29 No.3
1985년 3월부터 1987년 10월까지 경북대학교병원 치료방사선과에서 방사선치료를 받은 폐암 환자 90명을 대상으로 하여 재구성 전산화 단층영상을 이용한 방사선 치료계획의 유용성에 대해 분석하였다. 전산화 단층촬영술에 의한 방사선 치료계획으로 폐 등의 조직의 밀도를 정확히 교정할 수 있었고, 종양의 부위와 침윤 정도를 정확하게 파악할 수 있었으며, 방사선의 선량분포를 각 단면에서 영상 위에 직접 볼 수 있었을 뿐만 아니라 재구성영상을 통하여 3차원적으로 입체적 선량분포를 볼 수 있으므로 종양에는 관해에 충분한 방사선을 투여하면서 주위의 정상 조직에 가해지는 방사선을 최소화함으로써 폐암 환자의 치료 효과를 높일 수 있었음과 동시에 후유증을 방지할 수 있었다. Radiation treatment planning CT was very useful in ⑴ adequate lung correction, ⑵ accurate tumor localization, and ⑶ identification of reconstructive three-dimensional isodose distribution. Thus the local control of tumor could be promoted by delivering high radiation dose to the tumor tissue, while avoiding damage of the normal tissue.
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The Result of Combined Modelity Treatment for Limited Stage Small Cell Lung Cancer
김재철(Jae Cheol Kim),장양숙(Yang Suk Jang),류삼열(Samuel Ryu),박인규(In Kyu Park) 대한방사선종양학회 1989 Radiation Oncology Journal Vol.7 No.2
From July 1984 to September 1988, 27 patients with limited stage small cell lung cancer were treated with combined modality (combination chemotherapy plus radiotherapy) at the Department of Therapeutic Radiology in Kyungpook National Unviersity Hospital. Of the 27 patients, 19 (70%) achieved a complete response, 6 (22%) a partial response, and 2 (8%) no response. Female. performance status HO, serum enolase level below 30 ng/ml, radiation dose over 4500 cGy, and 4 or more cycles of chemotherapy had a favorable effect on the rates of complete response, although there were no statistical differences according to the variables. Median survival time was 10 months and overall 1-and 2-year survival rates were 40.7% and 12.2%, respectively. Complete response (p<0.05), performance status HO (p<0.05), 4 or mote cycles of chemotherapy (p<0.05), and radiation dose over 4500 cGy had a significantly favorable effect on 2-year survival rate. Prophylactic cranial irradiation or sex had no effect on survival. The results of this study suggest that radiation treatment should be combined with combination chemotherapy in the therapeutic strategy of SCLC of limited stage. 1984년 7월부터 1988년 9월까지 경북대학교병원 치료방사선과에서 소세포 폐암으로 진단되어 복합화학요법 및 방사선 병용치료를 받은 27명을 대상으로 치료성적을 분석하였다. 완전관해율은 70%, 부분관해율은 22%, 무반응은 8%였다. 여자, 수행상태 HO, 방사선량 4500cGy 이상, 화학요법 4회 이상, 그리고 혈청 enolase 수치 30ng/ml 이하 등에서 완전관해율이 높게 나타났으나 통계적 의의는 없었다. 중앙생존기간은 10개월이었고 1년생존율과 2년생존율은 각각 40.7% 및 12.2%였다. 생존율을 높이는 인자로는 수행상태 HO(p<0.05), 완전관해(p<0.05), 화학요법 4회 이상 (p<0.05), 방사선량 4500cGy이상 등으로 나타났으며, 성별과 예방적 전뇌조사는 영향을 미치지 않았다.
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