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만성폐질환에서 haemophilus influenzae 의 분리 및 약제 감수성에 관한 연구
김성규(Sung Kyu Kim),조철호(Chul Ho Cho),장상호(Sang Ho Jang),장준(Joon Chang),임명기(Myung Gi Lim),이원영(Won Young Lee),정윤섭(Jun Sop Chong) 대한내과학회 1990 대한내과학회지 Vol.39 No.3
N/A Hemophilus influenzae is being recognized with increasing frequenzy in various literature as a cause of pneumonia and of acute exacerbations of chronic lung disease indluding COPD and bronchiectasis. Currently, however, the incidence of H. influenzae ae a respiratory pathogen in adults is often underestimated in our country, In this study, the prevalence of H. iefluenzae and the antimicrobial resistance rate and efficacy of Cefaclor were assessed among a total of 155 patients with chronic lung diseases during the period from July 198S to June 1989. The following results were obtained: 1) The prevalence of H. influenzae in chronic airway diseases was 16.1% when routine media were used. With selective media, the positive rate was significantly highter (66.5%). 2) Among the 101 strains, 2% were serotype b and 90.1% were non-typable. 3) In the total 98% H. influenzae isolates studied, 18.4%, were resistant to ampicillin and none to Cefaclor and tetracycline, 4) The overall bacterialogical response of H. influenzae to Cefaclor, which is one of the two most active drugs, was found to be as follows: Eliminated 60.0%, Reduced markedly 22.9%, Persistent 11.4% and lncreased 5.7%, However, the results of Persistent and Increased could be found in selective media only. This study revealed the relatively high prevalence of H. influenzae in patients with Chronic airway diseases. The prevalence of H. influenzae was significantly higher when selective media was used for culture.
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