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Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
임채진,이용문,강승구,Hyung W. Lim,신경오,정세규,허양훈,최수인,고명호,서호성,박병덕,박기돈,안정근,Yoshikazu Uchida,박경호 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by SA-β-gal staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.
임채진(Lim, Che-Zinn),추성원(Choo,Sung-Won),박무호(Park, Moo-Ho) 한국실내디자인학회 2011 한국실내디자인학회논문집 Vol.20 No.4
This study analyzed visitors’ behaviors in the viewpoint of Attraction Power and Holding Power of exhibits on the basis of exhibition layout of real science museums. Through the analysis, the study grasped efficiency of analysis index and exhibition environment elements which might have an effect on planning the exhibition space of a large-scale museum and producing detailed ranges of exhibition. The main indicators used are: 1. Attraction Power: it indicates the relative incidence of people who have stopped in front of an object/exhibit during the exhibition tour. It is calculated by dividing the number of people who stop by the total number of people who have visited the museum or gallery. 2. Holding Power: it measures the average time spent in front of an information/communication element. It is calculated by dividing the average time of stay by the time “necessary” to read an element. As a result of analyzing the exhibition areas of National Science Museum (Daejeon) and National Museum of Emerging Science and Innovation(Tokyo), the Holding Power was found to be relatively lower than the Attracting Power. This means that 3.5 out of 10 visitors stop in front of the exhibit in 6 exhibition areas, and among these, only 1/10 is used when compared to the user required time of the exhibits. In other words, like the method of deriving an analysis index, the stage of viewing can be categorized as Attracting Power and Holding Power, and because the stage from Attracting Power to the stage of Holding Power are strongly linked, it shows that it is not easy to display a meaningful result. Except, the general distribution of Attracting Power was shown to be high from the entrance area of the exhibition hall based on the standard of viewing sequence. Also, the Holding Power became sequentially lower according to the sequence of exhibition viewing and displayed a meaningful interrelationship with the distribution ratio of island exhibits. In the case of island exhibition method, it is less influenced by the movement flow of visitors when compared to the wall type method of exhibition and can be understood as an exhibition method that provides spatial chances enabling stopping and viewing.
관람객의 인지범위를 고려한 전시공간 분석 방법에 관한 연구
임채진(Lim, Che-Zinn),곽혜진(Kwak, Hye-Jin),윤성규(Yoon, Sung-Kyu) 대한건축학회 2013 대한건축학회논문집 Vol.29 No.8
At the exhibition space of open plan, it is vague to set the standard to separate the exhibition space. Because of that, there has been lots of difficulties on the quantitative analysis of the open plan exhibition areas. This study was to research and suggest the separating method of the exhibition space based on the exhibit using Voronoi polygon which is a mathematical / geometric concept. The position of cells is decided by applying the viewing distance from the exhibit regarding the exhibit in the existing exhibition space as coordinates. Targeting Gwacheon National Science Museum where is composed with exhibition space of open plan and various exhibits, this study tried to analyze the exhibition space applying Voronoi polygon. The space that required through the Voronoi diagram was applied to the block space analysis which was the phase analysis of the space syntax. Through this way, this study induced the result of the quantitative analysis at the open plan exhibition space. Through these methods, it seeks the availability on the methodology of this study.
미술관 전시공간의 벽구성에 의한 단위공간의 영역성과 가시성
임채진(Lim, Che-Zinn),박무호(Park, Moo-Ho) 대한건축학회 2011 대한건축학회논문집 Vol.27 No.10
This study aims at figuring out the characteristics of walls in the gallery exhibition space, and analyzing its territoriality and visibility to apply to exhibition space planning and to understand its meaning. The museum has been developed and changed variety by a social change and extension of its concept and social role. It might say that the relationship of unit space seems to be analyzed on the basis of floor plan, and is particularly determined by the wall structure. The wall restricts and divides space and also connects to other space through the gate. Accordingly, one unit space can be explained as territoriality restricted by the wall, and visibility connected by the gate. Through the analysis of four art museums, it proved that the characteristic wall structure of the gallery played an important and direct role in forming the flat shape of exhibition space and the structure of visual perception.