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폐금속광산 지역 주민들의 요 중 비소종별 농도와 관련요인 평가
울 지(Ulziikhishig Surenbaatar),서정욱(Jeong-Wook Seo),김병권(Byoung-Gwon Kim),임현주(Hyoun-Ju Lim),장준영(Jun-Young Chang),이철우(Chul-Woo Lee),조성식(Seong-Sik Cho),손현진(Hyun-Jin Son),홍영습(Young-Seoub Hong) 한국환경보건학회 2020 한국환경보건학회지 Vol.46 No.6
Objectives: The purpose of this study was to evaluate urinary arsenic concentrations by arsenic species and to identify related factors among local residents near abandoned metal mines in Korea. Methods: Among the subjects of the Health Survey of Residents Near Abandoned Metal Mines for 2013-2017, 664 people were enrolled in this study. Urinary arsenic species analysis was performed using ICP/MS. Result: The geometric means (95% Confidence Interval) by urinary arsenic species were 0.15 (0.13-0.17) μg/ L for AsIII, 0.64 (0.55-0.75) μg/L for AsV, and 1.21 (1.05-1.40) μg/L for inorganic arsenic. The geometric means of urinary MMA and DMA were 1.58 (1.35-1.86) μg/L and 77.93 (72.61-83.63) μg/L, respectively, and that of organic arsenic was 83.15 (77.80-88.88) μg/L. The concentration of inorganic arsenic in the group using groundwater as drinking water was 1.36 (1.13-1.64) μg/L, which was statistically significantly higher than the 1.00 (0.80-1.25) μg/L in the other drinking water groups. Regarding rice consumption, the concentration of inorganic arsenic in urine in the group whose consumption was more than half rice produced in the residential area was 1.32 μg/L, which was statistically significantly higher than that of the 1.12 μg/L for the group whose consumption was less than half. Conclusion: In the analysis of the factors affecting the urinary inorganic arsenic concentration of the residents of the abandoned metal mine area, the use of groundwater as drinking water and consumption of rice produced in the residential area were considered related factors.
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흑연로 원자 흡광 광도기와 유도 결합 플라즈마 질량 분석기를
권정연(Jung-Yeon Kwon),김병권(Byoung-Gwon Kim),임현주(Hyoun-Ju Lim),서정욱(Jeong-Wook Seo),강민경(Min-Kyung Kang),김유미(Yu-Mi Kim),홍영습(Young-Seoub Hong) 한국환경보건학회 2018 한국환경보건학회지 Vol.44 No.5
Objectives: The aims of this study were to compare concentrations and the correspondence of human blood cadmium by using graphite furnace atomic absorption spectrometry (GF-AAS) and inductively coupled plasmamass spectrometry (ICP-MS), which are representative methods of heavy metal analysis. Methods: We randomly selected 79 people who agreed to participate in the research project. After confirming the linearity of the calibration curves for GF-AAS and ICP-MS, the concentrations of cadmium in a quality control standard material and blood samples were measured, and the correlation and the degree of agreement were compared. Results: The detection limit of ICP-MS (IDL: 0.000 µg/L, MDL: 0.06 µg/L) was lower than that of GF-AAS (IDL: 0.085 µg/L, MDL: 0.327 µg/L). The coefficient of variation of the quality control standard material showed stable values f or both ICP-MS (clinchek-1: 5.35%, clinchek-2: 6.22%) and GF-AAS (clinchek-1: 7.92%, clinchek-2: 5.22%). Recovery was relatively high for both ICP-MS (clinchek-1: 95.1%, clinchek-2: 92.8%) and GF-AAS (clinchek-1: 91.4%, clinchek-2: 98.8%), with more than 90%. The geometric mean, median, and percentile of blood samples were all similar. The agreement of the two instruments compared with the bias of the analytical values found that about 81% of the analytical values w ere within ± 30% of the deviation from the ideal reference line (y=0). As a result of the agreement limit, the value included in the confidence interval was about 94%, which shows high agreement. Conclusion: In this study, we confirmed there was no significant difference in concentrations of a quality control standard material and blood samples. Since ICP-MS showed lower concentrations than GF-AAS at concentrations below the method detection limit of GF-AAS, it is expected that more precise results will be obtained by analyzing blood cadmium with ICP-MS.
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폐금속광산 지역 주민의 비소 대사에 영향을 미치는 MTHFR , As3MT, GSTO1 유전자 다형성
울지(Ulziikhishig Surenbaatar),김병권(Byoung-Gwon Kim),손현진(Hyun-Jin Son),조성식(Seong-Sik Cho),김권민(Gwon-Min Kim),임현주(Hyoun-Ju Lim),권정연(Jung-Yeon Kwon),김기환(Ki-Hwan Kim),홍영습(Young-Seoub Hong) 한국환경보건학회 2021 한국환경보건학회지 Vol.47 No.6
Background: In South Korea, areas around abandoned metal mines are designated as regions with high arsenic (As) contamination. However, studies assessing urinary As exposure, As metabolism, and relevant genetic polymorphisms in residents of these metal mine areas are lacking. Objectives: To identify factors associated with As exposure and evaluate the effects of MTHFR , As3MT, and GSTO1 genetic polymorphisms on As metabolism in residents of abandoned metal mine areas by measuring urinary As species. Methods: Urinary As species (arsenite [As3+], arsenate [As5+], monomethyl arsonic acid, and dimethylarsinic acid) were isolated using high-performance liquid chromatography in combination with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Four genetic polymorphisms (MTHFR A222V, MTHFR E429A, GSTO1 A140D, As3MT M287T) were analyzed in 144 residents of four areas around abandoned metal mines. Results: The study sample was comprised of 34.7% men and 65.3% women, with a mean age of 70.7±10.9 years. The urinary inorganic As concentration was higher among those consuming more than half locally produced rice (0.31 μg/L) than those consuming less than half such rice (0.18 μg/L). The urinary dimethylarsinic acid concentration was higher in the group that had consumed seafood in the past day (31.68 μg/L) than in those who had not (22.37 μg/L). Furthermore, individuals heterozygous in the MTHFR A222V and GSTO1 A140D polymorphism had higher urinary arsenic species concentrations than did individuals with a wild type or homozygous for the variant allele. Conclusions: Consumption of locally produced rice was associated with inorganic As exposure, whereas seafood consumption was associated with organic As exposure among residents of abandoned metal mine areas. There was no clear association between MTHFR A222V and GSTO1 A140D polymorphisms and As metabolism.
ScienceON
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