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신현종 ( Hyun Jong Shin ),김현수 ( Hyun Soo Kim ),임금남 ( Keum Nam Lim ),노유석 ( U Seok Noh ),최정혜 ( Jung Hye Choi ),김인순 ( In Soon Kim ),이영열 ( Young Yeul Lee ),박병배 ( Byeong Bae Park ),박동우 ( Dong Woo Park ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.4
Paraneoplastic limbic encephalitis is a rare disorder that is characterized by personality changes, irritability, depression, seizures, memory loss and dementia, and is commonly associated with small cell lung cancer. The cause is unknown but it is believed to be an autoimmune disorder that develops secondary to a carcinomatous process. We report a patient with the clinical feature consistent with limbic encephalitis. A 64-year-old women developed disorientation, memory loss and general weakness. She was diagnosed with NSCLC (adenocarcinoma) with a brain metastasis 1 year earlier and was treated with radiation and chemotherapy. Although the lung mass and brain metastatic lesions had improved, the brain T2-weighted MRI showed high signal intensity in the right temporal region. This lesion consisted of with limbic encephalitis and was negative to the other viral and immune markers. The patient`s symptoms did not improve after steroid treatment. Our case demonstrated that a NSCLC (adenocarcinoma) also can be associated with paraneoplastic limbic encephalitis. (Tuberc Respir Dis 2007; 63: 382-386)