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실험연구 : 백서의 일과성 척수 허혈에서 저체온하 경막내 Bupivacaine의 효과
이정락 ( Jeong Rak Lee ),임정길 ( Jeong Gil Leem ),황승준 ( Seung Jun Hwang ),장동민 ( Dong Min Jang ),김정원 ( Jung Won Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.2
Background: Local anesthetics can reduece excitotoxic neuronal injury from ischemia. We investigated neuroprotective effects of intrathecally administered bupivacaine and hypothermia in rat model of transient spinal cord ischemia. Methods: A PE-l0 intrathecal catheter was implanted into thirty six male Sprague-Dawley rats through L4-5 interlaminar space. Animals of normothermia (N) and hypothermia (H) groups were administered 15 μl of normal saline, and 15 μl of 0.5% bupivacaine for bupivacaine (B) and bupivacaine-hypothermia (BH) groups. Transient spinal cord ischemia was induced by inflation of a 2 F Fogarty catheter placed into aortic arch for 12 minutes. During ischemia, rectal temperature was maintained to 37.0 ± 0.5℃ for N and B groups, 34.5 ± 0.5℃ for H and BH groups. Motor and sensory deficit score were assessed 2 and 24 hour after reperfusion. Lumbar spinal cords were harvested for histopathology, and for immunoreactivity of heat shock protein 70 (HSP70). Results: The motor and sensory deficit score of N and B group was significantly higher than H group (P < 0.05) and BH group (P < 0.05). There were also significant difference in the motor and sensory deficit score between Hand BH group at 24 hr (P < 0.05). Neuronal cell death and immunoreactivity of HSP70 was frequently observed in the N and B groups, but not in the H and BH groups. Conclusions: These results suggest that intrathecal bupivacaine did not provide neuroprotection during normothermic transient spinal cord ischemia in rats, but it can enhance neuroprotective effects of hypothermia. (Korean J Anesthesiol 2006; 51: 207~15)