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Atorvastatin이 주요 원인으로 추정되는 간 기능 장애에 대한 생간건비탕 가미방 치험 1례
권정연,김영지,박장경,공경환,고호연,Kwon, Jung-yeon,Kim, Young-ji,Park, Jang-kyung,Kong, Kyung-hwan,Go, Ho-yeon 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.5
Objective: A general prejudice exists that all herbal medicines are not good for liver. We report that herbal medicine can have positive effects on the liver, based on the improved liver function test levels observed in one patient. We also suggest the effectiveness of co-administration of herbal and western medicines. Methods: We checked the liver function test levels of one patient measured on 12 July at another hospital. We identified worse levels on 7 August, when he was first admitted to Semyung University Hospital. We measured liver function test levels of the same patient after treatment with Korean herbal medicine on 14 and 21 August during hospitalization at Semyung Hospital. We compared the figures and evaluated the effectiveness of 'Saenggangeonbi-tang' herbal medicine in the liver. Results: The patient's liver function test levels were normal on 12 July, but had become abnormal by 7 August, when he was admitted to Semyung Hospital. The cause of liver dysfunction was suggested as Atorvastatin, one of the western drugs he had started to take. Continuous treatment with Korean herbal medicine resulted in a definite improvement in liver function. Conclusion: Korean herbal medicine can provide positive improvements in liver function test levels.
흑연로 원자 흡광 광도기와 유도 결합 플라즈마 질량 분석기를
권정연(Jung-Yeon Kwon),김병권(Byoung-Gwon Kim),임현주(Hyoun-Ju Lim),서정욱(Jeong-Wook Seo),강민경(Min-Kyung Kang),김유미(Yu-Mi Kim),홍영습(Young-Seoub Hong) 한국환경보건학회 2018 한국환경보건학회지 Vol.44 No.5
Objectives: The aims of this study were to compare concentrations and the correspondence of human blood cadmium by using graphite furnace atomic absorption spectrometry (GF-AAS) and inductively coupled plasmamass spectrometry (ICP-MS), which are representative methods of heavy metal analysis. Methods: We randomly selected 79 people who agreed to participate in the research project. After confirming the linearity of the calibration curves for GF-AAS and ICP-MS, the concentrations of cadmium in a quality control standard material and blood samples were measured, and the correlation and the degree of agreement were compared. Results: The detection limit of ICP-MS (IDL: 0.000 µg/L, MDL: 0.06 µg/L) was lower than that of GF-AAS (IDL: 0.085 µg/L, MDL: 0.327 µg/L). The coefficient of variation of the quality control standard material showed stable values f or both ICP-MS (clinchek-1: 5.35%, clinchek-2: 6.22%) and GF-AAS (clinchek-1: 7.92%, clinchek-2: 5.22%). Recovery was relatively high for both ICP-MS (clinchek-1: 95.1%, clinchek-2: 92.8%) and GF-AAS (clinchek-1: 91.4%, clinchek-2: 98.8%), with more than 90%. The geometric mean, median, and percentile of blood samples were all similar. The agreement of the two instruments compared with the bias of the analytical values found that about 81% of the analytical values w ere within ± 30% of the deviation from the ideal reference line (y=0). As a result of the agreement limit, the value included in the confidence interval was about 94%, which shows high agreement. Conclusion: In this study, we confirmed there was no significant difference in concentrations of a quality control standard material and blood samples. Since ICP-MS showed lower concentrations than GF-AAS at concentrations below the method detection limit of GF-AAS, it is expected that more precise results will be obtained by analyzing blood cadmium with ICP-MS.
김영지,권정연,고호연,공경환,Kim, Young-ji,Kwon, Jung-yeon,Go, Ho-yeon,Kong, Kyung-hwan 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.5
Adrenal insufficiency is caused by adrenal failure or impairment of the hypothalamic-pituitary-adrenal axis. The main symptoms of adrenal insufficiency are chronic fatigue, nausea, vomiting, anorexia, and weight loss. We report a case of adrenal insufficiency in a 38-year-old female. The patient complained of headache, dizziness, anorexia, and general weakness. We treated her with Iggisaengjin-tang and acupuncture. After treatment, the patient's symptoms were improved and serum cortisol levels rose to a normal range without the aid of steroid supplementation therapy. This case suggests that Korean medicine can be effective in the treatment of adrenal insufficiency, but more clinical reports are needed.
김경배(Kim Gyoung Bae),권구인(Kwon Gu In),오염덕(Oh Ryum Duck),김평중(Kim, Phyoung Jung),정연만(Jeong Yeon Man),조동욱(Cho Dong Uk) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2
최근 태풍, 집중호우, 폭염, 전염병, 산불, 화학물 폭발‧누출사고 등에 의한 초대형 재난 발생빈도가 증가하고 있으며 피해 규모도 대형화 되고 있어 재난의 요인을 분석하고 효과적으로 대처하기 위한 노력이 필요하다. 본 논문에서는 소방청 및 관련 기관 등에서 소방재난안전 및 소방산업과 관련되어 생산·유통되는 대용량의 다양한 데이터를 센터를 통하여 수집‧정제한 후, 빅데이터 플랫폼을 이용 저장, 처리, 분석, 시각화를 통하여 소방산업 업체, 종사자, 관‧연‧학계 및 대국민에게 양질의 특화된 소방재난안전 및 소방산업분야 빅데이터 서비스 제공할 수 있는 소방안전 플랫폼을 구축하였다. 본 소방안전 빅데이터 플랫폼 및 센터 구축은 소방재난 분야 빅데이터 플랫폼 및 네트워크 구축을 통해 소방재난 및 소방산업 데이터의 축적‧유통을 활성화하고, 소방 데이터의 유통 및 거래 기반을 마련할 것이다.
폐금속광산 지역 주민의 비소 대사에 영향을 미치는 MTHFR , As3MT, GSTO1 유전자 다형성
울지(Ulziikhishig Surenbaatar),김병권(Byoung-Gwon Kim),손현진(Hyun-Jin Son),조성식(Seong-Sik Cho),김권민(Gwon-Min Kim),임현주(Hyoun-Ju Lim),권정연(Jung-Yeon Kwon),김기환(Ki-Hwan Kim),홍영습(Young-Seoub Hong) 한국환경보건학회 2021 한국환경보건학회지 Vol.47 No.6
Background: In South Korea, areas around abandoned metal mines are designated as regions with high arsenic (As) contamination. However, studies assessing urinary As exposure, As metabolism, and relevant genetic polymorphisms in residents of these metal mine areas are lacking. Objectives: To identify factors associated with As exposure and evaluate the effects of MTHFR , As3MT, and GSTO1 genetic polymorphisms on As metabolism in residents of abandoned metal mine areas by measuring urinary As species. Methods: Urinary As species (arsenite [As3+], arsenate [As5+], monomethyl arsonic acid, and dimethylarsinic acid) were isolated using high-performance liquid chromatography in combination with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Four genetic polymorphisms (MTHFR A222V, MTHFR E429A, GSTO1 A140D, As3MT M287T) were analyzed in 144 residents of four areas around abandoned metal mines. Results: The study sample was comprised of 34.7% men and 65.3% women, with a mean age of 70.7±10.9 years. The urinary inorganic As concentration was higher among those consuming more than half locally produced rice (0.31 μg/L) than those consuming less than half such rice (0.18 μg/L). The urinary dimethylarsinic acid concentration was higher in the group that had consumed seafood in the past day (31.68 μg/L) than in those who had not (22.37 μg/L). Furthermore, individuals heterozygous in the MTHFR A222V and GSTO1 A140D polymorphism had higher urinary arsenic species concentrations than did individuals with a wild type or homozygous for the variant allele. Conclusions: Consumption of locally produced rice was associated with inorganic As exposure, whereas seafood consumption was associated with organic As exposure among residents of abandoned metal mine areas. There was no clear association between MTHFR A222V and GSTO1 A140D polymorphisms and As metabolism.