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한우 종모우의 지방괴사증에 대한 Isoprothiolane 투여효과
이성수,임연수,정준,장윤호,박종관,박노형,원유석,김상근,Lee, Seoung-soo,Lim, Yeoun-su,Jeong, Joon,Jang, Yun-ho,Park, Jong-kwan,Park, No-hyoung,Won, You-seog,Kim, Sang-keun 대한수의학회 1999 大韓獸醫學會誌 Vol.39 No.3
The effect of isoprothiolane(di-isopropyl-1,3-dithiolan-2-ylidenemalonate) aganist fat necrosis in Hanwoo(Korean Cattle) sire was evaluated. The 10 heads of Hanwoo sire suffering from fat necrosis were given 50mg/kg body weight of isoprothiolane(0.2g/kg of Fujix, Japan) orally once a day for 8 weeks. In 30% of these, the size of the necrotic fat masses had decreased significantly 7 months after the adminstration. Isoprothiolane did not affect on live body weight and semen characteristics. However the sire affected with fat necrosis had higher MCHC(Mean corpuscular hemoglobin concentration) than normal sire in hematologic values 10 weeks after administration. Number of RBC(red blood cell) and PCV(packed cell volume) 10 weeks after administration had been increased than those before administration(p < 0.05). The serum concentrations of creatinine, triglyceride, and total cholesterol 10 weeks after administration were higher than those before administration while the concentration of glucose was vice versa. The isoprothiolane may reduce the oxidation of glucose, increase the glucose transfer to lipids, and increase blood supply to necrotic masses. These results indicate that isoprothiolane may be useful as the therapeutic agent aganist fat necrosis.
약물과 생체고분자간의 상호작용 Ⅹ : Difference Spectra 에 의한 Nalidixic acid , Probenecid 단백간의 결합에 관한 연구
김종국(Chong - Kook Kim),임연수(Yun - Su Lim),최준식(Jun - Shik Choi) 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.1
Binding of nalidixic acid which is used primarily in the treatment of urinary infection, and probenecid which is used as a uricosuric agent was studied using difference spectroscopy method. 2-(4`-hydroxybenzeneazo) benzoic acid is a spectrophotometric probe which shows absorption spectrum changes upon binding to protein. Difference absorption spectra of this probe were used as an indirect measurement of the binding of nalidixic acid and probenecid to bovine serum albumin. The results obtained using the spectrophotometric probe indicated that the numbers of the binding sites of two drugs were 2, and the association constants at 20℃ of nalidixic acid and probenecid were 1.07 × 10⁴ M^(-1) and 1.17 ×10⁴ M^(-1), respectiively.
김종국(Chong -Kook Kim),원용한(Young Han Won),양지선(Ji Sun Yang),임연수(Yun Su Lim),안혜영(Hae Young Ahn) 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.1
Binding of ibuprofenlysine with bovine serum albumin was studied and compared by fluorescence quenching method, difference spectroscopy and circular dichroism. These spectrophotometric methods are indirect measurements which need the probes. So 1-anilinonaphthalene-8-sulfonate was used as a fluorescence spectra probe, 2-(4` hydroxybenzeneazo) benzoic acid as a difference spectrophotometric probe, and sulfaethidole was used as a circular dichroism probe. The results by above three methods were compared and discussed.
김종국,임연수,양지선,정은주 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.3
To investigate the protein binding characteristics of cephalothin, the effects of ionic strength, pH and temperature on the binding of cephalothin to bovine serum albumin (BSA) were studied by UV difference spectrophotometric method. With increasing ionic strength at constant pH and temperature, association constant decreased, but the number of binding sites was about 2 constantly. It may be deduced that the binding process is not only due to electrostatic forces. And the increased association constant at high ionic strength is explained by conformational changes of BSA from complex to subunits. The pH effect on the affinity of interaction indicated that the binding affinity of drug is higher in the neutral region than in the alkaline region. And, at high pH value, the number of binding sites decreased from 2 to 1 because of the conformational changes of BSA in alkaline region. The decrease in binding affinity of BSA to drug with increasing temperature was characteristic of an exothermic reaction. And the negative sign of △G° meant that the binding process occurs spontaneously under the experimental conditions. In cephalothin-BSA complex formation, since the net enthalpy change value and entropy change value are positive, it is assumed that hydrophobic bindings are predominant in this binding process.