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장수찬 ( Suchan Chang ),김희영 ( Hee Young Kim ),양재하 ( Chae Ha Yang ) 대구한의대학교 제한동의학술원 2016 제한동의학술원논문집 Vol.14 No.1
OBJECTIVES : Acupuncture is a component of complex therapeutic and health care system of China that has been used for more than 2500 years. Although there are many hypothesis and experimental researches concerning acupuncture effects, the solid mechanisms underlying acupuncture effects remain poorly understood. The aim of this study was to review the literatures and reports related with various scientific theories about the acupuncture mechanism. And we hope that this review will contribute to an understanding of the acupuncture mechanisms. METHODS : We reviewedresearch articles in electronic databases such as RISS and Pubmed about the mechanism of acupuncture. RESULTS and CONCLUSION : This review summarized the following theories; (1) traditional acupuncture theory (Qi and meridian), (2) peripheral nerve theory, (3) connective tissue theory, and (4) Bong-Han theory (now called as Primo theory). Although their theories are supported by experimental evidence, there are many controversies and limitations to explain acupuncture effects fully.
혐오적 상황에 따른 쥐의 초음파 발성에 관한 문헌적 고찰
김다혜 ( Da Hye Kim ),장수찬 ( Suchan Chang ),이봉효 ( Bong-hyo Lee ),김희영 ( Hee Young Kim ) 대구한의대학교 제한동의학술원 2016 東西醫學 Vol.41 No.3
Objectives:Ultrasonic vocalizations (USVs) may present the emotional states in rats. Especially, 22kHz USVs have been elicited in negative emotion and aversive state. In this paper reviews previous studies concerned about the correlation between 22kHz Ultrasonic vocalization and various aversive states. Methods:We searched several previous literatures, research and review articles including keywords of ‘ultrasonic vocalization’ , ‘drug’ , ‘withdrawal’ or ‘pain’ in Pubmed and reviewed. Results and Conclusions: 1. In the 8 papers reviewed in this paper, recognized experimental rat produced 22-kHz USV calls in the followed 3 different aversive condition. 2. Rats produced 22-kHz USV calls in the withdrawal of drug, fear conditioning and chronic pain. The 22-kHz USV calls divided two different patterns which short and long 22-kHz USVs in the withdrawal of drug. Moreover rats appeared 22-kHz USV calls with the anxiety and depressive like behavior in the aversive condition.
자오정린,왕옌,린훵,후우후이,저우후우??,장수찬,한누리,정대화,양재하,김상찬,자오르옹지에,Zhao, ZhengLin,Wang, Yan,Lin, Feng,Fu, Hui,Zhou, FuBo,Chang, Suchan,Han, Nu Ri,Jung, Dae Hwa,Yang, Chae Ha,Kim, Sang Chan,Zhao, RongJie The Korean Medicine Society for the Herbal Formula 2014 大韓韓醫學方劑學會誌 Vol.22 No.1
Background and objective: Methamphetamine (Meth) is a widely abused psychostimulant that produces hyperlocomotion in rodents. Radix of Glycyrrhizae uralensis comprises a variety of bioactive components that have neuroprotective effects. In a previous study, we have demonstrated methanol extracts from radix of Glycyrrhizae uralensis (MEGR) suppress acute cocaine-induced extracellular dopamine release in the nucleus accumbens. In the present study, we investigated the effect of MEGR on acute Meth-induced hyperlocomotion. Methods: Male Sprague-Dawley rats were orally administered with MEGR (60 mg/kg and 180 mg/kg) 60 min prior to an intraperitoneal injection of Meth (1.0 mg/kg). Results: Behavioral analysis showed acute Meth greatly increased locomotor activities, while pretreatment with MEGR dose dependently inhibited the hyperlocomotion. In parallel, there were markedly increased levels of dopamine and its metabolite 3, 4-dihydroxyphenylacetic acid in the nucleus accumbens tissues in Meth-treated rats, which were also almost completely reversed by 180 mg/kg MEGR. Conclusions: These results showed that radix of Glycyrrhizae uralensis attenuates Meth-induced hyperlocomotion by inhibiting dopamine synthesis and utilization, suggesting that radix of Glycyrrhizae uralensis might be effective in blocking the rewarding effect of Meth.