http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
33권6호 영문부록 : 백서의 포르말린 검사에서 척수 NMDAR1 수용체에 대한 Antisense Oligodeoxynucleotide 의 Phase II 반응 억제 효과
이일옥(Il Ok Lee),(Gregory Crosby) 대한마취과학회 1997 영문부록 Vol.- No.-
서 론: 유해 자극에 의한 중추성 감작(central sensitization)은 후속적이고 지연적인 통증을 유발한다. N-methyl-D-aspartate (NMDA) 수용체가 이 중추성 감작에 중요한 역할을 하는 흥분성 아미노산 수용체이다. 합성 올리고데옥시누클레오티드(synthetic oligodeoxynucleotide, 이하 oligodeoxynucleotide라 표기)를 투여하면 표적 단백질의 합성을 억제한다. 따라서 이 실험은 백서에서 antisense oligodeoxynucleotide를 투여할 경우 표적 단백질인 NMDAR1 수용체의 합성이 억제됨으로써 유해 자극에 의한 중추성 감작을 저하시킬 수 있는가 알아보기 위한 실험이다. 방 법: 백서에 각각 요추 지주막하강에 PE10 카테테르를 거치한 후 생리식염수 (n=6, 대조군), 18-mer NMDAR1 antisense(n=6), sense(n=6) oligodeoxynucleotide를 5 nmol(총 20 ml)씩 48시간 간격으로 세 차례 지주막하강으로 투여하였다. 마지막 투여 다음날, 5% 포르말린 100 l를 27G 주사 바늘로 왼쪽 뒤 발바닥 피하에 주사한 후, 주춤거림(flinching)의 행동 반응을 5분 간격으로 60분간 관찰하였다. 포르말린 주사 후 5분 동안을 반응 제 1기, 주사후 20분 부터 60분 까지를 반응 제 2기라 하였다. 결 과: 생리식염수를 투여한 대조군에 비하여 18-mer NMDAR1 antisense oligodeoxynucleotide를 투여한 군은 제 2기의 주춤거림 반응을 통계적으로 유의하게 억제시켰다(p<0.05). 결 론: 백서에서 18-mer NMDAR1 antisense oligodeoxynucleotide의 지주막하강내 투여는 포르말린에 의한 중추감작에 의한 행동 반응을 효과적으로 억제할 수 있다. (Korean J Anesthesiol 1997; 33: S37∼S43)
실험연구 : 흰쥐의 포르말린주사모델에서 척수강 내 COX-아형 억제제가 통증반응과 중추신경계의 c-Fos 발현에 미치는 영향
서영선 ( Young Sun Seo ),이일옥 ( Il Ok Lee ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.1
Background: Prostaglandins (PGs) play important roles in the transmission of nociceptive information in the spinal cord. PGs are produced by cyclooxygenase (COX). Two forms of COX have been identified: COX-1 and COX-2. c-Fos is a marker of neuronal activity related to the stimulation of primary sensory neuron. We investigated the effect of intrathecal non-selective COX inhibitor, selective COX-1 or COX-2 inhibitors on the inflammatory pain and c-Fos expression in the brain. Methods: A PE (polyethylene) intrathecal catheter was installed in male Sprague-Dawley rats (250-300 g). Control, nonselective COX inhibitor, COX-1 inhibitor, and COX-2 inhibitor groups (n = 8, each) received intrathecal dimethylsulfoxide (DMSO) solution, ketorolac 50μg, SC-560 50μg, or celecoxib 50μg respectively 7 min before formalin injection. For formalin test, rats received 50μl of 5% formalin in the right hindpaw subcutaneously. Pain-related behavior was quantified by counting the incidence of flinching for 60 minutes. c-Fos expression in the thalamus, hypothalamus, and amygdala was examined by immunohistochemistry. Results: Nonselective COX inhibitor and COX-2 inhibitor groups showed less frequent phase 2 flinching than the control (P < 0.05). But there was no significant differences in the expression of FLI in the thalamus, hypothalamus, and amygdala between control and experimental groups. And the expression of FLI was not correlated with flinching behavior. Conclusions: These result represented that COX-2 would play important roles in the transmission of pain induced by formalin test and that FLI in thalamus, hypothalamus, and amygdala could not be a good parameter for evaluating central sensitization. (Korean J Anesthesiol 2007; 52: 81~90)
뇌성마비 환자에서 마취 유도 시 BIS와 Entropy 값의 비교
김남엽 ( Nam Yeop Kim ),이일옥 ( Il Ok Lee ),임병건 ( Byung Gun Lim ),김희주 ( Hee Zoo Kim ),공명훈 ( Myoung Hoon Kong ),이미경 ( Mi Kyoung Lee ),임상호 ( Sang Ho Lim ),김난숙 ( Nan Suk Kim ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.4
Background: Demand of anesthesia for patients with cerebral palsy is more increasing. But there is still lacking in clinical research regarding how BIS and entropy reflect well on sedative and hypnotic state in patients with cerebral palsy. Methods: Fifteen patients with cerebral palsy (Group CP) and fifteen patients without cerebral palsy (Group NL) scheduled for elective orthopedic surgery were included in the study. Induction of anesthesia was done by having the patient inhale 1 vol% sevoflurane and 100% oxygen using a total fresh gas flow of 8 L/min. Simultaneously BIS, state entropy (SE), response entropy (RE), end-tidal sevoflurane concentration were recorded every 15 seconds till there was no self respiration. When end-tidal sevoflurane concentration had not risen any more for 30 seconds, we increased inhaled sevoflurane concentration in 1 vol% increments. End point of recording was when self respiration was lost or the time sevoflurane concentration reached 8 vol%. Results: No significant differences in RE, SE, BIS at baseline and end point were found between the two groups. No significant difference in the time reach end point was found between the two groups. BIS, SE and RE correlated with end-tidal sevoflurane concentration in the two groups. Conclusions: The authors found no significant difference in the entropy values between patients with CP and normal patients. Also, the entropy values could be interpreted like BIS in patients with CP. And BIS showed a stronger correlation with end tidal sevoflurane concentrations than entropy. (Korean J Anesthesiol 2009;57:422~7)
척추측만증 교정수술의 수술 중 및 후 호흡기 및 순환기계 합병증에 대한 폐기능 검사의 임상적 예측성 평가: 후향적 연구
강길원 ( Gi Run Kang ),이일옥 ( Il Ok Lee ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.5
Background: This study was conducted to confirm the predictive power of preoperative pulmonary functions tests (PFTs) for intra-and post-operative cardiopulmonary complications during corrective surgery for scoliosis. Methods: A retrospective review of hospital charts of patients who underwent surgical correction for scoliosis and/or kyphosis at our medical center between September 2002 and September 2008 was performed. Results: A total of 141 patients were enrolled in this study. The overall intra- and post-operative cardiopulmonary complication rate was 33.3% (47/141). There were 32 and 19 complications related to pulmonary issues (22.7%) and cardiovascular complications (13.5%), respectively. The complication rate of neuromuscular scoliosis (NMS) was 47.3% (35/74), while that of non-neuromuscular scoliosis (NNMS) was 17.9% (12/67). The cardiopulmonary complication rates of groups with FEV1 volumes below 1 L, 1-1.5 L, 1.5-2 L and over 2 L were 66.7% (18/27), 43.3% (13/30), 20.0% (7/35) and 18.4% (9/49), respectively. The group with FEV1 volumes below 1 L showed a significantly increased risk when compared to the group with FEV1 volumes over 2 L (P<0.05, Odds ratio=5.15, multivariate logistic regression test). The cardiopulmonary complication rates of groups with FVC volumes below 1 L, 1-1.5 L, 1.5-2 L and over 2 L were 70.8% (17/24), 37.5% (9/24), 33.3% (11/33) and 16.7% (10/60), respectively. Additionally, the group with FVC volumes below 1 L showed significantly increased risk when compared to a group with FVC volumes greater than 2 L (P<0.001, Odds ratio=8.0, multivariate logistic regression). Conclusions: The correction for NMS carries a higher complication rate than NNMS. Intra- and post-operative cardiopulmonary complication rates of a group with FEV1 or FVC volumes below 1 L were higher than the rates of groups with FEV1 and FVC volumes greater than 2 L. (Korean J Anesthesiol 2009;57:590∼6)